LEFTY2

LEFTY2
Identifiers
Aliases	LEFTY2, EBAF, LEFTA, LEFTYA, TGFB4, left-right determination factor 2
External IDs	OMIM: 601877; MGI: 2443573; HomoloGene: 2434; GeneCards: LEFTY2; OMA:LEFTY2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	225,941,383 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	180,726,668 bp
RNA expression pattern
	Top expressed in
	decidua; ; body of uterus; ; Epithelium of choroid plexus; ; myometrium; ; sperm; ; left ovary; ; canal of the cervix; ; Descending thoracic aorta; ; testicle; ; ascending aorta;
	Top expressed in
	mesoderm; ; lateral plate mesoderm; ; embryo; ; epiblast; ; Gonadal ridge; ; embryo; ; neural plate; ; primitive streak; ; inner cell mass; ; paraxial mesoderm;
	More reference expression data
	n/a
Gene ontology
Molecular function	transforming growth factor beta receptor binding; cytokine activity; growth factor activity;
Cellular component	extracellular matrix; extracellular region; platelet alpha granule lumen; extracellular space; collagen-containing extracellular matrix;
Biological process	multicellular organism development; regulation of apoptotic process; positive regulation of pathway-restricted SMAD protein phosphorylation; cell growth; platelet degranulation; regulation of MAPK cascade; transforming growth factor beta receptor signaling pathway; SMAD protein signal transduction; cell development; BMP signaling pathway; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	7044
	320202
	ENSG00000143768
	ENSMUSG00000066652
	O00292
	P57785
	NM_001172425; NM_003240
	NM_177099
	NP_001165896; NP_003231
	NP_796073
	Wikidata
View/Edit Human	View/Edit Mouse

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Left-right determination factor 2 (Lefty2) aka TGFB4 is a protein that is encoded by the LEFTY2 gene in humans. ^[5]

Function

Lefty2 is a protein from the TGF-beta cytokine family of proteins and is sometimes referred to as TGFB-4.^[6]^[7] It is secreted and plays a role in left-right asymmetry determination of organ systems during development. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs.

Lefty2 is also sometimes referred to as Endometrial Bleeding-Associated Factor (EBAF).^[6] Some types of infertility have been associated with dysregulated expression of this gene in the endometrium and the protein may play a role in endometrial bleeding.

Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143768 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066652 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Left-right determination factor 2". Retrieved 2016-04-19.
^ ^a ^b GeneCards Human Gene Database. "LEFTY2 Gene - GeneCards | LFTY2 Protein | LFTY2 Antibody". www.genecards.org. Archived from the original on 2021-12-15. Retrieved 2025-04-03.
^ "LEFTY2 left-right determination factor 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2025-04-03.

Function

References

Further reading