GDB Human Genome Database
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The GDB Human Genome Database was a community curated collection of human genomic data. What set GDB apart from other biological databases was its use of leaders in human genetics to act as curators for the data. In order to ensure a high degree of quality, records within GDB were subjected to a process of peer-review, similar to a traditional publication. Due to the International collaboration which made up the human genome project, GDB received funding from numerous sources in both Europe and Asia.
History
In 1989 the Howard Hughes Medical Institute provided funding to establish a central repository for human genetic mapping data. This project ultimately resulted in the creation of the GDB Human Genome DataBase in September 1990.[1][2] It was a key database in the Human Genome Project.[3]
Established under the leadership of Peter Pearson and Dick Lucier,[4] GDB received financial support from the US Department of Energy and the National Institutes of Health.[1] Located at the Johns Hopkins University School of Medicine, GDB became a source of high quality mapping data which were made available both online as well as through numerous printed publications.[citation needed] The project was supported internationally by the EU, Japan, and other countries.
The GDB had several directors in its time. Peter Pearson, David T. Kingsbury, Stantley Letovsky, Peter Li, and A. Jamie Cuticchia.
In 1998, the change of focus in the human genome project redirected US Department of Energy funds which were previously available for GDB.[5] However that same year, A. Jamie Cuticchia obtained funding from Canadian public and private sources to continue the operations of GDB. While the data curation continued to be performed at Johns Hopkins, GDB central operations were moved to The Hospital for Sick Children (HSC) in Toronto, Ontario, Canada.[6] In November 2001, the HSC fired Cuticchia due to a dispute over the GDB website domain name.[5]
In 2003 RTI International became the new host for GDB where it continued to be maintained as a public resource for high quality genetic and genomic information.
On June 1, 2008 RTI International shut down GDB operations. The data continues to be unavailable, though some data has been imported into NCBI databases.
References
- ^ a b Cuticchia, A.Jamie; Fasman, Kenneth H.; Kingsbury, David T.; Robbins, Robert J.; Pearson, Peter L. (1993). "The GDB TM human genome data base anno 1993". Nucleic Acids Research. 21 (13): 3003–3006. doi:10.1093/nar/21.13.3003.
- ^ Cuticchia, A.J. (27 Dec 1999). "Future vision of the GDB human genome database". Human Mutation. 15 (1): 62–67. doi:0.1002/(SICI)1098-1004(200001)15:1<62::AID-HUMU13>3.0.CO;2-R. PMID 10612824.
{{cite journal}}: Check|doi=value (help) - ^ "Human Genome News, September-December 1995: 7(3-4):15". web.ornl.gov.
- ^ Pearson, P.L. (25 April 1991). "The genome data base (GDB)--a human gene mapping repository". Nucleic Acids Research. 19 (suppl): 2237–2239. doi:10.1093/nar/19.suppl.2237.
- ^ a b Bonetta, Laura (November 2001). "Sackings leave gene database floundering". Nature. 414 (6862): 384–384. doi:10.1038/35106703.
- ^ "Human Genome News Vol.10,No.1-2, February 1999". web.ornl.gov. Retrieved 3 September 2020.
- S I Letovsky; R W Cottingham; C J Porter; P W Li (Jan 1, 1998). "GDB: the Human Genome Database". Nucleic Acids Res. 26 (1): 94–99. doi:10.1093/nar/26.1.94. PMC 147203. PMID 9399808.
- Fasman KH, Letovsky SI, Li P, Cottingham RW, Kingsbury DT (Jan 1, 1997). "The GDB Human Genome Database Anno 1997". Nucleic Acids Res. 25 (1): 72–81. doi:10.1093/nar/25.1.72. PMC 146370. PMID 9016507.
- Fasman KH, Cuticchia AJ, Kingsbury DT (1994). "The GDB Human Genome Database Anno 1994". Nucleic Acids Res. 22 (17): 3462–3479. doi:10.1093/nar/22.17.3462. PMC 308303. PMID 7937047.
External links
- https://web.archive.org/web/19970605132915/http://www.gdb.org/ archived version of the GDB website (1997)