C-Myc

c-Myc
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 1A93、​1EE4、​1MV0、​1NKP、​2A93、​2OR9、​4Y7R
識別號
别名	MYC；, MRTL, MYCC, bHLHe39, c-Myc, v-myc avian myelocytomatosis viral oncogene homolog, MYC proto-oncogene, bHLH transcription factor, Genes, myc, c-myc
外部ID	OMIM：190080 MGI：97250 HomoloGene：31092 GeneCards：MYC
基因位置（人类） 染色体 8號染色體 基因座 8q24.21 起始 127,735,434 bp 终止 127,742,951 bp
基因位置（小鼠） 染色体 小鼠15号染色体 基因座 15 D1|15 26.19 cM 起始 61,857,240 bp 终止 61,862,223 bp
基因本體 分子功能 • DNA结合 • protein dimerization activity • DNA结合转录因子活性 • DNA-binding transcription activator activity, RNA polymerase II-specific • 转录因子结合 • RNA polymerase II cis-regulatory region sequence-specific DNA binding • E-box binding • 血浆蛋白结合 • 大分子复合物结合 • DNA-binding transcription factor activity, RNA polymerase II-specific • DNA结合转录阻遏物活性，RNA聚合酶II特异性 細胞組分 • 核质 • 核仁 • 细胞核 • 大分子复合体 生物學過程 • Notch信号通路 • 染色体重建 • negative regulation of monocyte differentiation • positive regulation of metanephric cap mesenchymal cell proliferation • regulation of transcription, DNA-templated • regulation of telomere maintenance • positive regulation of epithelial cell proliferation • positive regulation of fibroblast proliferation • cellular response to UV • oxygen transport • negative regulation of apoptotic process • negative regulation of transcription by RNA polymerase II • chromosome organization • MAPK cascade • cellular response to DNA damage stimulus • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • branching involved in ureteric bud morphogenesis • negative regulation of cell division • fibroblast apoptotic process • positive regulation of mesenchymal cell proliferation • positive regulation of response to DNA damage stimulus • positive regulation of cell population proliferation • positive regulation of DNA biosynthetic process • 基因調節 • canonical Wnt signaling pathway • negative regulation of stress-activated MAPK cascade • energy reserve metabolic process • response to growth factor • response to gamma radiation • negative regulation of fibroblast proliferation • positive regulation of transcription by RNA polymerase II • cellular iron ion homeostasis • beta-catenin-TCF complex assembly • transcription, DNA-templated • transcription by RNA polymerase II • regulation of transcription by RNA polymerase II • protein deubiquitination • positive regulation of transcription, DNA-templated • positive regulation of telomerase activity • positive regulation of gene expression • protein-DNA complex disassembly • ERK1 and ERK2 cascade • cellular response to hypoxia • G1/S transition of mitotic cell cycle • cytokine-mediated signaling pathway • positive regulation of DNA methylation Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	4609	17869
Ensembl	ENSG00000136997	ENSMUSG00000022346
UniProt	P01106	P01108
mRNA​序列	NM_002467 ​NM_001354870	NM_001177352 ​NM_001177353 ​NM_001177354 ​NM_010849
蛋白序列	NP_002458 ​NP_001341799	NP_001170823 ​NP_001170824 ​NP_001170825 ​NP_034979
基因位置​（UCSC）	Chr 8: 127.74 – 127.74 Mb	Chr 15: 61.86 – 61.86 Mb
PubMed​查找
維基數據
檢視/編輯人類 檢視/編輯小鼠

C-Myc或Myc是编码转录因子的调节基因。这一基因编码的蛋白在细胞核内被磷酸化，有多种功能：在细胞周期进程、细胞凋亡和细胞轉化中发挥作用。