SDK2

SDK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WF5, 1WFN, 1WFO, 1WIS
Identifiers
Aliases	SDK2, sidekick cell adhesion molecule 2
External IDs	OMIM: 607217; MGI: 2443847; HomoloGene: 10406; GeneCards: SDK2; OMA:SDK2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.1 Start 73,334,384 bp End 73,644,445 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 113,667,200 bp End 113,957,872 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue tibia tendon of biceps brachii germinal epithelium caput epididymis buccal mucosa cell retinal pigment epithelium mucosa of paranasal sinus entorhinal cortex lactiferous duct Top expressed in calvaria Rostral migratory stream sciatic nerve ciliary body medial dorsal nucleus prefrontal cortex fossa condyle molar arcuate nucleus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 54549 237979 Ensembl ENSG00000069188 ENSMUSG00000041592 UniProt Q58EX2 Q6V4S5 RefSeq (mRNA) NM_001144952 NM_019064 NM_172800 RefSeq (protein) NP_001138424 NP_766388 Location (UCSC) Chr 17: 73.33 – 73.64 Mb Chr 11: 113.67 – 113.96 Mb PubMed search
Wikidata
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For the Japanese game, see Super Donkey Kong 2

Protein sidekick-2 is a protein that in humans is encoded by the SDK2 gene.

The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined.

Further reading

• Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature. 440 (7087): 1045–9. doi:10.1038/nature04689. PMC 2610434. PMID 16625196.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Nguyen DN, Liu Y, Litsky ML, Reinke R (1997). "The sidekick gene, a member of the immunoglobulin superfamily, is required for pattern formation in the Drosophila eye". Development. 124 (17): 3303–12. PMID 9310325.