Forster–Decker method
The Forster–Decker method is a series of chemical reactions that have the effect of mono-alkylating a primary amine (1), forming a secondary amine (6).[1][2] The process occurs by way of transient formation of an imine (3) that undergoes the actual alkylation reaction.
Process stages
- Conversion of the primary amine to an imine (Schiff base) using an aldehyde.[3]
- Alkylation of the imine using an alkyl halide, forming an iminium ion.[4]
- Hydrolysis of the iminium, releasing the secondary amine and regeneratinf the aldehyde. [5]
See also
References
- ^ Forster, Martin Onslow (1899). "XCI.–Influence of substitution on specific rotation in the bornylamine series". Journal of the Chemical Society, Transactions. 75: 934–935. doi:10.1039/CT8997500934.
- ^ Decker, H.; Becker, P. Ann. 1913, 395, 362.
- ^ McMurry, John (1988). Organic Chemistry (Second ed.). Brooks/Cole Publishing Company. p. 674-675. ISBN 0-534-07968-7.
- ^ "Forster-Decker Amine Synthesis". SynArchive.com The Organic Synthesis Archive. 2011–2022. Retrieved December 12, 2022.
- ^ "Imine and Enamine Hydrolysis Mechanism". Chemistry Steps. 2016–2022. Retrieved December 13, 2022.
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