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Pseudo-Cushing's syndrome, also called non-neoplastic physiologic hypercortisolism, it is a medical condition in which patients display similar symptom, abnormal hormone level, and endocrinological activities to Cushing’s syndrome that are either temporary or consistent.^[1]^[2] However, pseudo-Cushing's syndrome is not caused by a problem with the hypothalamic-pituitary-adrenal axis as Cushing's is; it is mainly an idiopathic condition, however a cushingoid appearance is sometimes linked to excessive alcohol consumption.^[3] Elevated levels of total cortisol can also be due to estrogen found in oral contraceptive pills that contain a mixture of estrogen and progesterone. Estrogen can cause an increase of cortisol-binding globulin and thereby cause the total cortisol level to be elevated.^[4]

Reference

^ Findling, James W; Raff, Hershel (2017-05). "DIAGNOSIS OF ENDOCRINE DISEASE: Differentiation of pathologic/neoplastic hypercortisolism (Cushing's syndrome) from physiologic/non-neoplastic hypercortisolism (formerly known as pseudo-Cushing's syndrome)". European Journal of Endocrinology. 176 (5): R205 – R216. doi:10.1530/EJE-16-0946. ISSN 0804-4643. {{cite journal}}: Check date values in: |date= (help)
^ Scaroni, Carla; Albiger, Nora M.; Palmieri, Serena; Iacuaniello, Davide; Graziadio, Chiara; Damiani, Luca; Zilio, Marialuisa; Stigliano, Antonio; Colao, Annamaria; Pivonello, Rosario (2020-01-01). "Approach to patients with pseudo-Cushing's states". Endocrine Connections. 9 (1): R1 – R13. doi:10.1530/EC-19-0435. ISSN 2049-3614. PMC 6993268. PMID 31846432.{{cite journal}}: CS1 maint: PMC format (link)
^ Parveen June Kumar; Michael L. Clark (2005). Kumar and Clark clinical medicine. Elsevier Saunders. pp. 974–975. ISBN 978-0-7020-2763-5.
^ C. W. Burke (1969). "The effect of oral contraceptives on cortisol metabolism". Journal of Clinical Pathology. 3: 11–18. doi:10.1136/jcp.s1-3.1.11. PMC 1436049.

[1] Findling, James W; Raff, Hershel (2017-05). "DIAGNOSIS OF ENDOCRINE DISEASE: Differentiation of pathologic/neoplastic hypercortisolism (Cushing's syndrome) from physiologic/non-neoplastic hypercortisolism (formerly known as pseudo-Cushing's syndrome)". European Journal of Endocrinology. 176 (5): R205 – R216. doi:10.1530/EJE-16-0946. ISSN 0804-4643. {{cite journal}}: Check date values in: |date= (help)

[2] Scaroni, Carla; Albiger, Nora M.; Palmieri, Serena; Iacuaniello, Davide; Graziadio, Chiara; Damiani, Luca; Zilio, Marialuisa; Stigliano, Antonio; Colao, Annamaria; Pivonello, Rosario (2020-01-01). "Approach to patients with pseudo-Cushing's states". Endocrine Connections. 9 (1): R1 – R13. doi:10.1530/EC-19-0435. ISSN 2049-3614. PMC 6993268. PMID 31846432.{{cite journal}}: CS1 maint: PMC format (link)

[KumarClark2005-3] Parveen June Kumar; Michael L. Clark (2005). Kumar and Clark clinical medicine. Elsevier Saunders. pp. 974–975. ISBN 978-0-7020-2763-5.

[4] C. W. Burke (1969). "The effect of oral contraceptives on cortisol metabolism". Journal of Clinical Pathology. 3: 11–18. doi:10.1136/jcp.s1-3.1.11. PMC 1436049.

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