CYP2D7
 | This article includes a list of references, related reading, or external links, but its sources remain unclear because it lacks inline citations. (May 2025) |
Cytochrome P450 2D7 (CYP2D7) is a member of the cytochrome P450 gene superfamily. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids, and other lipids. CYP2D7 is a segregating pseudogene,[2] meaning that some individuals may have an allele that encodes a functional enzyme, while others have an allele encoding a protein that is predicted to be non-functional. In this case, the functional allele is thought to be rare. This locus is part of a cluster of cytochrome P450 genes on chromosome 22.
Gene
[edit]The CYP2D7 gene is located on chromosome 22, near other cytochrome P450 genes, including CYP2D6 and CYP2D8P. CYP2D7 is considered a pseudogene, which means it is a non-functional gene that has lost its protein-coding ability or is not expressed. However, some individuals may possess a rare functional allele of CYP2D7, which can encode a functional enzyme.
Function and significance
[edit]CYP2D7 is closely related to CYP2D6, a gene that encodes an enzyme responsible for the metabolism of approximately 25% of clinically used drugs. The functional significance of CYP2D7 is not well understood due to its pseudogene status. However, its proximity to CYP2D6 and its potential rare functional variants make it an interesting subject for genetic and pharmacological studies.
Genetic variability
[edit]The genetic variability of CYP2D7 is not as extensively studied as that of CYP2D6. However, given its location within the cytochrome P450 gene cluster on chromosome 22, it is subject to similar genetic variations and polymorphisms. The presence of a functional allele of CYP2D7 in some individuals suggests that there may be ethnic and individual differences in its expression and function.
Clinical relevance
[edit]While CYP2D7 is primarily considered a pseudogene, the potential presence of functional alleles in some individuals could have implications for drug metabolism and response. Understanding the genetic variability of CYP2D7 may provide insights into personalized medicine and pharmacogenomics, particularly in the context of drug metabolism and potential drug-drug interactions.
References
[edit]- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Gaedigk A, Jaime LK, Bertino JS, Bérard A, Pratt VM, Bradfordand LD, et al. (2010). "Identification of Novel CYP2D7-2D6 Hybrids: Non-Functional and Functional Variants". Frontiers in Pharmacology. 1: 121. doi:10.3389/fphar.2010.00121. PMC 3153001. PMID 21833166.
Further reading
[edit]- Smith G, Stubbins MJ, Harries LW, Wolf CR (December 1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 28 (12): 1129–1165. doi:10.1080/004982598238868. PMID 9890157.
- Wolf CR, Smith G (1999). "Cytochrome P450 CYP2D6". IARC Scientific Publications (148): 209–229. PMID 10493260.
- Ding X, Kaminsky LS (2003). "Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts". Annual Review of Pharmacology and Toxicology. 43: 149–173. doi:10.1146/annurev.pharmtox.43.100901.140251. PMID 12171978.
- Daly AK, Brockmöller J, Broly F, Eichelbaum M, Evans WE, Gonzalez FJ, et al. (June 1996). "Nomenclature for human CYP2D6 alleles". Pharmacogenetics. 6 (3): 193–201. doi:10.1097/00008571-199606000-00001. PMID 8807658.
