Receptor modulator
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A receptor modulator, or receptor ligand, is a general term for a substance, endogenous or exogenous, that binds to and regulates the activity of chemical receptors. They are ligands that can act on different parts of receptors and regulate activity in a positive, negative, or neutral direction with varying degrees of efficacy. Categories of these modulators include receptor agonists and receptor antagonists, as well as receptor partial agonists, inverse agonists, orthosteric modulators, and allosteric modulators[1]. Examples of receptor modulators in modern medicine include CFTR modulators[2], selective androgen receptor modulators (SARMs), and muscarinic ACh receptor modulators.
See also
References
- ^ Westen, Gerard J. P. van; Gaulton, Anna; Overington, John P. (2014-04-03). "Chemical, Target, and Bioactive Properties of Allosteric Modulation". PLOS Computational Biology. 10 (4): e1003559. doi:10.1371/journal.pcbi.1003559. ISSN 1553-7358. PMC 3974644. PMID 24699297.
{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link) - ^ Bethesda, Cystic Fibrosis Foundation 4550 Montgomery Ave Suite 1100 N.; Md 20814301-951-4422 800-344-4823. "CFTR Modulator Therapies". www.cff.org. Retrieved 2020-12-08.
{{cite web}}: CS1 maint: numeric names: authors list (link)
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