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Signal-recognition-particle GTPase

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Signal-recognition-particle GTPase
Identifiers
EC no.3.6.5.4
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BRENDABRENDA entry
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Signal-recognition-particle GTPase (EC 3.6.5.4) is an enzyme with systematic name GTP phosphohydrolase (protein-synthesis-assisting).[1][2][3][4] This enzyme catalyses the following chemical reaction

GTP + H2O GDP + phosphate

Enzyme activity is associated with the signal-recognition particle.

See also

References

  1. ^ Connolly T, Gilmore R (May 1989). "The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide". Cell. 57 (4): 599–610. doi:10.1016/0092-8674(89)90129-3. PMID 2541918.
  2. ^ Connolly T, Rapiejko PJ, Gilmore R (May 1991). "Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor". Science. 252 (5009): 1171–3. Bibcode:1991Sci...252.1171C. doi:10.1126/science.252.5009.1171. PMID 1851576.
  3. ^ Miller JD, Wilhelm H, Gierasch L, Gilmore R, Walter P (November 1993). "GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation". Nature. 366 (6453): 351–4. Bibcode:1993Natur.366..351M. doi:10.1038/366351a0. PMID 8247130.
  4. ^ Freymann DM, Keenan RJ, Stroud RM, Walter P (January 1997). "Structure of the conserved GTPase domain of the signal recognition particle". Nature. 385 (6614): 361–4. Bibcode:1997Natur.385..361F. doi:10.1038/385361a0. PMID 9002524.