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Adrian Walter Gelb
Occupation(s)Anesthesiologist, academic, and author
Academic background
EducationMBChB
FRCPC
Alma materUniversity of Cape Town
University of Toronto
Academic work
InstitutionsUniversity of Western Ontario
University of California, San Francisco

Adrian Walter Gelb is an anesthesiologist, academic, and author. He is a professor emeritus in the Department of Anesthesia and Perioperative Care at the University of California, San Francisco.

Gelb's research has addressed anesthetic pharmacology and anesthetic techniques in relation to neurosurgery and cerebral ischemia, alongside broader work on global health. He received a Gold Medal for his contributions to anesthesia from the Canadian Anesthesiologists Society in 2018 and the Nicholas Greene MD Humanitarian Award from the American Society of Anesthesiologists in 2024.

Gelb is an elected Fellow of the Royal College of Anaesthetists and was awarded honorary membership to the German Society of Anaesthesiology.

Education and early career

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Gelb earned an MBChB from the University of Cape Town in 1972, followed by clinical training in South Africa and the UK.[1] He received his FRCPC in Anesthesia in 1979 and completed a research fellowship at the Mayo Clinic in 1980.[2]

Career

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Gelb began his academic career at the University of Western Ontario, initially as a lecturer. He was appointed assistant professor in 1982, associate professor in 1986, and professor of Anesthesia in 1991, a position he held until 2004.[3] He chaired the Department of Anesthesia and Perioperative Medicine from 1990 to 2001.[4] In 2004, he joined the University of California, San Francisco as a professor and vice chair in the Department of Anesthesia and Perioperative Care,[3] where he was later named professor emeritus.[1]

Gelb worked as an associate scientist at the Robarts Research Institute between 1987 and 1997, while also taking on positions as chief of anesthesia at University Hospital, then at London Health Sciences Centre and St. Joseph’s Health Centre.[3]

Gelb was appointed chair of the Patient Safety and Quality Committee of the World Federation of Societies of Anaesthesiologists (WFSA), since when he has worked with the World Health Organization, and helped develop International Standards for a Safe Practice of Anesthesia and an associated checklist, as well as metrics for evaluating surgical services.[5][6] He has held roles in organizations such as the International Anesthesia Research Society,[7] and the WFSA, where he was elected president from 2020 to 2022.[8]

Research

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Gelb’s research has focused on neuroanesthesia, neuropharmacology, neurophysiological monitoring, perioperative neurological dysfunction, and global health aspects of perioperative care, including health policy and patient safety.[3] He observed that perioperative stroke after noncardiac, nonneurosurgical surgery occurs more often than expected (0.05–0.7%), mostly embolic and post-anesthesia, not intraoperatively, with higher mortality linked to delayed diagnosis and combined inflammatory effects.[9][10] He co-developed and validated a contrast-enhanced CT method that measured cerebral blood flow and blood volume, including in brain tumors, where it distinguished tumor tissue from surrounding regions with strong agreement to the microsphere reference method.[11][12] Moreover, analyzing how loss of consciousness from anesthesia reduces beta-band oscillatory communication between the motor cortex and subcortical motor regions, he highlighted the role of frequency-specific brain interactions in normal motor function.[13]

In a collaborative study, Gelb investigated whether stimulation of the human insular cortex elicits cardiovascular responses and revealed lateralized autonomic control, with right-sided dominance for sympathetic effects.[14] His research evaluated the timing, clinical presentation, and characteristics of postoperative myocardial infarction (PMI) in at-risk patients undergoing noncardiac surgery, finding that PMIs typically occurred within the first two days postoperatively, were often not accompanied by chest pain, and were usually non-Q wave in nature.[15]

In neuroanesthesia, Gelb studied the interaction of anesthetic agents and cerebral ischemia,[16] the use of evoked potential monitoring,[17] and the influence of GABAergic agents on neurological examination in patients with supratentorial tumors, as well as the reversibility of midazolam effects.[18]

Awards and honors

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  • 2001 – Elected Fellow, Royal College of Anaesthetists, UK[19]
  • 2009 – Special Award for Contributions to the Development of Anesthesia in China, Chinese Society Anesthesia[3]
  • 2010 – Distinguished Service Award, Society for Neuroscience in Anesthesia and Critical Care (SNACC)[20]
  • 2016 – Honorary Membership, Czech Society of Anesthesia, Intensive Care, and Resuscitation[21]
  • 2018 – Gold Medal, Canadian Anesthesiologists Society[22]
  • 2020 – Honorary Membership, German Society of Anaesthesiology[23]
  • 2024 – Nicholas Greene MD Humanitarian Award, American Society of Anesthesiologists[24]
  • 2025 – Honorary Membership, Romanian Society of Anaesthesia and Intensive Care[25]

Bibliography

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Selected books

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  • Sharpe, Michael D.; Gelb, Adrian W. (1999). Anesthesia and Transplantation (1st ed.). Butterworth-Heinemann. ISBN 9780750696647.
  • Gupta, Arun K.; Gelb, Adrian W.; Duane, Derek; Adapa, Ram (2018). Essentials of Neuroanesthesia and Neurointensive Care (2nd ed.). Cambridge University Press. ISBN 9781316602522.

Selected articles

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References

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  1. ^ a b "UCSF Health–Adrian Gelb". University of California San Francisco. Retrieved May 23, 2025.
  2. ^ "UCSF Profiles–Adrian Gelb, MBBS". University of California San Francisco. Retrieved May 23, 2025.
  3. ^ a b c d e "UCSF–Gelb CV May 2025". UCSF. Retrieved June 5, 2025.
  4. ^ "Anesthesia and Perioperative Medicine–Department Chairs". University of Western Ontario. Retrieved May 23, 2025.
  5. ^ Patil, Priti; Nathani, Priyansh; Bakker, Juul M.; van Duinen, Alex J.; Bhushan, Pranav; Shukla, Minal; Chalise, Samir; Roy, Nobhojit; Gadgil, Anita (2023). "Are LMICs Achieving the Lancet Commission Global Benchmark for Surgical Volumes? A Systematic Review". World Journal of Surgery. 47 (8): 1930–1939. doi:10.1007/s00268-023-07029-x. PMC 10310578. PMID 37191692.
  6. ^ Harfaoui, Wafaa; Ziani, Hicham; Slaihi, Zakaria; Arfaoui, Manal; Armel, Bouchra; Elhamzaoui, Hamza; Belyamani, Lahcen; Alilou, Mustapha; Obtel, Majdouline (2024). "Compliance With World Health Organization (WHO)-World Federation of Societies of Anesthesiologists (WFSA) Standards for General Anesthesia at Ibn Sina University Hospital Center, Morocco". Cureus. 16 (1): e51980. doi:10.7759/cureus.51980. PMC 10853607. PMID 38344478.
  7. ^ "IARS–Leadership". International Anesthesia Research Society. Retrieved May 23, 2025.
  8. ^ "WFSA–Past Presidents". World Federation of Societies of Anaesthesiologists. Retrieved May 23, 2025.
  9. ^ Peng, Mengyuan; Ling, Xiaomin; Song, Ruixue; Gao, Xuan; Liang, Zhifeng; Fang, Fang; Cang, Jing (2019). "Upregulation of GLT-1 via PI3K/Akt Pathway Contributes to Neuroprotection Induced by Dexmedetomidine". Frontiers in Neurology. 10: 1041. doi:10.3389/fneur.2019.01041. PMC 6776610. PMID 31611842.
  10. ^ Marcucci, Maura; Chan, Matthew T V; Smith, Eric E; Absalom, Anthony R; Devereaux, P J (October 2023). "Prevention of perioperative stroke in patients undergoing non-cardiac surgery". The Lancet Neurology. 22 (10): 946–958. doi:10.1016/S1474-4422(23)00209-0. PMID 37739575.
  11. ^ Higashida, Randall T.; Furlan, Anthony J.; et al. (2003). "Trial Design and Reporting Standards for Intra-Arterial Cerebral Thrombolysis for Acute Ischemic Stroke". Stroke. 34 (8): e109-37. doi:10.1161/01.STR.0000082721.62796.09. PMID 12869717.
  12. ^ Latchaw, Richard E.; Alberts, Mark J.; Lev, Michael H.; Connors, John J.; Harbaugh, Robert E.; Higashida, Randall T.; Hobson, Robert; et al. (2009). "Recommendations for Imaging of Acute Ischemic Stroke: A Scientific Statement From the American Heart Association". Stroke. 40 (11): 3646–3678. doi:10.1161/STROKEAHA.108.192616. PMID 19797189.
  13. ^ Malekmohammadi, Mahsa; Price, Collin M; Hudson, Andrew E; DiCesare, Jasmine A T; Pouratian, Nader (2019). "Propofol-induced loss of consciousness is associated with a decrease in thalamocortical connectivity in humans". Brain. 142 (8): 2288–2302. doi:10.1093/brain/awz169. PMC 6931391. PMID 31236577.
  14. ^ Nolde, Janis M.; Rau, Alexander; Kellner, Elias; Urbach, Horst; Weiller, Cornelius; Bamberg, Fabian; Weiss, Jakob; Reisert, Marco; Hosp, Jonas A. (August 2025). "Microstructural integrity of autonomic central nervous tracts is linked to cardiovascular health". Neurobiology of Disease. 212: 106972. doi:10.1016/j.nbd.2025.106972. PMID 40441365.
  15. ^ Devereaux, P.J.; Xavier, Denis; Pogue, Janice; Guyatt, Gordon; Sigamani, Alben; Garutti, Ignacio; Leslie, Kate; Rao-Melacini, Purnima; Chrolavicius, Sue; Yang, Homer; MacDonald, Colin; Avezum, Alvaro; Lanthier, Luc; Hu, Weijiang; Yusuf, Salim (2011). "Characteristics and Short-Term Prognosis of Perioperative Myocardial Infarction in Patients Undergoing Noncardiac Surgery: A Cohort Study". Annals of Internal Medicine. 154 (8): 523–528. doi:10.7326/0003-4819-154-8-201104190-00003. PMID 21502650.
  16. ^ Statler, Kimberly D.; Alexander, Henry; Vagni, Vincent; Dixon, C. Edward; Clark, Robert S. B.; Jenkins, Larry; Kochanek, Patrick M. (2006). "Comparison of Seven Anesthetic Agents on Outcome after Experimental Traumatic Brain Injury in Adult, Male Rats". Journal of Neurotrauma. 23 (1): 97–108. doi:10.1089/neu.2006.23.97. PMID 16430376.
  17. ^ Wilent, W. Bryan; Tesdahl, Eric A.; Trott, Julie T.; Tassone, Shakira; Harrop, James S.; Klineberg, Eric O.; Sestokas, Anthony K. (November 2021). "Impact of inhalational anesthetic agents on the baseline monitorability of motor evoked potentials during spine surgery: a review of 22,755 cervical and lumbar procedures". The Spine Journal. 21 (11): 1839–1846. doi:10.1016/j.spinee.2021.07.002. PMID 34274500.
  18. ^ Lee, Chanhung Z.; Poon, Clara C. M. (January 2022). "An Update of Neuroanesthesia for Intraoperative Brain Mapping Craniotomy". Neurosurgery. 90 (1): 1–6. doi:10.1093/neuros/nyab022. PMID 33647962.
  19. ^ "Criteria for Honours, Awards and Prizes" (PDF). Royal College of Anaesthetists. Retrieved May 23, 2025.
  20. ^ "SNACC–Distinguished Service Award". SNACC. Retrieved June 5, 2025.
  21. ^ "Čestná členství ČSARIM". ČSARIM. Retrieved May 23, 2025.
  22. ^ "Canadian Anesthesiologists Society–Gold Award Past Winners". Canadian Anesthesiologists Society. Retrieved May 23, 2025.
  23. ^ "Ehrenmitgliedschaft". DGAI. Retrieved May 23, 2025.
  24. ^ "American Society of Anesthesiologists–Humanitarian Award". American Society of Anesthesiologists. Retrieved May 23, 2025.
  25. ^ "WFSA leaders honoured at SRATI Congress". WFSA. 17 May 2025. Retrieved June 5, 2025.
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