User:Mauzel/sandbox
S-phase kinase-associated protein 2 B is an F-box protein in the Skp, Cullin, F-box containing complex. SKP2B binds with other proteins in the cell, allowing the rest of the SCF-complex to ubiquitin the target. It is a splice variant of SKP2.
Function
[edit]Oncogene
[edit]Although a SKP2-specific and a SKP2B-specific antibody have since been developed, previous antibodies bound to all isoforms of SKP2. Therefore, previous studies noted elevated SKP2 levels, but did not differentiate between SKP2A and SKP2B.
Interactions
[edit]This is an example:
SKP2 has been shown to interact with:
References
[edit]- ^ a b Rosner M, Hengstschläger M (November 2004). "Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2". J. Biol. Chem. 279 (47): 48707–15. doi:10.1074/jbc.M405528200. PMID 15355997.
{{cite journal}}: CS1 maint: date and year (link) - ^ a b Marti A, Wirbelauer C, Scheffner M, Krek W (May 1999). "Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation". Nat. Cell Biol. 1 (1): 14–9. doi:10.1038/8984. PMID 10559858.
{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link) - ^ Yam CH, Ng RW, Siu WY, Lau AW, Poon RY (January 1999). "Regulation of Cyclin A-Cdk2 by SCF Component Skp1 and F-Box Protein Skp2". Mol. Cell. Biol. 19 (1): 635–45. doi:10.1128/MCB.19.1.635. PMC 83921. PMID 9858587.
{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link)