Talk:Curcumin

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Curcumin.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Wiki Education assignment: Endocrinology

This article was the subject of a Wiki Education Foundation-supported course assignment, between 7 January 2025 and 21 March 2025. Further details are available on the course page. Student editor(s): Ebents (article contribs). Peer reviewers: Vaishsrinivasan.

— Assignment last updated by Vaishsrinivasan (talk) 02:17, 21 March 2025 (UTC)[reply]

Contradiction

"curcumin is an unstable, reactive, non-bioavailable compound and, therefore, a highly improbable lead"

It says this right after saying

"As a component of turmeric, curcumin may interact with prescription drugs and dietary supplements. In high amounts, it may be unsafe for women during pregnancy. It may cause side effects, such as nausea, diarrhea, hives, or dizziness"

If it is non-bioavailable, it couldn't do these things. 73.10.238.72 (talk) 04:09, 11 May 2025 (UTC)[reply]

There isn't a contradiction when the fate of ingested curcumin is considered:

During digestion, curcumin would be degraded from the parent polyphenol into smaller constituents having different distribution and rates of excretion, i.e., an unstable, improbable lead compound with undefinable bioavailability. See further discussion.

The same curcumin metabolites may have a concentration-dependent interaction with drugs and supplements, as occurs with grapefruit. Zefr (talk) 06:22, 11 May 2025 (UTC)[reply]