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Chemical compound
Pharmaceutical compound
α-Hydroxyetizolam Other names α-Hydroxyetizolam Dependence Moderate Routes of Oral, sublingual, rectal Metabolism Hepatic Elimination half-life 8.2 hours[ 1] Excretion Kidney
1-[7-(2-chlorophenyl)-13-methyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-4-yl]ethanol
CAS Number PubChem CID ChemSpider UNII CompTox Dashboard (EPA ) Formula C 17 H 15 Cl N 4 O S Molar mass −1 3D model (JSmol )
CC1=NN=C2N1C3=C(C=C(S3)C(C)O)C(=NC2)C4=CC=CC=C4Cl
InChI=1S/C17H15ClN4OS/c1-9(23)14-7-12-16(11-5-3-4-6-13(11)18)19-8-15-21-20-10(2)22(15)17(12)24-14/h3-7,9,23H,8H2,1-2H3
Key:YRJXUAYHZCDGDO-UHFFFAOYSA-N
α-Hydroxyetizolam is the pharmacologically active metabolite of etizolam .[ 2] [ 3]
Etizolam's other non-pharmacologically active metabolite in humans is 8-hydroxyetizolam.[ 2]
^ Fracasso C, Confalonieri S, Garattini S, Caccia S (1991-02-01). "Single and multiple dose pharmacokinetics of etizolam in healthy subjects". European Journal of Clinical Pharmacology . 40 (2): 181– 185. doi :10.1007/BF00280074 . PMID 2065698 . S2CID 10176681 . ^ a b "alpha-Hydroxyetizolam" . PubChem . U.S. National Library of Medicine. Retrieved 2021-02-23 .^ Nakamae T, Shinozuka T, Sasaki C, Ogamo A, Murakami-Hashimoto C, Irie W, et al. (November 2008). "Case report: Etizolam and its major metabolites in two unnatural death cases". Forensic Science International . 182 (1– 3): e1-6. doi :10.1016/j.forsciint.2008.08.012 . PMID 18976871 .
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