Complement component 9

C9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5FMW
Identifiers
Aliases	C9, ARMD15, C9D, complement component 9, complement C9
External IDs	OMIM: 120940; MGI: 1098282; HomoloGene: 74406; GeneCards: C9; OMA:C9 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	39,371,324 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	6,528,232 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; testicle; ; gonad; ; buccal mucosa cell; ; human kidney; ; corpus epididymis; ; stromal cell of endometrium; ; right adrenal gland; ; right adrenal cortex; ; right coronary artery;
	Top expressed in
	left lobe of liver; ; gallbladder; ; olfactory epithelium; ; embryo; ; blastocyst; ; embryo; ; yolk sac; ; precursor cell; ; migratory enteric neural crest cell; ; thoracic diaphragm;
	More reference expression data
	n/a
Gene ontology
Molecular function	growth factor activity;
Cellular component	integral component of membrane; extracellular region; integral component of plasma membrane; extracellular exosome; blood microparticle; membrane; membrane attack complex; extracellular space; cytosol; plasma membrane; other organism cell membrane;
Biological process	cytolysis; regulation of complement activation; hemolysis by symbiont of host erythrocytes; complement activation, alternative pathway; immune response; complement activation, classical pathway; immune system process; innate immune response; cell killing; protein homooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	735
	12279
	ENSG00000113600
	ENSMUSG00000022149
	P02748
	P06683
	NM_001737
	NM_013485; NM_001368420; NM_001368421
	NP_001728
	NP_038513; NP_001355349; NP_001355350
	Wikidata
View/Edit Human	View/Edit Mouse

Complement component 9 (C9) is a MACPF protein involved in the complement system, which is part of the innate immune system.^[5] C9 is a member of the complement membrane attack complex (MAC) and induces pores on cell membranes, causing lysis. There are 10-16 molecules of C9 in a single membrane attack complex (MAC), along with one of each of the complement components C5b, C6, C7 and C8.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113600 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022149 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lint TF, Zeitz HJ, Gewurz H (November 1980). "Inherited deficiency of the ninth component of complement in man". J. Immunol. 125 (5): 2252–7. PMID 7430628.
^ Janeway, CA Jr; Travers P; Walport M; et al. (2001). "The complement system and innate immunity". Immunobiology: The Immune System in Health and Disease. New York: Garland Science. Retrieved 29 December 2017.

External links

Complement+9 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113600 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022149 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7430628-5] Lint TF, Zeitz HJ, Gewurz H (November 1980). "Inherited deficiency of the ninth component of complement in man". J. Immunol. 125 (5): 2252–7. PMID 7430628.

[Janeway_2001-6] Janeway, CA Jr; Travers P; Walport M; et al. (2001). "The complement system and innate immunity". Immunobiology: The Immune System in Health and Disease. New York: Garland Science. Retrieved 29 December 2017.

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