Mustard Database
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| Content | |
|---|---|
| Description | Contains AR determinants and curated AR genes identified from metagenomics |
| Data types captured | Antimicrobial resistance genes and AR Determinants |
| Organisms | Bacteria |
| Contact | |
| Primary citation | PMID 30478291 |
| Access | |
| Website | mgps |
| Download URL | Download |
| Miscellaneous | |
| Bookmarkable entities | yes |
Mustard is a database that tracks Antimicrobial Resistance Determinants (ARDs). The method by which it tracks ARDs is using their own method adapted from Protein Homology Modelling called Pairwise Comparative Modelling (PCM), which increase specificity protein prediction, especially for distantly related protein homologues[1]. Using PCM, 6095 ARDs from 20 families in the human gut microbiota. Antibiotic resistance databases used were Resfinder[2], ARG-ANNOT[3], the now defunct Lahey Clinic, RED-DB, Marilyn Roberts website for tetracycline and macrolide resistance genes and metagenomics[4][5][6].
References
- ^ Ehrlich, S. Dusko; Kennedy, Sean P.; Doré, Joël; Haimet, Florence; Weiszer, Kevin; Levenez, Florence; Letur, Aline; Léjard, Véronique; Léonard, Pierre (2019-01). "Prediction of the intestinal resistome by a three-dimensional structure-based method". Nature Microbiology. 4 (1): 112–123. doi:10.1038/s41564-018-0292-6. ISSN 2058-5276.
{{cite journal}}: Check date values in:|date=(help) - ^ Zankari, E.; Hasman, H.; Cosentino, S.; Vestergaard, M.; Rasmussen, S.; Lund, O.; Aarestrup, F. M.; Larsen, M. V. (2012-07-10). "Identification of acquired antimicrobial resistance genes". Journal of Antimicrobial Chemotherapy. 67 (11): 2640–2644. doi:10.1093/jac/dks261. ISSN 0305-7453.
- ^ Gupta, Sushim Kumar; Padmanabhan, Babu Roshan; Diene, Seydina M.; Lopez-Rojas, Rafael; Kempf, Marie; Landraud, Luce; Rolain, Jean-Marc (2013-10-21). "ARG-ANNOT, a New Bioinformatic Tool To Discover Antibiotic Resistance Genes in Bacterial Genomes". Antimicrobial Agents and Chemotherapy. 58 (1): 212–220. doi:10.1128/aac.01310-13. ISSN 0066-4804.
- ^ Allen, Heather K; Moe, Luke A; Rodbumrer, Jitsupang; Gaarder, Andra; Handelsman, Jo (2008-10-09). "Functional metagenomics reveals diverse β-lactamases in a remote Alaskan soil". The ISME Journal. 3 (2): 243–251. doi:10.1038/ismej.2008.86. ISSN 1751-7362.
- ^ Moore, Aimée M.; Patel, Sanket; Forsberg, Kevin J.; Wang, Bin; Bentley, Gayle; Razia, Yasmin; Qin, Xuan; Tarr, Phillip I.; Dantas, Gautam (2013-11-13). "Pediatric Fecal Microbiota Harbor Diverse and Novel Antibiotic Resistance Genes". PLoS ONE. 8 (11): e78822. doi:10.1371/journal.pone.0078822. ISSN 1932-6203.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Sommer, M. O. A.; Dantas, G.; Church, G. M. (2009-08-27). "Functional Characterization of the Antibiotic Resistance Reservoir in the Human Microflora". Science. 325 (5944): 1128–1131. doi:10.1126/science.1176950. ISSN 0036-8075.