Матеріал з Вікіпедії — вільної енциклопедії.
UBB
Наявні структури
PDB Пошук ортологів: PDBe RCSB
Список кодів PDB
2KHW , 2MBB , 2MRO , 2MSG , 4UEL , 4UF6 , 4WLR , 4WUR , 4ZPZ , 5CAW , 3OJ3 , 5DK8 , 5CRA , 4ZFR , 5CVO , 3ZLZ , 4WHV , 4ZFT , 3ZNH , 5D0M , 2Y5B , 2KWV , 5D0K , 5DFL , 5CVM , 4WZP , 5EDV , 5CVN , 2KWU , 4XOF , 5BNB , 2N13 , 4ZUX , 5IFR , 5IBK , 5KGF , 5JG6 , 5K9P , 5E6J
Ідентифікатори
Символи UBB Зовнішні ІД
OMIM : 191339 MGI: 98888 HomoloGene: 75104 GeneCards: UBB
Онтологія гена Молекулярна функція
• GO:0001948, GO:0016582 protein binding • protein tag • ubiquitin protein ligase binding
Клітинна компонента
• цитоплазма • endocytic vesicle membrane • гіалоплазма • мітохондрія • neuron projection • клітинне ядро • екзосома • клітинна мембрана • нуклеоплазма • soma • endosome membrane • міжклітинний простір • мітохондріальна зовнішня мембрана • endoplasmic reticulum quality control compartment • везикула • endoplasmic reticulum membrane • host cell
Біологічний процес
• DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • negative regulation of epidermal growth factor receptor signaling pathway • interstrand cross-link repair • nucleotide-excision repair, DNA damage recognition • positive regulation of canonical Wnt signaling pathway • tumor necrosis factor-mediated signaling pathway • regulation of type I interferon production • positive regulation of protein monoubiquitination • TRIF-dependent toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • endosomal transport • global genome nucleotide-excision repair • NIK/NF-kappaB signaling • G2/M transition of mitotic cell cycle • stress-activated MAPK cascade • transforming growth factor beta receptor signaling pathway • macroautophagy • negative regulation of canonical Wnt signaling pathway • nucleotide-excision repair, DNA gap filling • error-free translesion synthesis • regulation of tumor necrosis factor-mediated signaling pathway • stimulatory C-type lectin receptor signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • JNK cascade • regulation of transcription from RNA polymerase II promoter in response to hypoxia • nucleotide-excision repair, DNA incision • I-kappaB kinase/NF-kappaB signaling • вроджений імунітет • Сигнальний шлях Notch • neuron projection morphogenesis • regulation of mRNA stability • protein polyubiquitination • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • virion assembly • positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator • positive regulation of NF-kappaB transcription factor activity • anaphase-promoting complex-dependent catabolic process • negative regulation of type I interferon production • nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of protein ubiquitination • GO:0046795 intracellular transport of virus • regulation of proteasomal protein catabolic process • GO:0019067 Життєвий цикл вірусу • MyD88-dependent toll-like receptor signaling pathway • error-prone translesion synthesis • MAPK cascade • regulation of mitochondrial membrane potential • fibroblast growth factor receptor signaling pathway • ion transmembrane transport • glycogen biosynthetic process • regulation of neuron death • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • translesion synthesis • transcription-coupled nucleotide-excision repair • mitochondrion transport along microtubule • T cell receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of signal transduction by p53 class mediator • positive regulation of epidermal growth factor receptor signaling pathway • Wnt signaling pathway • nucleotide-excision repair, DNA duplex unwinding • nucleotide-excision repair, DNA incision, 5'-to lesion • ERBB2 signaling pathway • Wnt signaling pathway, planar cell polarity pathway • nucleotide-excision repair, preincision complex assembly • proteasome-mediated ubiquitin-dependent protein catabolic process • згортання білків • negative regulation of G2/M transition of mitotic cell cycle • Убіквітин-залежний протеоліз • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • entry of bacterium into host cell • трансмембранний транспорт • regulation of necroptotic process • membrane organization • endoplasmic reticulum mannose trimming • cellular iron ion homeostasis • regulation of hematopoietic stem cell differentiation • protein targeting to peroxisome • male meiosis I • female meiosis I • male gonad development • female gonad development • cytokine-mediated signaling pathway • modification-dependent protein catabolic process • hypothalamus gonadotrophin-releasing hormone neuron development • adipose tissue development • fat pad development • interleukin-1-mediated signaling pathway • seminiferous tubule development • energy homeostasis
Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних Ортологи
Види
Людина Миша Entrez Ensembl UniProt RefSeq (мРНК)
RefSeq (білок)
Локус (UCSC)
Хр. 17: 16.38 – 16.38 Mb Хр. 11: 62.44 – 62.44 Mb PubMed search[ 1] [ 2] Вікідані
UBB (англ. Ubiquitin B ) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми.[ 3] амінокислот , а молекулярна маса — 25 762[ 4]
Послідовність амінокислот
10
20
30
40
50
MQIFVKTLTG
KTITLEVEPS
DTIENVKAKI
QDKEGIPPDQ
QRLIFAGKQL
EDGRTLSDYN
IQKESTLHLV
LRLRGGMQIF
VKTLTGKTIT
LEVEPSDTIE
NVKAKIQDKE
GIPPDQQRLI
FAGKQLEDGR
TLSDYNIQKE
STLHLVLRLR
GGMQIFVKTL
TGKTITLEVE
PSDTIENVKA
KIQDKEGIPP
DQQRLIFAGK
QLEDGRTLSD
YNIQKESTLH
LVLRLRGGC
Кодований геном білок за функцією належить до фосфопротеїнів .
Локалізований у цитоплазмі , ядрі .
Baker R.T., Board P.G. (1987). The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily . Nucleic Acids Res . 15 : 443— 463. PMID 3029682 doi :10.1093/nar/15.2.443 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res . 14 : 2121— 2127. 2004. PMID 15489334 doi :10.1101/gr.2596504 Schlesinger D.H., Goldstein G. (1975). Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man . Nature . 255 : 423— 424. PMID 1128706 doi :10.1038/255423a0 Huang F., Kirkpatrick D., Jiang X., Gygi S.P., Sorkin A. (2006). Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol. Cell . 21 : 737— 748. PMID 16543144 doi :10.1016/j.molcel.2006.02.018 Okumura F., Hatakeyama S., Matsumoto M., Kamura T., Nakayama K. (2004). Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis . J. Biol. Chem . 279 : 53533— 53543. PMID 15466860 doi :10.1074/jbc.M402916200 Komander D. (2009). The emerging complexity of protein ubiquitination. Biochem. Soc. Trans . 37 : 937— 953. PMID 19754430 doi :10.1042/BST0370937
