Genomoviridae is a family of single stranded DNA viruses. The genomes of this family are small (2.2-2.4 kilobases in length). The genomes are circular single-stranded DNA and encode rolling-circle replication initiation proteins (Rep) and unique capsid proteins. In Rep-based phylogenies, genomoviruses form a sister clade to plant viruses of the family Geminiviridae.[1][2] Nine genera are currently recognized in this family.
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The family name is an acronym derived from geminivirus-like, no movement protein.
The genus name Gemycircularvirus stands for Gemini-like myco-infecting circular virus.[3][4] The type species of the genus Gemycircularvirus - Sclerotinia sclerotiorum hypovirulence associated DNA virus 1 - is currently the only cultivated member of the family.[1] The other genomoviruses are uncultivated and have been discovered using metagenomics techniques.[2]
Taxonomy
The genera in this family are:[2]
- Gemycircularvirus - 73 species
- Gemyduguivirus - 1 species
- Gemygorvirus - 9 species
- Gemykibivirus - 29 species
- Gemykolovirus - 3 species
- Gemykrogvirus - 3 species
- Gemykroznavirus - 1 species
- Gemytondvirus - 1 species
- Gemyvongvirus - 1 species
Biology
These viruses have single stranded genomes of 2.1-2.2 kilobases in length. The genome encodes two proteins - a Rep (replicator) and a CP (capsid) protein. The Rep protein has some homology with the Rep protein of the Geminiviridae. In contrast the CP protein has no known homologies.
References
- ↑ a b Krupovic M, Ghabrial SA, Jiang D, Varsani A: Genomoviridae: a new family of widespread single-stranded DNA viruses. In: Arch Virol. 161. Jahrgang, Nr. 9, 2016, S. 2633–2643, doi:10.1007/s00705-016-2943-3, PMID 27343045 (springer.com).
- ↑ a b c Arvind Varsani, Mart Krupovic: Sequence-based taxonomic framework for the classification of uncultured single-stranded DNA viruses of the family Genomoviridae. In: Virus Evolution. 3. Jahrgang, Nr. 1, 2017, S. vew037, doi:10.1093/ve/vew037 (oup.com).
- ↑ Rosario K, Dayaram A, Marinov M, Ware J, Kraberger S, Stainton D, Breitbart M, Varsani A: Diverse circular ssDNA viruses discovered in dragonflies (Odonata: Epiprocta). In: J Gen Virol. 93. Jahrgang, Nr. 12, 2012, S. 2668–81, doi:10.1099/vir.0.045948-0, PMID 22915694 (sgmjournals.org).
- ↑ Yu X, Li B, Fu Y, Jiang D, Ghabrial SA, Li G, Peng Y, Xie J, Cheng J, Huang J, Yi X: A geminivirus-related DNA mycovirus that confers hypovirulence to a plant pathogenic fungus. In: Proc Natl Acad Sci USA. 107. Jahrgang, Nr. 18, 2010, S. 8387–92, doi:10.1073/pnas.0913535107, PMID 20404139, PMC 2889581 (freier Volltext).