MSPI (nerve agent)
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| Names | |
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| Other names
MSMPID
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C5H9N2O2PS | |
| Molar mass | 192.17 g·mol−1 |
| Hazards | |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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3.15 mg/kg (mice, subcutaneous) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
MSPI is an irreversible acetylcholinesterase inhibitor. MSPI reacts with the acetylcholinesterase to form an aged enzyme adduct that can't be reactivated by cholinesterase reactivators.[1]
See also
[edit]References
[edit]- ^ Chabrier, P. E.; Jacob, J. (May 1980). "In vivo and in vitro inhibition of cholinesterase by methyl-1 (S methyl phosphoryl-3) imidazolium (MSPI), a model of an "instantly" aged phosphorylated enzyme". Archives of Toxicology. 45 (1): 15–20. Bibcode:1980ArTox..45...15C. doi:10.1007/BF00303290. PMID 7396718. S2CID 24108114.
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