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Categorized List of Autoimmune Diseases

[edit]

This list of autoimmune diseases is categorized by organ and tissue type to help locate diseases that may be similar.

Heart
Kidney
Liver
Lung
Skin
Endocrine
Adrenal Gland
Multi-glandular
Pancreas
Thyroid Gland
Exocrine
Reproductive Organs
Salivary Glands
Blood
Connective Tissue, Systemic, and multi-organ
Muscle
Nervous System
Eyes
Ears
Vascular system

Hypersensitivity Classification

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It is possible to classify autoimmune diseases by corresponding type of hypersensitivity: type I (i.e. urticaria induced by autologous serum), type II, type III, or type IV. [1]


Qualifiers

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The following qualifiers provide an indication of how the entry has changed from the prior version of the list, whether it is extremely rare, etc.

Other Qualifiers
A "Accepted" in prior version of this table
C A comorbidity common among people with autoimmune disease, but with no evidence of being itself caused by autoimmunity
F Disease is only caused by autoimmunity in only a fraction of those who suffer from it
I Described as an autoinflammatory disease
L Evidence to indicate autoimmunity is extremely limited or circumstantial
M Disease appears under Autoimmune Diseases in MeSH
N Not listed in prior version of this table
R Disease appeared in prior version but has been renamed. In renaming, precedence has been given to scientific names over those based on discoverers.
S "Suspected" in the prior version of this table
T Disease has a known trigger, such as viral infection, vaccination, or injury
X An extremely rare disease, which would suggest limited opportunity to study it and conclusively determine whether it is caused by autoimmunity
Y Listed in the prior version of this table with "Accepted/Suspected" left blank

Autoimmune Diseases

[edit]
This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources.
Organ/Tissue Type

Disease Name

Level of Acceptance for Autoimmunity Hypersensitivity

(I,II,III,IV)

ICD-9

Codes

Notes/Autoantibodies/Synonyms/Rare Variants
Major Organs <Top>
Heart <Top>
Myocarditis[2][3] Moderate, F, R, A 391.2422429.0 Synonyms: Autoimmune myocarditis, Autoimmune cardiomyopathy, Coxsackie myocarditis
Postmyocardial infarction syndrome[4] Limited, R, Y 411.0 Autoantibodies: myocardial neo-antigens formed as a result of the MI. Synonyms: Dressler's syndrome
Postpericardiotomy syndrome Limited, N 429.4
Subacute bacterial endocarditis[5] Limited, Y III 421.0 Autoantibodies: essential mixed cryoglobulinemia. Synonyms: SBE
Kidney <Top>
Anti-Glomerular Basement Membrane nephritis[6] Moderate, R, M, A II 446.21 Autoantibodies: Anti-Basement Membrane Collagen Type IV Protein. Synonyms: Goodpastures Syndrome, Glomerulonephritis Type 1
Interstitial cystitis[7] Limited, S 595.1 Mast cells.
Lupus nephritis Comorbidity, N 583.81 A comorbidity of Systemic Lupus Erythematosis.
Liver <Top>
Autoimmune hepatitis[8][9][10] Moderate, A cell-mediated 571.42 Autoantibodies: ANA and SMA, LKM-1, LKM-2 or LKM-3; antibodies against soluble liver antigen (anti-SLA, anti-LP) no autoantibodies detected (~20%)[citation needed]. Synonyms: Lupoid hepatitis
Primary biliary cirrhosis[11] [12] [13][14] Moderate, A 571.6 Autoantibodies: Anti-p62, Anti-sp100, Anti-Mitochondrial(M2)Anti-Ro aka SSA. Also, they are often present in Sjogren's syndrome..
Primary sclerosing cholangitis Limited, Y 576.1 Possible overlap with primary biliary cirrhosis. Autoantibodies: HLA-DR52a.
Lung <Top>
Antisynthetase syndrome Limited, Y 279.49
Skin <Top>
Alopecia Areata[15][16] Moderate, A 704.01 Autoantibodies: T-cells. Synonyms: Alopecia areata - Patchy, Totalis, Universalis
Autoimmune Angioedema[17][18] Limited, F, N 277.6 995.1
Autoimmune progesterone dermatitis Limited, X, A 279.49
Autoimmune urticaria[19][20] Comorbidity, A 708
Bullous pemphigoid[21] Moderate, Y 694.5 Autoantibodies: IgG autoantibodies targeting the type XVII collagen component of hemidesmosomes.
Cicatricial pemphigoid Limited, R, X, Y 694.61 precipitates C3. Autoantibodies: anti-BP-1, anti BP-2. Synonyms: Benign Mucosal Pemphigoid, Ocular cicatricial pemphigoid
Dermatitis herpetiformis[22] Moderate, C, Y 694.0 Autoantibodies: IgA Eosinophilia; anti-epidermal transglutaminase antibodies.
Discoid lupus erythematosus[23] Limited, Y III 695.4 IL-2 and IFN-gamma.
Epidermolysis bullosa acquisita Moderate, Y 694.8 COL7A1.
Erythema nodosum Limited, F, Y 695.2
Gestational pemphigoid Limited, R, Y 646.8 Autoantibodies: IgG and C3 misdirected antibodies intended to protect the placenta.
Hidradenitis suppurativa[24] Limited, C, S 705.83
Lichen planus Limited, Y 697.0
Lichen sclerosus Limited, C, Y 701.0
Linear IgA disease[25] Moderate , Y 646.8 Synonyms: LAD
Morphea[26] Limited, C, S 701.0
Pemphigus vulgaris[22][6] Moderate, M, A II 694.4 Autoantibodies: Anti-Desmoglein 3 eosinophilia.
Pityriasis lichenoides et varioliformis acuta Limited, C 696.2
Mucha-Habermann disease Limited, C, Y 696.2 T-cells. Synonyms: Pityriasis lichenoides, varioliformis acuta
Psoriasis[27] Moderate, A IV? 696 CD-8 T-cells, HLA-Cw6, IL-12b, IL-23b, TNFalpha, NF-κB.
Systemic scleroderma[28][26] Limited, R, S 710.1 COL1A2 and TGF-β1. Autoantibodies: anti-nuclear antibodies, anti-centromere and anti-scl70/anti-topoisomerase antibodies. Synonyms: Diffuse cutaneous systemic sclerosis, Systemic sclerosis, Scleroderma
Vitiligo[29][30] Limited, C, S 709.01 NALP-1 RERE, PTPN22, LPP, IL2RA, GZMB, UBASH3A and C1QTNF6.
Glands <Top>
Endocrine <Top>
Adrenal Gland <Top>
Addison's disease[6] Moderate, F, Y 255 Autoantibodies: 21 hydroxylase.
Multi-glandular <Top>
Autoimmune polyendocrine syndrome Moderate, A Unknown or multiple 258.1 Synonyms: Whitaker's Syndrome, APECED, Addisons Disease, Polyglandular Autoimmune Syndrome 1, PGAS-1, APS Type 1
Autoimmune polyendocrine syndrome type 2[31] Moderate, A 258.1 DQ2, DQ8 and DRB1*0404. Autoantibodies: anti-21 hydroxylase, anti-17 hydroxylase. Synonyms: Schmidt syndrome, Polyglandular Autoimmune Syndrome 2, PGAS-2, APS Type 2
Autoimmune polyendocrine syndrome type 3 Moderate, A 258.1 Synonyms: Polyglandular Autoimmune Syndrome 3, PGAS-3, APS Type 3
Pancreas <Top>
Autoimmune pancreatitis Moderate, A 577.1 Autoantibodies: ANA; anti-lactoferrin antibodiesanti-carbonic anhydrase antibodies; rheumatoid factor.
Diabetes mellitus type 1[6] Moderate, A IV 250.01 HLA-DR3, HLA-DR4. Autoantibodies: Glutamic acid decarboxylase antibodies (GADA), islet cell antibodies (ICA), and insulinoma-associated autoantibodies (IA-2), anti-insulin antibodies.
Thyroid Gland <Top>
Autoimmune thyroiditis Strong, A IV 245.8 HLADR5, CTLA-4. Autoantibodies: antibodies against thyroid peroxidase and/or thyroglobulin. Synonyms: chronic lymphocytic thyroiditis, Hashimoto's thyroiditis
Ord's thyroiditis Moderate, Y 245.8
Graves' disease[6] Moderate, M, A II 242.0 Autoantibodies: thyroid autoantibodies (TSHR-Ab) that activate the TSH-receptor (TSHR).
Exocrine <Top>
Reproductive Organs <Top>
Autoimmune oophoritis Moderate, N 614.2
Endometriosis[32] Limited, S 617.0
Autoimmune orchitis Limited, N 604.0
Salivary Glands <Top>
Sjogren's syndrome[6][12][13][14] Moderate, A 710.2 Autoantibodies: anti-Ro. Also, they are often present in Sjogren's syndrome..
Digestive System <Top>
Autoimmune enteropathy Moderate, X, Y None}}
Celiac disease[33][34][35] Moderate, A IV?? 579.0 HLA-DQ8 and DQ2.5. Autoantibodies: Anti-tissue transglutaminase antibodies anti-endomysial IgA, anti-gliadin IgA.
Crohn's disease[36] Moderate, Y IV 555 Innate immunity; Th17; Th1; ATG16L1; CARD15;XBP1;.
Microscopic colitis Limited, S 558.9
Ulcerative colitis[6] Limited, A IV 556
Tissue <Top>
Blood <Top>
Antiphospholipid syndrome[6] Moderate, M, A 289.81 HLA-DR7, HLA-B8, HLA-DR2, HLA-DR3. Autoantibodies: anti-cardiolipin;anti pyruvate dehydrogenase; β2 glycoprotein I; phosphatidylserine; anti apoH; Annexin A5.
Aplastic anemia Limited, F, Y 284
Autoimmune hemolytic anemia Moderate, M, A II 283.0 complement activation.
Autoimmune lymphoproliferative syndrome Moderate, A 279.41 TNFRSF6; defective Fas-CD95 apoptosis. Synonyms: Canale-Smith Syndrome
Autoimmune neutropenia Moderate, F, N 288.09
Autoimmune thrombocytopenic purpura[6] Moderate, M, R, A 287.31 Autoantibodies: anti gpIIb-IIIa or 1b-IX. Synonyms: Idiopathic Thrombocytopenic Purpura
Cold agglutinin disease Moderate, M, A II 283.0 idiopathic or secondary to leukemia or infection. Autoantibodies: IgM. Synonyms: Autoimmune hemolytic anemia?
Essential mixed cryoglobulinemia Limited, C, Y 273.2
Evans syndrome Moderate, Y 287.32 Synonyms: A synonym for a combination of hemolytic anemia and thrombocytopenic purpura
IgG4-related systemic disease Limited, C, N
Paroxysmal nocturnal hemoglobinuria Limited, F, S 283.2
Pernicious anemia[37] Moderate, A II 281.0 Autoantibodies: anti-parietal cell antibody.
Pure red cell aplasia Limited, Y 284.81
Thrombocytopenia[38][39] Limited, F, Y II 287.5 Multiple mechanisms. Autoantibodies: glycoproteins IIb-IIIa or Ib-IX in ITP anti-ADAMTS13 in TTP. and HUS anti-cardiolipin (anti-cardiolipin antibodies) and β2 glycoprotein I in Antiphospholipid syndrome anti-HPA-1a, anti-HPA-5b, and others in NAIT. Synonyms: Neonatal thrombocytopenia
Connective Tissue, Systemic, and multi-organ <Top>
Adiposis dolorosa[40] Limited, L, S 272.8 Lipoid tissue. Synonyms: Dercum's disease
Adult-onset Still's disease[41] Moderate, Y 714.2 macrophage migration inhibitory factor. Autoantibodies: ANA.
Ankylosing Spondylitis[42][43] Limited, S 720.0 CD8; HLA-B27.
CREST syndrome Limited, Y 710.1 Autoantibodies: Anti-centromere antibodies Anti-nuclear antibodies.
Drug-induced lupus Moderate, Y 710.0 Autoantibodies: Anti-histone antibodies.
Enthesitis-related arthritis[44][45] [46] [47] Limited, C, Y MMP3, TRLR2, TLR4, ERAP1. Autoantibodies: .. Synonyms: A subtype of Juvenile Rheumatoid Arthritis
Eosinophilic fasciitis Limited, F, A 728.89 Synonyms: Shulman's syndrome
Felty syndrome[48] Strong, M, Y 714.1
Juvenile Arthritis[41] Strong, M, R, Y 714.30 Autoantibodies: inconsistent ANA Rheumatoid factor. Synonyms: Juvenile rheumatoid arthritis, Juvenile idiopathic arthritis
Lyme disease (Chronic)[49] Limited, L, T, N 088.81
Mixed connective tissue disease[6] Moderate, M, A 710.8 HLA-DR4. Autoantibodies: anti-nuclear antibody anti-U1-RNP.
Palindromic rheumatism[50] Limited, Y 719.3 Autoantibodies: anti-cyclic citrullinated peptide antibodies (anti-CCP) and antikeratin antibodies (AKA). Synonyms: Hench-Rosenberg syndrome
Parry Romberg syndrome Limited, Y 349.89351.8 Autoantibodies: ANA.
Parsonage-Turner syndrome Limited, Y 353.5
Psoriatic arthritis[51] Moderate, C, A IV? 696.0 HLA-B27.
Reactive arthritis Limited, C, F, Y 099.3 Synonyms: Reiter's syndrome
Relapsing polychondritis[52] Strong, A 733.99 Synonyms: atrophic polychondritis, systemic chondromalacia, chronic atrophic polychondritis, Meyenburg-Altherr-Uehlinger syndrome, generalized chondromalacia, systemic chondromalacia
Retroperitoneal fibrosis Limited, Y 593.4
Rheumatic fever[53] [54] Moderate, T, A II 390 Autoantibodies: streptococcal M protein cross reacts with human myosin.
Rheumatoid arthritis[6] Strong, M, A III 714 HLA-DR4, PTPN22, depleted B cells, TNF alpha, IL-17, (also maybe IL-1, 6, and 15). Autoantibodies: Rheumatoid factor (anti-IgGFc), Anti-MCV, ACPAs(Vimentin).
Sarcoidosis[55][56] [57] Limited, S IV 135 BTNL2; HLA-B7-DR15; HLA DR3-DQ2.
Schnitzler syndrome Limited, L, X, Y 273.1 IgM?.
Systemic Lupus Erythematosus[58][12][13][14][22][6] Strong, M, A III 695.4 Autoantibodies: Anti-nuclear antibodies anti-Ro. Also, they are often present in Sjogren's syndrome. Eosinophilia. Synonyms: Lupus
Undifferentiated connective tissue disease Moderate, C, A 710.9 HLA-DR4. Autoantibodies: anti-nuclear antibody. Synonyms: Latent lupus, incomplete lupus
Muscle <Top>
Dermatomyositis[59][60] Moderate, F, X, A 710.3 B- and T-cell perivascular inflammatory infiltrate on muscle biopsy. Autoantibodies: histidine-tRNA anti-signal recognition peptide Anti-Mi-2 Anti-Jo1.. Synonyms: Juvenile dermatomyositis
Fibromyalgia Limited, C, F, N 729.1
Inclusion body myositis Limited, F, Y 359.71 Similar to polymyositis but does not respond to steroid therapy-activated T8 cells.
Myositis Limited, F, Y 729.1
Myasthenia gravis[6] Strong, M, A II 358 HA-B8 HLA-DR3 HLA-DR1. Autoantibodies: nicotinic acetylcholine receptor MuSK protein.
Neuromyotonia[61] Limited, F, S II? 333.90 Autoantibodies: Voltage-gated potassium channels. Synonyms: Isaacs' Syndrome
Paraneoplastic cerebellar degeneration[62][63][64] Limited, Y IV? II? 334.9 Autoantibodies: anti-Yo (anti-cdr-2 in purkinje fibers) anti-Hu, anti-Tr, antiglutamate receptor.
Polymyositis[59] Limited, F, A 710.4 Autoantibodies: IFN-gamma, IL-1, TNF-alpha.
Nervous System <Top>
Acute disseminated encephalomyelitis Strong, M, T, A 323.61323.81 Synonyms: ADEM, Perivenous encephalomyelitis, Acute hemorrhagic leukoencephalitis, AHL, AHLE, acute necrotizing encephalopathy (ANE), acute hemorrhagic encephalomyelitis (AHEM), acute necrotizing hemorrhagic leukoencephalitis (ANHLE), Weston-Hurst syndrome, Hurst's disease
Acute motor axonal neuropathy[65] Limited, N 356.8
Anti-N-Methyl-D-Aspartate Receptor Encephalitis[66] Moderate, N Synonyms: Anti-NMDA Encephalitis
Balo concentric sclerosis Moderate, Y 341.1 Synonyms: Balo disease, Schilders disease
Bickerstaff's encephalitis Limited, Y 323.62 similar to Guillain-Barré syndrome. Autoantibodies: Anti-GQ1b 2/3 patients.
Chronic inflammatory demyelinating polyneuropathy[67] Moderate, C, Y 357.81 similar to Guillain–Barré syndrome. Autoantibodies: anti-ganglioside antibodies. Synonyms: Relapsing polyneuropathy (CRP), chronic inflammatory demyelinating polyradiculoneuropathy, Chronic inflammatory demyelinating polyneuritis
Guillain–Barré syndrome[6] Strong, M, A IV 357.0 Autoantibodies: Anti-ganglioside, anti-GQ1b. Synonyms: Miller-Fisher syndrome, Landry's paralysis
Hashimoto's encephalopathy[6] [68] Moderate, C, X, A IV Autoantibodies: alpha-enolase. Synonyms: Steroid-responsive encephalopathy associated with autoimmune thyroiditis, SREAT, Nonvasculitic autoimmune meningoencephalitis, NAIM, Encephalopathy Associated with Autoimmune Thyroid Disease, EAATD
Idiopathic inflammatory demyelinating diseases Limited, F, Y 356.8 a variant of multiple sclerosis.
Lambert-Eaton myasthenic syndrome Strong, M, Y 358.1 HLA-DR3-B8. Autoantibodies: voltage-gated calcium channels; Q-type calcium channel, synaptogagmin, muscarinic acetylcholine receptor M1.
Multiple sclerosis[69][69] [70] Strong, M, A IV 340 Autoantibody against potassium channel. Also invoved HLA-DR2, PECAM-1, Anti-myelin basic protein. Autoantibodies: Anti-Kir4.1 (heterogeneous). Synonyms: Primary progressive multiple sclerosis, Relapsing-remitting multiple sclerosis, disseminated sclerosis, encephalomyelitis disseminata
Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus Limited, F, S II? 279.49 antibodies against streptococcal infection serve as auto-antibodies. Synonyms: PANDAS
Progressive inflammatory neuropathy Limited, X, S 356.4 similar to Guillain-Barré syndrome. Autoantibodies: Anti-ganglioside antibodies:anti-GM1, anti-GD1a, anti-GQ1b.
Restless leg syndrome Limited, C, S 333.94 May occur in Sjogren's syndrome, celiac disease, and rheumatoid arthritis or in derangements of iron metabolism.
Stiff person syndrome[71] Limited, S 333.91 GLRA1 (glycine receptor). Autoantibodies: glutamic acid decarboxylase (GAD).
Sydenham chorea Limited, T, Y 392
Transverse myelitis Limited, M, A 323.82341.2
Eyes <Top>
Autoimmune retinopathy[72] Limited, X, N
Autoimmune uveitis Moderate, F, A 364 Autoantibodies: HLAB-27?.
Cogan syndrome Limited, F, Y 370.52
Graves ophthalmopathy Moderate, M, N 242.9
Intermediate uveitis Limited, L, Y 364.3 Synonyms: Pars planitis, Peripheral Uveitis
Ligneous conjunctivitis Limited, L, N 372.39
Mooren's ulcer Limited, L, N 370.07
Neuromyelitis optica[73][74] Limited, M, Y II? 341.0 Autoantibodies: NMO-IgG aquaporin 4. Synonyms: Devic's disease
Opsoclonus myoclonus syndrome[75] Limited, X, S IV? 379.59 Lymphocyte recruitment to CSF.
Optic neuritis Limited, C, Y 377.30
Scleritis Limited, C, Y 379.0
Susac's syndrome Limited, C, Y 348.39 Synonyms: Retinocochleocerebral Vasculopathy
Sympathetic ophthalmia Limited, I, Y 360.11 Autoantibodies: ocular antigens following trauma.
Tolosa-Hunt syndrome Limited, I, X, Y 378.55
Ears <Top>
Autoimmune inner ear disease[76] Limited, A 388.8 Synonyms: AIED
Ménière's disease[77] Limited, Y III? 386.00 Autoantibodies: major peripheral myelin protein P0.
Vascular system <Top>
Anti-neutrophil cytoplasmic antibody-associated vasculitis[78] Strong, M, A 447.6 Autoantibodies: Anti-neutrophil cytoplasmic(cANCA). Synonyms: Wegener Granulomatosis, Granulomatosis with Polyangiitis
Behçet's disease Limited, I, X, A 136.1 immune-mediated systemic vasculitis; linkage to HLA-B51 (HLA-B27); very different manifestations with ulcers as common symptom; . Synonyms: Morbus Adamandiades-Behçet. Rare Variant: Hughes-Stovin syndrome
Churg-Strauss syndrome[22] Limited, I, X, Y 446.4 Autoantibodies: p-ANCA Eosinophilia.
Giant cell arteritis [6] Limited, I, R, A IV 446.5 Synonyms: Cranial arteritis, Temporal Arteritis
Henoch-Schonlein purpura Limited, L, Y 287.0 Autoantibodies: immunoglobulin A (IgA) and complement component 3 (C3). Synonyms: anaphylactoid purpura, purpura rheumatica, Schönlein–Henoch purpura
Kawasaki's disease Limited, S 446.1 ITPKC HLA-B51. Synonyms: Kawasaki syndrome, lymph node syndrome, mucocutaneous lymph node syndrome
Leukocytoclastic vasculitis Limited, L, Y 447.6
Lupus vasculitis Moderate, C, N 583.81 A comorbidity of Systemic Lupus Erythematosis.
Rheumatoid vasculitis Moderate, C, N 447.6 A symptom of Lupus.
Microscopic polyangiitis Limited, Y 446.0 Binds to neutrophils causing them to degranulate and damages endothelium. Autoantibodies: p-ANCA myeloperoxidase. Synonyms: microscopic polyarteritis,microscopic polyarteritis nodosa, MPA
Polyarteritis nodosa Limited, L, Y 446.0 Synonyms: panarteritis nodosa, periarteritis nodosa, Kussmaul disease, Kussmaul-Maier disease
Polymyalgia rheumatica Limited, L, Y 725
Urticarial vasculitis[79] Limited, X, Y II? 708.9 Clinically may resemble type I hypersensitivity. Autoantibodies: anti C1q antibodies.
Vasculitis[21] Strong, I, M, F, A III 447.6 Autoantibodies: sometimes ANCA.

Autoimmune Comorbidities

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This list includes conditions that are not diseases but signs common to autoimmune disease. Some, such as Chronic Fatigue Syndrome, are controversial[80]. These conditions are included here because they are frequently listed as autoimmune diseases but should not be included in the list above until there is more consistent evidence.

Organ/Tissue Type

Disease Name

Level of Acceptance for Autoimmunity Hypersensitivity

(I,II,III,IV)

ICD-9

Codes

Notes/Autoantibodies/Synonyms
Chronic fatigue syndrome Comorbidity, N Symptomatic of autoimmune diseases or autoimmune activity, but not a disease or a cause of disease.
Complex regional pain syndrome Comorbidity, N Symptomatic of autoimmune diseases or autoimmune activity, but not a disease or a cause of disease. Synonyms: Amplified Musculoskeletal Pain Syndrome, Reflex Neurovascular Dystrophy, Reflex sympathetic dystrophy
Eosinophilic esophagitis Comorbidity, N 530.13 Synonyms: Comorbid with celiac disease
Gastritis Comorbidity, Y Possibly symptomatic of autoimmune diseases, but not a disease or a cause of disease. Autoantibodies: serum antiparietal and anti-IF antibodies.
POEMS syndrome[81] Comorbidity, Y Possibly symptomatic of autoimmune diseases, but not a disease or a cause of disease. Autoantibodies: interleukin 1β, interleukin 6 and TNFα. vascular endothelial growth factor (VEGF), given the ..
Raynaud phenomenon Comorbidity, S Symptomatic of autoimmune diseases or autoimmune activity, but not a disease or a cause of disease.
Primary immunodeficiency[82] Comorbidity, N 279.8 The condition is inherited, but it is associated with several autoimmune diseases.
Pyoderma gangrenosum Comorbidity, Y Possibly symptomatic of autoimmune diseases, but not a disease or a cause of disease.

Not Autoimmune

[edit]

At this time, there is not sufficient evidence - direct, indirect, or circumstantial - to indicate that these diseases are caused by autoimmunity. These conditions are included here because:

  1. The disease was listed in the prior version of this table
  2. The disease is included in several widely used lists of autoimmune disease. It is included here to ensure that a person visiting this page does not conclude that the disease was not considered. Before moving a condition from here to the list of autoimmune diseases, references should be provided in the Wikipedia page for the condition that point to evidence of autoimmunity.
Organ/Tissue Type

Disease Name

Level of Acceptance for Autoimmunity Hypersensitivity

(I,II,III,IV)

ICD-9

Codes

Notes/Autoantibodies/Synonyms
Agammaglobulinemia Not Autoimmune, Y 279.00 An immune system disorder but not an autoimmune disease.. Autoantibodies: IGHM; IGLL1: CD79A; CD79B; BLNK; LRRC8A.
Amyloidosis Not Autoimmune, N 277.30 No consistent evidence of association with autoimmunity.
Amyotrophic lateral sclerosis Not Autoimmune, Y 335.20 No consistent evidence of association with autoimmunity. Autoantibodies: Amyotrophic lateral sclerosis (Also Lou Gehrig's disease; Motor Neuron Disease).
Anti-tubular basement membrane nephritis Not Autoimmune, N No consistent evidence of association with autoimmunity.
Atopic allergy Not Autoimmune, Y I 691.8 A hypersensitivity.
Atopic dermatitis Not Autoimmune, Y I 691.8 A hypersensitivity.
Autoimmune peripheral neuropathy Not Autoimmune, F, A A class of diseases, some of which may be autoimmune. See specific diseases that are listed as autoimmune..
Blau syndrome Not Autoimmune, Y Overlaps both sarcoidosis and granuloma annulare. No evidence of association with autoimmunity.
Cancer Not Autoimmune, Y No consistent evidence of association with autoimmunity.
Castleman's disease Not Autoimmune, Y An immune system disorder but not an autoimmune disease.. Autoantibodies: Over expression of IL-6.
Chagas disease[83] Not Autoimmune, S No consistent evidence of association with autoimmunity.
Chronic obstructive pulmonary disease[84][85] Not Autoimmune, S No consistent evidence of association with autoimmunity.
Chronic recurrent multifocal osteomyelitis Not Autoimmune, Y LPIN2, D18S60. Synonyms: Majeed syndrome
Complement component 2 deficiency Not Autoimmune, Y Possibly symptomatic of autoimmune diseases, but not a disease.
Congenital heart block Not Autoimmune, N May be related to autoimmune activity in the mother.
Contact dermatitis Not Autoimmune, Y IV A hypersensitivity.
Cushing's syndrome Not Autoimmune, Y No consistent evidence of association with autoimmunity.
Cutaneous leukocytoclastic angiitis Not Autoimmune, Y No consistent evidence of association with autoimmunity. Autoantibodies: neutrophils.
Dego's disease Not Autoimmune, Y No consistent evidence of association with autoimmunity.
Eczema[86][87][88] Not Autoimmune, Y No consistent evidence of association with autoimmunity. Autoantibodies: LEKTI, SPINK5, filaggrin., Brain-derived neurotrophic factor (BDNF) and Substance P..
Eosinophilic gastroenteritis Not Autoimmune, Y Possibly a hypersensitivity. Autoantibodies: IgE, IL-3, IL-5, GM-CSF, eotaxin.
Eosinophilic pneumonia Not Autoimmune, F, Y A class of diseases, some of which may be autoimmune. Specifically, Churg-Strauss syndrome, a subtype of Eosinophilic pneumonia, is autoimmune.
Erythroblastosis fetalis Not Autoimmune, Y II Mother's immune system attacks fetus. An immune system disorder but not autoimmune. Autoantibodies: ABO, Rh, Kell antibodies.
Fibrodysplasia ossificans progressiva Not Autoimmune, Y Possibly an immune system disorder but not autoimmune. Autoantibodies: ACVR1 Lymphocytes express increased BMP4.
Gastrointestinal pemphigoid Not Autoimmune, A No consistent evidence of association with autoimmunity.
Hypogammaglobulinemia Not Autoimmune, Y An immune system disorder but not autoimmune. Autoantibodies: IGHM, IGLL1, CD79A, BLNK, LRRC8A, CD79B.
Idiopathic giant-cell myocarditis[89] Not Autoimmune, N No consistent evidence of autoimmune cause though the disease has been found comorbid with other autoimmune diseases. Synonyms: Giant cell myocarditis
Idiopathic pulmonary fibrosis[90][90] Not Autoimmune, Y Autoantibodies: SFTPA1, SFTPA2, TERT, and TERC.. Synonyms: Fibrosing alveolitis
IgA nephropathy Not Autoimmune, Y III? Autoantibodies: IgA produced from marrow rather than MALT. Synonyms: IgA nephrits, Berger's disease, Synpharyngitic Glomerulonephritis. An immune system disorder but not an autoimmune disease.
Immunoregulatory lipoproteins[91] Not Autoimmune, N Not a disease.
IPEX syndrome Not Autoimmune, N A genetic mutation in FOXP3 that leads to autoimmune diseases, but no consistent evidence that it is an autoimmune disorder itself.. Synonyms: X-linked polyendocrinopathy, immunodeficiency and diarrhea-syndrome (XLAAD)
Ligneous conjunctivitis Not Autoimmune, N No consistent evidence of association with autoimmunity.
Majeed syndrome Not Autoimmune, Y No consistent evidence of association with autoimmunity. Autoantibodies: LPIN2.
Narcolepsy[92][93] [94][95] Not Autoimmune, Y II? No evidence of association with autoimmunity. Research not reproducible.. Autoantibodies: hypocretin or orexin, HLA-DQB1*0602.
Rasmussen's encephalitis Not Autoimmune, Y No consistent evidence of association with autoimmunity. Autoantibodies: anti-NR2A antibodies.
Schizophrenia[96][97][98] Not Autoimmune, S No consistent evidence of association with autoimmunity.
Serum sickness Not Autoimmune, Y III A hypersensitivity.
Spondyloarthropathy Not Autoimmune, Y No consistent evidence of association with autoimmunity. Autoantibodies: HLA-B27.
Sweet's syndrome Not Autoimmune, Y No consistent evidence of association with autoimmunity. Autoantibodies: GCSF.
Takayasu's arteritis Not Autoimmune, Y No consistent evidence of association with autoimmunity.
Undifferentiated spondyloarthropathy Not Autoimmune, Y See Enthesitis-related arthritis.
  1. ^ Parham, Peter (2005). The immune system. NY: Garland Science. p. 344. ISBN 0-8153-4093-1.
  2. ^ Root-Bernstein, Robert; Fairweather, DeLisa (December 2014). "Unresolved issues in theories of autoimmune disease using myocarditis as a framework". Journal of Theoretical Biology. 375: 101–123. doi:10.1016/j.jtbi.2014.11.022. PMC 4417457. PMID 25484004.
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