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Mireille Johanna Serlie

Mireille Johanna Serlie (1970) is a Dutch physician-scientist, practicing internist-endocrinologist and teacher. She is Professor of Medicine at the University of Amsterdam and Yale University. Her work as a prinicipal investigator and active physician has led to clinically-informed basic science studies that have shed light on human physiology and disease. Her laboratory has consistently produced papers that impact our views on insulin resistance, diet- and obesity-induced changes in human metabolism and alterations in the dopamine and serotonin systems in the context of obesity.

Personal

Mireille Serlie was born in The Netherlands on July 25, 1970. She graduated with a MD from the University of Amsterdam and completed a residency in Internal Medicine and a fellowship in Endocrinology, Metabolism and Diabetes at the Amsterdam Medical Center. Since completing her formal training, she has remained working at the Amsterdam University Medical Center for fourteen years. During this time, she rapidly climbed the ranks from (Junior) Instructor to Full Professor of Internal Medicine.

Clinical expertise

As a practicing internist, Mireille Serlie is considered a worldwide expert in the management of patients with intestinal failure and chronic treatment with parenteral nutrition (PN). PN is the administration of nutritional products via intravenous infusion, thereby bypassing the usual route of eating and gastrointestinal digestion. Patients who cannot be sufficiently fed orally or enterally rely on total or partial PN for the prevention of malnutrition and nutritional deficiencies. The therapy includes a nutritional mix of carbohydrates, amino acids, lipids, vitamins and minerals, and is administered intravenously, usually through a central venous catheter. It is a life-saving therapy, but associated with significant complications. Therefore, patients receiving (chronic) PN are carefully monitored by Professor Serlie and her team. In addition to intestinal failure, Professor Serlie is an advocate of improving clinical nutrition and involved in national policy making regarding the optimisation of inpatient and outpatient nutrition. She is the chair of the Netherlands Society for Parenteral and Enteral Nutrition (NESPEN), a permanent member of the Scientific Committee of the European Society for Parenteral and Enteral Nutrition (ESPEN) and the chair of the Nederlands Voedingsteam Overleg (NVO).

Research

Mireille Serlie is interested in the development, prevention, management and cardiometabolic complications of obesity. Her Lab performs translational science within the fields of obesity, metabolism and neuroscience. This research spans across preclinical/animal studies, molecular biology, observational studies/epidemiology and clinical/intervention trials. In her capacity as Principal Investigator, she has co-authored more than 150 research papers in international, peer-reviewed journals.

Obesity and insulin resistance

Mireille Serlie is known for her groundbreaking contributions to our understanding of the relationship between obesity and its cardiometabolic complications, including insulin resistance and type 2 diabetes. Insulin resistance occurs when cells in the liver, muscle, adipose tissue and other tissues develop reduced responsiveness to insulin. This condition is the major risk factor for the development of type 2 diabetes and is often referred to as prediabetes. In order to study insulin resistance in humans in vivo, Mireille Serlie has successfully combined state-of-the-art metabolic flux measurements using stable isotope-labeled tracers with molecular biochemistry measurements in tissue biopsies. Using such approaches, Mireille Serlie aims to understand how the human body adapts (or disrupts) in the presence of nutritional excess or deficiency. In this regard, she has made significant discoveries on the metabolic effects of (prolonged) fasting; the detrimental effects of a hypercaloric snacking diet; the beneficial effects of intermittent fasting and meal timing; and the effects of circulating lipids, ectopic lipid accumulation, corticosteroids, fish oil, antibiotics and other microbiological interventions on insulin sensitivity. In addition, she has discovered the underlying mechanism of lipid-mediated hepatic insulin resistance in humans; the mechanisms by which increased fructose consumption contributes to lipid accumulation and insulin resistance; and the human relevance of systemic/low-grade inflammation in the context of obesity and insulin resistance. She has a special interest in sex differences in metabolism, hoping to improve representation of women in scientific studies and the outcomes of women with metabolic diseases.

Altered brain dopaminergic and serotonergic systems in obesity

Most recently, Mireille Serlie has been investigating the role the brain plays in the development and maintenance of insulin resistance and obesity. She uses neuroimaging techniques such as SPECT and functional MRI and she works closely with basic scientists and imaging experts in the Netherlands and the United States. Her Lab has performed several studies in humans showing that dopaminergic and serotonergic pathways in the brain are altered in the obese and hypercaloric state, and partially reversible after weight loss. Her studies also demonstrated that snacking changes a specific area in the brain that is involved in appetite regulation. Another observation was that the brains of overweight men respond differently to a low-calorie diet when most of the calories are eaten in the morning.

Awards and honorary titles

Mireille Serlie has received several prestigious awards:

• 2002 Fellowship award from the European Society of Parenteral and Enteral Nutrition
• 2006 Best research abstract (Dutch Society of Internal Medicine)
• 2007 Nominated Dr F. Gerritzen award (for excellent research in the field of diabetes mellitus)
• 2012 Outstanding abstract ESPEN 2012
• 2016 Academic Medical Center best clinical practice award