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Pharmaceuticals[edit]
[edit]Chelate complexes of gadolinium are often used as contrast agents in MRI scans, though iron particle and manganese chelate complexes have also been explored.[1][2] Bifunctional chelate complexes of zirconium, gallium, fluorine, copper, yttrium, bromine, or iodine are often used for conjugation to monoclonal antibodies for use in antibody-based PET imaging.[3] These chelate complexes often employ the usage of hexadentate ligands such as desferrioxamine B (DFO), and octadentate ligands such as DTPA and 3,4,3-(LI-1,2-HOPO).[2][4] Auranofin, a chelate complex of gold, is used in the treatment of rheumatoid arthritis, and penicillamine, a chelate complex of copper, is used in the treatment of Wilson's disease, cystinuria, as well as refractory rheumatoid arthritis.[5][6]
- ^ Pan, Dipanjan; Schmieder, Anne H.; Wickline, Samuel A.; Lanza, Gregory M. (2011-11-04). "Manganese-based MRI contrast agents: past, present and future". Tetrahedron. 67 (44): 8431–8444. doi:10.1016/j.tet.2011.07.076. ISSN 0040-4020. PMC 3203535. PMID 22043109.
{{cite journal}}: CS1 maint: PMC format (link) - ^ a b Caravan, P.; Ellison, J. J.; McMurry, T. J.; Lauffer, R. B. (1999-09-08). "Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications". Chemical Reviews. 99 (9): 2293–2352. ISSN 1520-6890. PMID 11749483.
- ^ Vosjan, Maria J. W. D.; Perk, Lars R.; Visser, Gerard W. M.; Budde, Marianne; Jurek, Paul; Kiefer, Garry E.; van Dongen, Guus A. M. S. (April 2010). "Conjugation and radiolabeling of monoclonal antibodies with zirconium-89 for PET imaging using the bifunctional chelate p-isothiocyanatobenzyl-desferrioxamine". Nature Protocols. 5 (4): 739–743. doi:10.1038/nprot.2010.13. ISSN 1750-2799. PMID 20360768.
- ^ Deri, Melissa A.; Ponnala, Shashikanth; Kozlowski, Paul; Burton-Pye, Benjamin P.; Cicek, Huseyin T.; Hu, Chunhua; Lewis, Jason S.; Francesconi, Lynn C. (2015-12-16). "p-SCN-Bn-HOPO: A Superior Bifunctional Chelator for (89)Zr ImmunoPET". Bioconjugate Chemistry. 26 (12): 2579–2591. doi:10.1021/acs.bioconjchem.5b00572. ISSN 1520-4812. PMC 4962612. PMID 26550847.
{{cite journal}}: CS1 maint: PMC format (link) - ^ Kean, W. F.; Hart, L.; Buchanan, W. W. (May 1997). "Auranofin". British Journal of Rheumatology. 36 (5): 560–572. ISSN 0263-7103. PMID 9189058.
- ^ Wax, Paul M. (December 2013). "Current use of chelation in American health care". Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology. 9 (4): 303–307. doi:10.1007/s13181-013-0347-2. ISSN 1937-6995. PMC 3846961. PMID 24113860.
{{cite journal}}: CS1 maint: PMC format (link)