Special Programme on Human Reproduction
The Special Programme on Human Reproduction (HRP) was a World Health Organization (WHO) endeavor.[1][2][3]
It resulted in the following marketed combined injectable contraceptives:[2][3][4][5][6][7][8][9]
- Estradiol cypionate/medroxyprogesterone acetate (brand names Cyclofem, Lunelle; code name HRP-112)
- Estradiol valerate/norethisterone enanthate (brand name Mesigyna; code name HRP-102)
And in the following never-marketed progestogen injectable contraceptives:[1][4]
- Levonorgestrel butanoate (code name HRP-002)
- Levonorgestrel cyclobutylcarboxylate (code name HRP-001)
- Levonorgestrel cyclopropylcarboxylate (code name HRP-003)
See also
References
- ^ a b Benagiano, G., & Merialdi, M. (2011). Carl Djerassi and the World Health Organisation special programme of research in human reproduction. Journal für Reproduktionsmedizin und Endokrinologie-Journal of Reproductive Medicine and Endocrinology, 8(1), 10-13. http://www.kup.at/kup/pdf/10163.pdf
- ^ a b Toppozada MK (April 1994). "Existing once-a-month combined injectable contraceptives". Contraception. 49 (4): 293–301. doi:10.1016/0010-7824(94)90029-9. PMID 8013216.
- ^ a b Koetsawang S (1991). "The injectable contraceptive: present and future trends". Ann. N. Y. Acad. Sci. 626: 30–42. doi:10.1111/j.1749-6632.1991.tb37897.x. PMID 1829341.
- ^ a b Garza-Flores J, Hall PE, Perez-Palacios G (1991). "Long-acting hormonal contraceptives for women". J. Steroid Biochem. Mol. Biol. 40 (4–6): 697–704. doi:10.1016/0960-0760(91)90293-E. PMID 1958567.
- ^ Koetsawang S (April 1994). "Once-a-month injectable contraceptives: efficacy and reasons for discontinuation". Contraception. 49 (4): 387–98. doi:10.1016/0010-7824(94)90034-5. PMID 8013221.
- ^ Garza-Flores J (April 1994). "Pharmacokinetics of once-a-month injectable contraceptives". Contraception. 49 (4): 347–59. doi:10.1016/0010-7824(94)90032-9. PMID 8013219.
- ^ Fraser IS (April 1994). "Vaginal bleeding patterns in women using once-a-month injectable contraceptives". Contraception. 49 (4): 399–420. doi:10.1016/0010-7824(94)90035-3. PMID 8013222.
- ^ Hassan EO, el-Nahal N, el-Hussinie M (August 1999). "Once-a-month injectable contraceptives, Cyclofem and Mesigyna, in Egypt. Efficacy, causes of discontinuation, and side effects". Contraception. 60 (2): 87–92. doi:10.1016/S0010-7824(99)00064-5. PMID 10592855.
- ^ Giwa-Osagie OF (May 1994). "Metabolic effects of once-a-month combined injectable contraceptives. The World Health Organization Task Force on Long-Acting Systemic Agents for Fertility Regulation, Geneva, Switzerland". Contraception. 49 (5): 421–33. doi:10.1016/0010-7824(94)90001-9. PMID 8045129.