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Role in learning and memory

A single mossy fiber projection may make as many as 37 contacts with a single pyramidal cell, but innervates only about a dozen different pyramidal cells. In contrast, a single CA3 pyramidal cell receives input from about 50 different granule cells. It has been shown in rodents that the size of the mossy fiber projections can show large interindividual variations, which are to a large part heritable.^[1] In addition, these variations show strong correlations with different types of behavior, mainly, but not exclusively, spatial learning.^[2]

https://www.ncbi.nlm.nih.gov/pubmed/29429933

https://www.ncbi.nlm.nih.gov/pubmed/29529016

https://www.ncbi.nlm.nih.gov/pubmed/29421611

Copied from Mossy fiber (hippocampus) to add new material

References

^ Crusio, WE; Genthner-Grimm, G.; Schwegler, H. (2007). "A quantitative-genetic analysis of hippocampal variation in the mouse". J. Neurogenet. 21 (4): 197–208. doi:10.1080/01677060701715827. PMID 18161583. Retrieved 2009-01-17.
^ Crusio, WE; Schwegler, H. (April 2005). "Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice". Behav Brain Funct. 1 (1): 3. doi:10.1186/1744-9081-1-3. PMC 1143776. PMID 15916698. Retrieved 2009-01-17.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid18161583-1] Crusio, WE; Genthner-Grimm, G.; Schwegler, H. (2007). "A quantitative-genetic analysis of hippocampal variation in the mouse". J. Neurogenet. 21 (4): 197–208. doi:10.1080/01677060701715827. PMID 18161583. Retrieved 2009-01-17.

[pmid15916698-2] Crusio, WE; Schwegler, H. (April 2005). "Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice". Behav Brain Funct. 1 (1): 3. doi:10.1186/1744-9081-1-3. PMC 1143776. PMID 15916698. Retrieved 2009-01-17.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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