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Heinz Falk

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Heinz Falk

Heinz Falk (* 29. April 1939 in Sankt Pölten) ist ein österreichischer Chemiker, Emeritus für Organische Chemie an der Johannes Kepler Universität Linz, Redakteur der Serie „Progress in the Chemistry of Organic Natural Compounds“ [1] und Herausgeber der „Monatshefte Chemie/Chemical Monthly“ des Springer-Verlags[2].

Falks Forschungsschwerpunkt sind die Strukturanalyse, Synthese, Stereochemie und Photochemie von pflanzlichen und tierischen lichtempfindlichen Farbstoffen, wie z.B. Hypericin[3].

Leben

Heinz Falk wurde am 29. April 1939 in Sankt Pölten geboren, besuchte die Volksschule in Statzendorf und anschließend die Hauptschule in Krems an der Donau. Nachdem er 1953 nach Wien übersiedelte, absolvierte er die Höhere Bundeslehr- und Versuchsanstalt für chemische Industrie in der Rosensteingasse und machte anschließend in 1959 die Matura in der Abendschule, wo er auch seine zukünftige Frau, Rotraud Falk (geb. Strohbach) kennenlernte.

Heinz Falk ist seit 1966 verheiratet mit Rotraud Falk und sie haben einen Sohn (Alexander Falk, CEO des Softwareunternehmens Altova).

Heinz Falk begann 1959 sein Studium der Chemie an der Universität Wien und promovierte 1966 (Dissertation bei Karl Schlögl). In der Folge verbrachte Falk das Jahr 1971 im Rahmen eines Auslandsaufenthaltes an der ETH Zürich. Nach seiner Rückkher nach Wien erreichter er 1972 die Habilitation und damit die Lehrbefugnis für Organische Chemie an der Universität Wien.

Karriere

1966-1979

Seit 1966 war Falk als Assistent am Institut für Organische Chemie an der Universität Wien tätig. 1975 wurde er zum außerordentlichen Professor für Physikalische Organische Chemie an der Universität Wien berufen. Im Sommer 1978 wurde Falk als Vortragender zur Gordon Research Conference in Wolfeboro eingeladen.

seit 1979

1979 nahm Falk eine Berufung zum ordentlichen Professor für Organische Chemie an der Johannes Kepler Universität Linz an, und baute dort das neue Institut für Organische Chemie auf. Von 1989 bis 1991 war er Dekan der Technisch-Naturwissenschaftlichen Fakultät. Im Jahr 2005 wurde Falk von den OÖ Nachrichten als #3 unter den Top-10-Wissenschaftlern in Oberösterreich genannt[4].

Falks Forschungsschwerpunkt sind die Strukturanalyse, Synthese, Stereochemie und Photochemie von pflanzlichen und tierischen lichtempfindlichen Farbstoffen. Die wichtigste Gruppe der organischen Verbindungen sind dabei Farbsoffe die sich vom phenanthro[1,10,9,8-opqra]perylene-7,14-dione Chromophor ableiten, wie z.B. die natürlichen Farbstoffe Hypericin, Stentorin, die Fringelite, die Gymnochrome und Blepharismin. Darüberhinaus behandelt Falk die Hemin-analogen Corrphycene Derivative (z.B. als potentielle Blutersatz und Heme-Oxygenase-blocker) sowie andere natürliche Verbindungen wie z. B. den natürlichen Sonnenschutzfaktor urocanic acid.

Werke

Bücher

  • Heinz Falk: Ausgewählte Übungsbeispiele Zur Nomenklatur Organischer Verbindungen. Springer-Verlag, Wien, New York 1978, ISBN 0-387-81479-5.
  • Heinz Falk: The Chemistry of Linear Oligopyrroles and Bile Pigments. Springer-Verlag, Wien, New York 1989, ISBN 0-387-82112-0.

Wissenschaftliche Publikationen

  • H. Marko, N. Mueller und H. Falk, Nuclear Magnetic Resonance Investigations of the Biliverdin/Apomyoglobin Complex. Eur. J. Biochem. 193, 573 (1990)
  • H. Falk, H. Marko, N. Mueller, W. Schmitzberger und H. Stumpe, Reconstitution of Apomyoglobin with Bile Pigments. Monatsh. Chem. 121, 893 (1990)
  • H. Falk, H. Marko, N. Mueller und W. Schmitzberger, On the Chemistry of Pyrrole Pigments 87.Mitt.: The Apomyoglobin Heme Pocket as a Reaction Vessel in Bile Pigment Chemistry. Monatsh. Chem. 121, 903 (1990)
  • H. Falk und H. Marko, Reduction of a Bilindione-10-Thiol-Adduct as a Model for the Reduction Step of the Biliverdin Reductase System. Monatsh. Chem. 122, 319 (1991)
  • U. Wagner, C. Kratky, H. Falk und H. Woess, Crystal Structure and Conformation of 10-Aryl-bilatrienes-abc. Monatsh. Chem. 122, 749 (1991)
  • H. Falk und G. Schoppel, A Synthesis of Emodin Anthrone. Monatsh. Chem. 122, 739 (1991)
  • H. Falk and W. Schmitzberger, On the Nature of "Soluble" Hypericin in Hypericum Species. Monatsh. Chem., 123, 731 (1992)
  • H. Falk and D. Hemmer, On the Chemistry of Pyrrole Pigments, 88. Mitt.: Nonlinear Optical Properties of Linear Oligopyrroles. Monatsh. Chem. 123, 779 (1992)
  • H. Falk and G. Schoppel, On the Synthesis of Hypericin by Oxidative Trimethylemodin Anthrone and Emodin Anthrone Dimerization: Isohypericin. Monatsh. Chem. 123, 931 (1992)
  • H. Falk and W. Schmitzberger, On the Bromination of Hypericin: The Gymnochrome Chromophores. Monatsh. Chem. 124, 77 (1993)
  • C. Etzlstorfer, H. Falk, N. Mueller, W. Schmitzberger and U. Wagner, Tautomerism and Stereochemistry of Hypericin: Force Field, NMR, and X-ray Crystallographic Investigations. Monatsh. Chem., 124, 751 (1993)
  • H. Falk and A. Suste, On the Chemistry of Pyrrole Pigments, XC: Pyridinologous Linear Tri- and Tetrapyrroles. Monatsh. Chem., 124, 881 (1993)
  • H. Falk, J. Meyer and M. Oberreiter, A Convenient Semisynthetic Route to Hypericin. Monatsh. Chem., 124, 339 (1993)
  • C. Etzlstorfer and H. Falk, Tautomerism and Stereochemistry of Isohypericin, Bromo-hypericines, and Gymnochromes: Force Field Investigations. Monatsh. Chem., 124, 1031 (1993)
  • H. Pschierer, J. Friedrich, H. Falk and W. Schmitzberger, On the Correlation Between Pressure Shift and Solvent Shift: A Spectral Hole Burning Study. J. Phys. Chem., 97, 6902 (1993)
  • A. Angerhofer, H. Falk, J. Meyer and G. Schoppel, The Lowest Triplet States of Hypericin and Isohypericin. J. Photochem. Photobiol., B20, 133 (1993)
  • H. Falk and A. Suste, On the Chemistry of Pyrrole Pigments, XCI: Copper Complexes of Pyridinologous Linear Tri- and Tetrapyrroles as Cyclopropanation Catalysts. Monatsh. Chem., 125, 325 (1994)
  • H. Falk and J. Meyer, On the Homo- and Heteroassociation of Hypericin. Monatsh. Chem., 125, 753 (1994)
  • C. Etzlstorfer and H. Falk, Stereochemistry and Tautomerism of Stentorin, Isostentorin, and Fringelit D: Force Field Investigations. Monatsh. Chem., 125, 955 (1994)
  • H. Falk, E. Mayr and A. Richter, Simple Diffuse Reflectance UV-Vis Spectroscopic Determination of Organic Pigments (Fringelites) in Fossils. Microchim. Acta, 117, 1 (1994)
  • H. Falk and J. Leimhofer, Ozone as an Oxygen Source for Alkene Ene-Reactions. Monatsh. Chem., 126, 85 (1995)
  • Q.-Q. Chen, H. Falk and R. Micura, On the Chemistry of Pyrrole Pigments, XCII: Syntheses of 1,2-Bis-pyrrolylethanes. Monatsh. Chem., 126, 473 (1995)
  • H. Falk, C. Kratky, N. Mueller, W. Schmitzberger and U. Wagner, Structure Determination of the Biliverdin Apomyoglobin Complex. Crystal Structure Analysis of Two Crystal Forms at 1.4 and 1.5 * Resolution. J. Mol. Biol., 247, 326 (1995)
  • N. H. Tran-Thi and H. Falk, An Efficient Synthesis of the Plant Growth Hormone 1-Triacontanol. Monatsh. Chem., 126, 565 (1995)
  • H. Falk and A. F. Vaisburg, Concerning the Absorption and Emission Properties of Phenanthro [1,10,9,8,o,p,q,r,a]perylene-7,14-dione. Monatsh. Chem., 126, 361 (1995)
  • H. Falk and E. Mayr, Syntheses and Properties of Fringelite D (1,3,4,6,8,10,11,13-octahydroxy-phenanthro[1,10,9,8,o,p,q,r,a]perylene-7,14-dione). Monatsh. Chem., 126, 699 (1995)
  • H. Falk, A.F. Vaisburg and A.M. Amer, On the Synthesis of w-Appended Hypericin Derivatives. Monatsh. Chem., 126, 993 (1995)
  • R. Altmann and H. Falk, On the Syntheses and Chiroptical Properties of the Tri- and Tetragalloylquinic Acids. Monatsh. Chem. 126, 1225 (195)
  • D. Shemin and H. Falk, Porphyrins and Bile Pigmens, Metabolism Encyclopedia of Human Biology, 2nd Ed., Academic Press, 177 (1996)
  • H. Falk and Q.-Q. Chen, On the Chemistry of Pyrrole Pigments, XCVI: An Efficient Synyhesis of Corrphycenes. Mh. Chem., 127, 69 (1996)
  • H. Falk and E. Mayr, Syntheses, Constitutions, and Properties of Stentorin and Isostentorin. Mh. Chem., 126, 1311 (1995)
  • H. Falk and T.N.H. Tran, Synthesis and Properties of an w,wÕ - Appended Eigtheen Carbon Chains Hypericin Derivative. Mh. Chem., 127, 717 (1996)
  • C. Etzlstorfer, H. Falk, N. Mueller and T.N.H. Tran, Structural Aspects and Electronic Absorption of the Hydroxyphenanthroperylene Quinones Fringelit D, Hypericin, and Stentorin. Mh. Chem., 127, 659 (1996)
  • C. Etzlstorfer, H. Falk, E. Mayr and S. Schwarzinger, Concerning the Acidity and Hydrogen Bonding of Hydroxyphenantroperylene Quinones, like Fringelite D, Hypericin, and Stentorin. Mh. Chem., 127,1229 (1996)
  • R. Altmann, C. Etzlstorfer and H. Falk, Chiroptical Properties and Absolute Configurations of the Hypericin Chromophore Propeller Enantiomers. Mh. Chem., 128, 785 (1997)
  • H. Falk and M. Stanek, Two-Dimensional 1H and 13C NMR Spectroscopy and the Structural Aspects of Amylose and Amylopectin. Mh. Chem., 128, 777 (1997)
  • H. Falk, A.A.O. Sarhan, H.T.N. Tran and R. Altmann, Synthesis and Properties of Hypericins Substituted with Acidic and Basic Residues: Hypericin Tetrasulfonic Acid – a Water Soluble Hypericin Derivative. Mh. Chem., 129, 309 (1998)
  • E.I. Kapinuns, H. Falk and T.N.H. Tran, Spectroscopic Investigaion of the Molecular Structures of Hypericin and its Salts. Mh. Chem., 130, 1237 - 1244 (1999)
  • A.M. Amer, H. Falk, H.N.T. Tran, The Dissociation and Tautomerization Equilibria of Hypericin: Alkyl Protected Hydroxyl Derivatives. Mh. Chem., 130, 623 - 635 (1999)
  • R. Obermüller, G. Schütz, H. Gruber and H. Falk, Concerning Regioselective Photochemical Intermolecular Proton Transfer from Hypericin. Mh. Chem., 130, 275 - 281 (1999)
  • G. Kada, H. Falk and H. Gruber, Accurate Measurement of Avidin and Streptavidin in Crude Biofluids with a New, Optimized Biotin. Fluorescein Conjugate. Biochim. Biophys. Acta, 1427, 33 - 43 (1999)
  • C. Etzlstorfer, I Gutman and H. Falk, Concerning the Deprotonation ot the Photooxidized 3-Hypericinate Ion. Mh. Chem., 130, 1333 - 1339 (1999)
  • T. Dax, H. Falk and E. Kapinus, A Structural Proof for the Hypericin 1,6-Dioxo Tautomer. Mh. Chem., 130, 827 - 831 (1999)
  • H. Falk, Gosau Schleifsteine für den Fossiliensammler. Fossilien, 4, 248 - 250 (1999)
  • H. Falk, Vom Photosensibilisator Hypericin zum Photorezeptor Stentorin - die Chemie der Phenanthroperylenchinone. Angew. Chemie, 111, 3306 - 3326 (1999)
  • H. Falk, From the Photosensibilisator Hypericin to the Photoreceptor Stentorin - the Chemistry of the Phenanthroperylene Quinones. Angew. Chemie Int. Ed., 38, 3134 - 3154 (1999)
  • S. Baumgartner, T. Dax, W. Praznik and H. Falk, Characterization of the high-molecular weight fructan isolated from garlic (Allium sativum L.). Carbohydrate Res., 328, 177-183 (2000)
  • C. Etzlstorfer and H. Falk, Concerning the Association of Hypericin Tautomers and their Hypericinate Ions. Mh. Chem., 131, 333-340 (2000)
  • T. Dax, E. Kapinus and H. Falk, A Remarkable Photoreaction of 3-O-Benzylhypericin. Helvetica Chimica Acta, 83, 1744-1752 (2000)
  • B. Immitzer, C. Etzlstorfer, R. Obermüller, M. Sonnleitner, G. Schütz, and H. Falk, On the Photochemical Proton Expulsion Capability of Fringelite D — A Model of the Protist Photosensory Pigments of the Stentorin and Blepharismin Types. Mh. Chem., 131, 1039-1045 (2000)
  • T. Dax, C. Etzlstorfer, and H. Falk, On the Ground State Energy Hypersurface of Blepharismins and Oxyblepharismins. Mh. Chem., 131, 1115-1122 (2000)
  • B. Immitzer and H. Falk, Fringelite D, a Model of the Protist Photosensory Pigments of the Stentorin and Blepharismin Types: the Hypericin and Fringelite D Photosensitized Destruction of Bilirubin. Mh. Chem., 131, 1167-1171 (2000)
  • T. Dax and H. Falk, An Unusual Photoreaction of 3,4,-Di-O-benzyl-hypericin. Mh. Chem., 131, 1217-1219 (2000)
  • E. Delaey, R. Obermüller, I. Zupko, H. Falk, and P. de Witte, In vitro Study of the Photocytotoxicity of some Hypericin analogs on different Cell Lines. Photochem. Photobiol., 74, 164-171 (2001)
  • R.A. Obermüller, K. Hohenthanner, and H. Falk, Towards Hypericin-Derived Potential Photdynamic Therapy Agents. Photochem. Photobiol., 74, 211-215 (2001)
  • B. Tu, Q. Chen, F. Yan, J. Ma, K. Grubmayr, and H. Falk, Efficient Routes to -Chloroalkyl Bilirubins and C12-N22 Bridged Biliverdins. Mh. Chem., 132, 693-705 (2001)
  • R.A. Obermüller, T. Dax and H. Falk, Replacement of Methoxy- to tert-Butyl-Substitution on a Napththalene Residue – An Unexpected Reaction Observed During a Snieckus ortho-Lithiation. Mh. Chem., 132, 1057-1062 (2001)
  • R.A. Obermüller and H. Falk, Concerning the Absorption and Photochemical Properties of an -4-Dimethylaminobenzal Hypericin Derivative. Mh. Chem., 132, 1519-1526 (2001)
  • R.A. Obermüller, C. Etzlstorfer and H. Falk, On the Chemistry of a Dibenzohypericin Derivative. Mh. Chem., 133, 89-96 (2002)
  • J. Leonhartsberger and H. Falk, The Protonation and Deprotonation Equilibria of Hypericin Revisited. Mh. Chem., 133, 167-172 (2002)
  • B. Lackner and H. Falk, Concerning the Diastereomerization of Stilbenoid Hypericin Derivatives. Mh. Chem., 133, 717-721 (2002)
  • T.N. Tran and H. Falk, Concerning the Chiral Discrimination and Helix Inversion Barrier in Hypericinates and Hypericin Derivatives. Mh. Chem., 133, 1231-1237 (2002)
  • M. Emsenhuber, P. Pöchlauer, J.-M. Aubry, V. Nardello and H. Falk, Evidence for the Generation of Singlet Oxygen (1O2, 1g) from Ozone Promoted by Inorganic Salts. Mh. Chem., 133, 387-391 (2003)
  • M. Deak and H. Falk, On the Chemistry of the Resveratrol Diastereomers. Mh. Chem., 134, 883-888 (2003)
  • T.A. Salama, B. Lackner and H. Falk, An Efficient Synthesis of O-Methyl Protected Emodin Aldehyde and Emodin Nitrile. Mh. Chem., 134, 1113-1119 (2003)
  • Bettina Schwarzinger, and Heinz Falk, A Unique Photoreaction of Hypericinate Bound to Human Serum Albumin, Lipids, or Vesicles. Mh. Chem., 134, 1353-1358 (2003)
  • Beate Hager, Mario Alva-Astudillo, and Heinz Falk, A Hemin-Analogous Corrphycene Derivative: Suppression of Heme Oxygenase and Reconstitution with Apomyoglobin. Mh. Chem., 134, 1499-1507 (2003)
  • Tarek A. Salama, Bernd Lackner, and Heinz Falk, Synthesis of 6-Heterocyclically Appendend Tri-O-Methyl Protected 6-Desmethyl Emodin Derivatives. Mh. Chem., 135, 735-742 (2004)
  • Thorsten Ganglberger, Walther G. Jary, Peter Pöchlauer, Jean-Marie Aubry, Veronique Nardello, and Heinz Falk, A Chemical (Dark) Source of Singlet Oxygen: Ozone Splitting Promoted by Tin(II) Salts. Mh. Chem., 135, 501-507 (2004)
  • Walther G. Jary, Thorsten Ganglberger, Peter Pöchlauer, and Heinz Falk, Generation of Singlet Oxyen from Ozone Catalysed by Phosphinofer-rocenes. Mh. Chem., 136, 537-541 (2005)
  • Bernd Lackner, Christoph Etzlstorfer and Heinz Falk, Synthesis and Properties of 10,11-Dibenzimidazolyl-10,11-didesmethyl-hypericin – The First Heterocyclically Substituted Hypericin Derivative. Mh. Chem., 135, 1157-1166 (2004)
  • Bettina Schwarzinger and Heinz Falk, Concerning the Photodiastereomerization and Protic Equilibria of Urocanic Acid and its Complex with Human Serum Albumin. Mh. Chem., 135, 1297-1304 (2004)
  • Mario Waser, Heinz Falk, Peter Pöchlauer and Walther G. Jary, Concerning Chemistry, Reactivity, and Mechanism of Transition Metal Catalysed Oxidation of Benzylic Compounds by Means of Ozone. Journal of Molecular Catalysis A - Chemical, , 236, 187-193 (2005)
  • Mario Waser and Heinz Falk, Intramolecularly Friedel-Crafts Acylated Emodin Derivatives: An Access to the Cores of Angucyclinones, Anthracyclinones, and to Hypericin Analogues. Mh. Chem., 136, 609-618 (2005)
  • Bernd Lackner, Yulita Popova, Christiph Etzlstorfer, Andrija A. Smelcerovic, Christian W. Klampfl, and Heinz Falk, Syntheses and Properties of Two Heterocyclically Substituted Hypericin Derivatives: 10,11-Dibenzothiazolyl-10,11-didesmethyl-hypericin and 10,11-Dibenzoxazolyl-10,11-didesmethylhypericin. Mh. Chem., 136, 777-793 (2005)
  • Mario Waser, Bernd Lackner, Joachim Zuschrader, Norbert Müller, and Heinz Falk, An efficient regioselective synthesis of endocrocin and structural related natural anthraquinones starting from emodin. Tetrahedron Lett., 46, 2377-2380 (2005)
  • Bernd Lackner, Klaus Bretterbauer, and Heinz Falk, An Efficient Route to Emodic Amine and Analogous O-Methyl Protected Derivatives Starting from Emodin. Mh. Chem., 136, 1629-1639 (2005)
  • Mario Waser, Yulita Popova, Christoph Etzlstorfer, Werner F. Huber, and Heinz Falk, Syntheses, Photochemical Properties, and Tautomerism of Intramolecularly Friedel-Crafts Acylated Hypericin Derivatives. Mh. Chem., 136, 1221-1231 (2005)
  • David Geißlmeir, Walther G. Jary and Heinz Falk, The TEMPO/Copper Catalyzed Oxidation of Primary Alcohols to Aldehydes Using Oxygen as Stoichometric Oxidant. Mh. Chem., 136, 1591-1599 (2005)
  • Mario Waser, Yulita Popova, Christian W. Klampfl, and Heinz Falk, 9,12-Dibenzothiazolylhypericin and 10,11-Dibenzothiazolyl-10,11-Didemethylhypericin: Photochemical Properties of Hypericin Derivatives Depending on the Substitution Site. Mh.Chem., 136, 1791-1797 (2005)
  • Klaus Wolkenstein, Jürgen H. Gross, Heinz Falk, and Heinz F. Schöler, Preservation of hypericin and related polycyclic quinone pigments in fossil crinoids. Proceedings of the Royal Society B, 273, 451-456 (2006)
  • Beate Hager, Bettina Schwarzinger and Heinz Falk, Concerning the Thermal Diastereomerization of the Green Fluorescent Protein Chromophore. Mh. Chem., 137, 163-168 (2006)
  • Mario Waser and Heinz Falk, Condensed Emodin Derivatives and Their Applicability for the Synthesis of a Fused Heterocyclic Hypericin Derivative. Eur. J. Org. Chem., 1200-1206 (2006)
  • Mario Waser and Heinz Falk, Towards Second Generation Hypericin Based Photosensitizers for Photodynamic Therapy. Curr. Org. Chem. 11: 547-558 (2007)
  • Heinz Falk: Karl Schlögl. Obituary. Mh. Chem., 138 (2007)
  • Karoline Fendler, Beate Hager, and Heinz Falk, The Thermal Diastereomerization of the Tryptophane-Derived Green Fluorescent Protein Chromophore. Mh. Chem., 138, 859-862 (2007)
  • Mieke Roelants, Heinz Falk, Bernd Lackner, Mario Waser, Peter A.M. de Witte, OC222 Bathochromically shifted hypericin derivatives: photosensitizing properties. Abstr. of 12th Congress of the Europaean Society for Photobiology 2007, University of Bath, UK, Sept 1/6, (2007)
  • Heinz Falk, Die 44. Mineralientage München - ein Rückblick. Fossilien, 25, 2-4 (2008)
  • Heinz Falk. Karl Schlögl, Nachruf. Almanach d. Öst. Akademie der Wiss. , 157, 469-477 (2008)

Patente

Auszeichnungen

Einzelnachweise

  1. ↑ Springer Wien/New York, Progress in the Chemistry of Organic Natural Compounds
  2. ↑ Springer Wien/New York, Chemical Monthly, Editorial Board
  3. ↑ Hypericin-Gruppe am Institut für Organische Chemie
  4. ↑ OÖ Nachrichten - Best of OÖ Teil 18: Die klügsten Köpfe
  5. ↑ Österreichische Akademie der Wissenschaften, Mitglieder
  6. ↑ Johannes Kepler Universität - News vom Campus, Ausgabe 22, März 2004
  7. ↑ Gesellschaft Österreichischer Chemiker, Hall of Fame
  8. ↑ Österreichische Akademie der Wissenschaften, Member details
  9. ↑ Rudolf Trauner Stiftung, Wissenschaftspreis 2003
Personendaten
NAME Falk, Heinz
KURZBESCHREIBUNG österreichischer Chemiker
GEBURTSDATUM 29. April 1939
GEBURTSORT Sankt Pölten
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