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Draft:Hermann Stuppner

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Hermann Stuppner
Prof. Hermann Stuppner in 2023
Born (1957-04-28) April 28, 1957 (age 68)
Deutschnofen, South Tyrol, Italy
NationalityItalian
CitizenshipItaly
Alma materUniversity of Innsbruck
Ludwig Maximilian University of Munich
University of Padua
Known forResearch on medicinal plants, Edelweiss compounds, Natural product drug discovery
Notable workExtraction of leoligin and 5-methoxyleoligin from Edelweiss
SpouseHelga Stuppner
Children2 (Stefan and Sandra)
AwardsAustrian Cross of Honour for Science and Art, First Class
Houska Prize
PSE Award
ICSB Award
WebsiteUniversity Profile

Hermann Stuppner (born 1957 in Deutschnofen, South Tyrol) is a pharmacognosy scientist and professor emeritus at the University of Innsbruck. He is renowned for his research on medicinal plants and natural product chemistry, particularly known for working on Edelweiss a famous alpine flora.[1][2] Stuppner has significantly contributed to the scientific understanding of traditional herbal remedies and their applications in modern medicine. He is the founding president of the Herbal Medicinal Products Platform Austria (HMPPA)[3] and has received several national and international awards, including Austria's prestigious Cross of Honour for Science and Art, First Class.[4]

Early Life and Education

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Hermann Stuppner attended the Franciscan Gymnasium in Bolzano and then studied pharmacy at the University of Innsbruck from 1976 to 1982.[1] After completing his master's degree, he passed the Italian state examination for the pharmacy profession at the University of Padua in 1983. Stuppner received his doctorate in pharmaceutical biology from the Ludwig Maximilian University of Munich in 1985 with a dissertation on constituents of Echinacea purpurea. He then conducted postdoctoral research, specializing in phytochemical and toxicological studies, at the University of California, Irvine (USA). In 1987, he returned to Austria and joined the Institute of Pharmacognosy at the University of Innsbruck. In 1993, he completed his habilitation at the Institute of Pharmacognosy, University of Innsbruck. In 1995, he received a call for a C-3 professorship in "Pharmazeutische Biologie" at the University of Marburg, Germany, and in 1997, he was appointed Associate Professor of Pharmacognosy at the University of Innsbruck. From 2001 to 2022, he served as Full Professor of Pharmacognosy (Pharmaceutical Biology) and Head of the Institute of Pharmacy/Pharmacognosy at the University of Innsbruck. Stuppner retired in September 2022.[4][5]

Research Contributions

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Hermann Stuppner is internationally recognized for his research in pharmacognosy and natural product chemistry. His work primarily focuses on the isolation, structural elucidation, and pharmacological evaluation of secondary metabolites derived from higher plants, especially those with anti-inflammatory, antimicrobial, antiparasitic, and antitumor properties.

A major part of his scientific legacy involves the in-depth study of Leontopodium nivale (Edelweiss), a rare alpine medicinal plant.[6] Stuppner and his team successfully identified the lignans leoligin and 5-methoxyleoligin from Edelweiss roots—compounds that have shown potential in treating cardiovascular diseases and preventing myocardial infarction.[7][8] He has also investigated various traditional medicinal plants, such as Cicerbita alpina, Sanicula europaea, Scadoxus multiflorus, and Cyperus articulatus, uncovering novel bioactive molecules with antiparasitic and cytotoxic effects in several of these species.[9] Moreover, he has significantly contributed to the development and validation of analytical methods for the quality control of herbal medicines.[10]

Stuppner served as the coordinator of the Austrian national research network (NFN) “Drugs from Nature targeting Inflammation,” a six-year interdisciplinary project funded by the Austrian Science Fund (FWF). The project brought together academic institutions and industry to identify plant-derived anti-inflammatory agents with potential therapeutic applications.[11]

In parallel, he contributed to the EU-funded project VascAgeNet – Vascular Ageing Network, a multidisciplinary initiative aimed at promoting vascular ageing as a measurable and modifiable risk factor for cardiovascular diseases.[1] Within the project, Stuppner’s expertise in natural compounds helped explore the potential of plant-derived substances in improving vascular function and healthy ageing. His involvement in this network highlights his commitment to translational research that bridges molecular pharmacognosy and preventive cardiovascular medicine.[12][13][14]

His long-standing collaboration with industry partners, such as the phytopharmaceutical company Bionorica, has led to translational research success. In 2013, one of these projects was awarded Austria’s prestigious Houska Prize for applied research.[15]

With over 550 scientific publications and more than 20,000 citations, Stuppner ranks among the most highly cited pharmacognosists in Europe.[16] He continues to contribute to international research efforts and is an influential figure in both academic and applied phytochemistry.[5]

Academic and Scientific Service

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He served for 18 years as Dean of Studies at the Faculty of Chemistry and Pharmacy at the University of Innsbruck, playing a central role in curriculum development, accreditation, and quality assurance. He was also head of the Department of Pharmacognosy and later deputy head of the Institute of Pharmacy until his retirement.[17]

Beyond university duties, he held significant leadership positions in scientific organizations. From 2006 onward, he has been the founding president of the Herbal Medicinal Products Platform Austria (HMPPA)[3][2], promoting interdisciplinary research on herbal medicines. He also served eight years as president of the Austrian Pharmaceutical Society (ÖPhG), continuing as a board member afterward.[18] Additionally, he contributed to advisory boards, review panels, and scientific societies across Europe and supported standardization efforts including contributions to the European Pharmacopoeia.[17][19][20]

Awards and Recognitions

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Hermann Stuppner was awarded the First Class Cross of Honor for Science and Art [2023].

Stuppner's contributions to science have earned him numerous accolades, including:

  • 2023 – Austrian Cross of Honour for Science and Art, First Class[4]
  • 2023 – Arno-Wolle-Preis[21]
  • 2019 – ICSB Award[22]
  • 2018 – ESCOP Recognition[23]
  • 2017 – Science Award for Outstanding Research Achievement by the Südtiroler Sparkasse Foundation[24]
  • 2017 – PSE Award of the Phytochemical Society of Europe[25]
  • 2013 – Houska-Preis - in collaboration with Bionorica[15]
  • 2005 – PHOENIX Pharmacy Science Prize[26]
  • 1992 – Science Award of the City of Innsbruck[27]
  • 1992 – Herba Research Prize[28]
  • 1992 – Fritz Pöltl Prize for Biochemistry

Selected Publications

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  • Atanasov, A. G., Waltenberger, B., Pferschy-Wenzig, E. M., Linder, T., Wawrosch, C., Uhrin, P., Temml, V., Wang, L., Schwaiger, S., Heiss, E. H., Rollinger, J. M., Schuster, D., Breuss, J. M., Bochkov, V., Mihovilovic, M. D., Kopp, B., Bauer, R., Dirsch, V. M., & Stuppner, H. (2015). Discovery and resupply of pharmacologically active plant-derived natural products: A review. In Biotechnology Advances, 33(8). https://doi.org/10.1016/j.biotechadv.2015.08.001[29]
  • Pein, H., Ville, A., Pace, S., Temml, V., Garscha, U., Raasch, M., Alsabil, K., Viault, G., Dinh, C. P., Guilet, D., Troisi, F., Neukirch, K., König, S., Bilancia, R., Waltenberger, B., Stuppner, H., Wallert, M., Lorkowski, S., Weinigel, C., …, Koeberle, A. (2018). Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. Nature Communications, 9(1). https://doi.org/10.1038/s41467-018-06158-5[30]
  • Van Anh, T. T., Mostafa, A., Rao, Z., Pace, S., Schwaiger, S., Kretzer, C., Temml, V., Giesel, C., Jordan, P. M., Bilancia, R., Weinigel, C., Rummler, S., Waltenberger, B., Hung, T., Rossi, A., Stuppner, H., Werz, O., & Koeberle, A. (2021). From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution. Acta Pharmaceutica Sinica B, 11(6). https://doi.org/10.1016/j.apsb.2021.04.011[31]
  • Speroni, E., Schwaiger, S., Egger, P., Berger, A. T., Cervellati, R., Govoni, P., Guerra, M. C., & Stuppner, H. (2006). In vivo efficacy of different extracts of Edelweiss (Leontopodium alpinum Cass.) in animal models. Journal of Ethnopharmacology, 105(3). https://doi.org/10.1016/j.jep.2005.11.019[32]
  • Alilou, M., Dibwe, D. F., Schwaiger, S., Khodami, M., Troppmair, J., Awale, S., & Stuppner, H. (2020). Antiausterity Activity of Secondary Metabolites from the Roots of Ferulahezarlalehzarica against the PANC-1 Human Pancreatic Cancer Cell Line. Journal of Natural Products, 83(4). https://doi.org/10.1021/acs.jnatprod.9b01109[33]
  • Cheilari, A., Sturm, S., Intelmann, D., Seger, C., & Stuppner, H. (2016). Head-to-Head Comparison of Ultra-High-Performance Liquid Chromatography with Diode Array Detection versus Quantitative Nuclear Magnetic Resonance for the Quantitative Analysis of the Silymarin Complex in Silybum marianum Fruit Extracts. Journal of Agricultural and Food Chemistry, 64(7). https://doi.org/10.1021/acs.jafc.5b05494[34]
  • Seger, C., Sturm, S., & Stuppner, H. (2013). Mass spectrometry and NMR spectroscopy: Modern high-end detectors for high resolution separation techniques-state of the art in natural product HPLC-MS, HPLC-NMR, and CE-MS hyphenations. In Natural Product Reports, 30(7). https://doi.org/10.1039/c3np70015a[36]
  • Siewert, B., Vrabl, P., Hammerle, F., Bingger, I., & Stuppner, H. (2019). A convenient workflow to spot photosensitizers revealed photo-activity in basidiomycetes. RSC Advances, 9(8). https://doi.org/10.1039/C8RA10181G[37]
  • Tran, T. V. A., Malainer, C., Schwaiger, S., Atanasov, A. G., Heiss, E. H., Dirsch, V. M., & Stuppner, H. (2014). NF-κB inhibitors from Eurycoma longifolia. Journal of Natural Products, 77(3). https://doi.org/10.1021/np400701k[38]

Personal Life

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Hermann Stuppner is married to Helga Stuppner, a pharmacist and academic. The couple has two children, Stefan and Sandra. Outside of his professional life, Stuppner enjoys hiking in the Tyrolean Alps and exploring nature, aligning with his passion for studying medicinal plants.

References

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  1. ^ a b c "Hermann Stuppner – Universität Innsbruck". www.uibk.ac.at (in German). Retrieved 2025-04-20.
  2. ^ a b "Arzneipflanze des Jahres: Edelweiß". science.ORF.at (in German). 2019-01-24. Retrieved 2025-04-20.
  3. ^ a b "Präsidium – HMPPA" (in German). Retrieved 2025-04-20.
  4. ^ a b c "Ehrenkreuz für Hermann Stuppner". www.uibk.ac.at (in German). 2023-11-09. Retrieved 2025-04-20.
  5. ^ a b "Hermann Stuppner – Universität Innsbruck". www.uibk.ac.at. Retrieved 2025-04-20.
  6. ^ "Die Herbal Medicinal Products Platform auf den Punkt gebracht". medonline (in Austrian German). Retrieved 2025-04-20.
  7. ^ Import, M. V. S. (2009-03-01). "Mit Edelweiß gegen Arteriosklerose". scinexx | Das Wissensmagazin (in German). Retrieved 2025-04-20.
  8. ^ Linder, Thomas; Geyrhofer, Sophie; Papaplioura, Eleni; Wang, Limei; Atanasov, Atanas G.; Stuppner, Hermann; Dirsch, Verena M.; Schnürch, Michael; Mihovilovic, Marko D. (2020-02-04). "Design and Synthesis of a Compound Library Exploiting 5-Methoxyleoligin as Potential Cholesterol Efflux Promoter". Molecules. 25 (3): 662. doi:10.3390/molecules25030662. ISSN 1420-3049. PMC 7038131. PMID 32033108.
  9. ^ "Eine Substanz aus dem Alpenedelweiß heilt Arterienverkalkung". IO (in German). 2019-08-27. Retrieved 2025-04-20.
  10. ^ "Pflanzenpower für die Frau". Ärzte Krone (in German). Retrieved 2025-04-20.
  11. ^ Waltenberger, Birgit; Atanasov, Atanas G.; Heiss, Elke H.; Bernhard, David; Rollinger, Judith M.; Breuss, Johannes M.; Schuster, Daniela; Bauer, Rudolf; Kopp, Brigitte; Franz, Chlodwig; Bochkov, Valery; Mihovilovic, Marko D.; Dirsch, Verena M.; Stuppner, Hermann (2016-03-01). "Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project". Monatshefte für Chemie - Chemical Monthly. 147 (3): 479–491. doi:10.1007/s00706-015-1653-y. ISSN 1434-4475. PMC 4785209. PMID 27069281.
  12. ^ Carpes, Raphael de Mello; Barboza, Thiago José de Souza; Rosa, Ana Cláudia de Paula; Garden, Simon John; Fleury, Beatriz Grosso; Creed, Joel Christopher; Felzenszwalb, Israel (2025-04-16). "Antibacterial and antibiofilm effects of invasive corals Tubastraea coccinea and Tubastraea tagusensis". Academia Biology. 3 (2). doi:10.20935/AcadBiol7671. ISSN 2837-4010.
  13. ^ Waltenberger, Birgit; Atanasov, Atanas G.; Heiss, Elke H.; Bernhard, David; Rollinger, Judith M.; Breuss, Johannes M.; Schuster, Daniela; Bauer, Rudolf; Kopp, Brigitte; Franz, Chlodwig; Bochkov, Valery; Mihovilovic, Marko D.; Dirsch, Verena M.; Stuppner, Hermann (2016-02-25). "Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project". Monatshefte für Chemie - Chemical Monthly. 147 (3): 479–491. doi:10.1007/s00706-015-1653-y. ISSN 0026-9247. PMC 4785209. PMID 27069281.
  14. ^ "Working Groups – VascAgeNet". Retrieved 2025-04-20.
  15. ^ a b "Größter privater Forschungspreis an Uni Innsbruck". tirol.orf.at (in German). 2013-04-26. Retrieved 2025-04-20.
  16. ^ "Hermann STUPPNER | University of Innsbruck, Innsbruck | UIBK | Department of Pharmacology | Research profile". ResearchGate. Archived from the original on 2023-06-09. Retrieved 2025-04-20.
  17. ^ a b Gau, Lydia Gallo; tirol.ORF.at (2019-09-02). "Tagung zu Arzneipflanzen in Innsbruck". tirol.ORF.at (in German). Retrieved 2025-04-20.
  18. ^ "OePHG - Home". oephg.eu. Retrieved 2025-04-20.
  19. ^ "» Nature meets Cosmetics: Forscher bereiten Phytokosmetik-Kongress in Osttirol vor osttirol-heute.at" (in German). Retrieved 2025-04-20.
  20. ^ "Eating your way to a healthy old age | Horizon Magazine". projects.research-and-innovation.ec.europa.eu. 2022-05-04. Retrieved 2025-04-20.
  21. ^ "Arno Wolle | Naturmedizin nach Arno Wolle". Verein Arno Wolle (in German). Retrieved 2025-04-20.
  22. ^ "National Center for Natural Products Research | Ole Miss". olemiss.edu. Retrieved 2025-04-20.
  23. ^ "European Scientific Cooperative on Phytotherapy". ESCOP. Retrieved 2025-04-20.
  24. ^ "Uni Innsbruck: Umwelttechniker und Pharmazeut ausgezeichnet". Südtirol News (in German). Retrieved 2025-04-20.
  25. ^ "Prizes". Phytochemical Society of Europe. Archived from the original on 2024-12-26. Retrieved 2025-04-20.
  26. ^ "Phoenix Pharmazie-Wissenschaftspreis: Nachhaltiges Engagement für die Forschung - Deutsche Apotheker Zeitung". www.deutsche-apotheker-zeitung.de (in German). Retrieved 2025-04-20.
  27. ^ "Prize for scientific research". City of Innsbruck. Retrieved 2025-04-20.
  28. ^ Österreichische Gesellschaft für Phytotherapie. "ÖGPHYT - phytotherapie.at". www.phytotherapie.at (in Austrian German). Retrieved 2025-04-20.
  29. ^ Atanasov, Atanas G.; Waltenberger, Birgit; Pferschy-Wenzig, Eva-Maria; Linder, Thomas; Wawrosch, Christoph; Uhrin, Pavel; Temml, Veronika; Wang, Limei; Schwaiger, Stefan; Heiss, Elke H.; Rollinger, Judith M.; Schuster, Daniela; Breuss, Johannes M.; Bochkov, Valery; Mihovilovic, Marko D. (December 2015). "Discovery and resupply of pharmacologically active plant-derived natural products: A review". Biotechnology Advances. 33 (8): 1582–1614. doi:10.1016/j.biotechadv.2015.08.001. PMC 4748402. PMID 26281720.
  30. ^ Pein, Helmut; Ville, Alexia; Pace, Simona; Temml, Veronika; Garscha, Ulrike; Raasch, Martin; Alsabil, Khaled; Viault, Guillaume; Dinh, Chau-Phi; Guilet, David; Troisi, Fabiana; Neukirch, Konstantin; König, Stefanie; Bilancia, Rosella; Waltenberger, Birgit (2018-09-20). "Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase". Nature Communications. 9 (1): 3834. Bibcode:2018NatCo...9.3834P. doi:10.1038/s41467-018-06158-5. ISSN 2041-1723. PMC 6148290. PMID 30237488.
  31. ^ Van Anh, Tran Thi; Mostafa, Alilou; Rao, Zhigang; Pace, Simona; Schwaiger, Stefan; Kretzer, Christian; Temml, Veronika; Giesel, Carsten; Jordan, Paul M.; Bilancia, Rossella; Weinigel, Christina; Rummler, Silke; Waltenberger, Birgit; Hung, Tran; Rossi, Antonietta (June 2021). "From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution". Acta Pharmaceutica Sinica B. 11 (6): 1629–1647. doi:10.1016/j.apsb.2021.04.011. PMC 8245855. PMID 34221873.
  32. ^ Speroni, Ester; Schwaiger, Stefan; Egger, Philipp; Berger, Anna-Theres; Cervellati, Rinaldo; Govoni, Paolo; Guerra, Maria Clelia; Stuppner, Hermann (May 2006). "In vivo efficacy of different extracts of Edelweiss (Leontopodium alpinum Cass.) in animal models". Journal of Ethnopharmacology. 105 (3): 421–426. doi:10.1016/j.jep.2005.11.019. PMID 16446066.
  33. ^ Alilou, Mostafa; Dibwe, Dya Fita; Schwaiger, Stefan; Khodami, Mojtaba; Troppmair, Jakob; Awale, Suresh; Stuppner, Hermann (2020-04-24). "Antiausterity Activity of Secondary Metabolites from the Roots of Ferula hezarlalehzarica against the PANC-1 Human Pancreatic Cancer Cell Line". Journal of Natural Products. 83 (4): 1099–1106. Bibcode:2020JNAtP..83.1099A. doi:10.1021/acs.jnatprod.9b01109. ISSN 0163-3864. PMC 7307951. PMID 32163286.
  34. ^ Cheilari, Antigoni; Sturm, Sonja; Intelmann, Daniel; Seger, Christoph; Stuppner, Hermann (2016-02-24). "Head-to-Head Comparison of Ultra-High-Performance Liquid Chromatography with Diode Array Detection versus Quantitative Nuclear Magnetic Resonance for the Quantitative Analysis of the Silymarin Complex in Silybum marianum Fruit Extracts". Journal of Agricultural and Food Chemistry. 64 (7): 1618–1626. Bibcode:2016JAFC...64.1618C. doi:10.1021/acs.jafc.5b05494. ISSN 0021-8561. PMID 26806429.
  35. ^ Gibitz Eisath, Nora; Sturm, Sonja; Stuppner, Hermann (April 2018). "Supercritical Fluid Chromatography in Natural Product Analysis – An Update". Planta Medica. 84 (6/07): 361–371. Bibcode:2018PlMed..84..361G. doi:10.1055/s-0037-1599461. ISSN 0032-0943.
  36. ^ Seger, Christoph; Sturm, Sonja; Stuppner, Hermann (2013). "Mass spectrometry and NMR spectroscopy: modern high-end detectors for high resolution separation techniques – state of the art in natural product HPLC-MS, HPLC-NMR, and CE-MS hyphenations". Natural Product Reports. 30 (7): 970–987. doi:10.1039/c3np70015a. ISSN 0265-0568. PMID 23739842.
  37. ^ Siewert, Bianka; Vrabl, Pamela; Hammerle, Fabian; Bingger, Isabella; Stuppner, Hermann (2019). "A convenient workflow to spot photosensitizers revealed photo-activity in basidiomycetes". RSC Advances. 9 (8): 4545–4552. Bibcode:2019RSCAd...9.4545S. doi:10.1039/C8RA10181G. ISSN 2046-2069. PMC 6394893. PMID 30931108.
  38. ^ Tran, Thi Van Anh; Malainer, Clemens; Schwaiger, Stefan; Atanasov, Atanas G.; Heiss, Elke H.; Dirsch, Verena M.; Stuppner, Hermann (2014-03-28). "NF-κB Inhibitors from Eurycoma longifolia". Journal of Natural Products. 77 (3): 483–488. Bibcode:2014JNAtP..77..483T. doi:10.1021/np400701k. ISSN 0163-3864. PMC 3971761. PMID 24467387.
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