Fosdevirine

Fosdevirine
Clinical data
Other names	GSK2248761; GSK2248761A; IDX-12899; IDX-899
ATC code	None;
Identifiers
	IUPAC name 5-Chloro-3-[[3-[(E)-2-cyanoethenyl]-5-methylphenyl]-methoxyphosphoryl]-1H-indole-2-carboxamide;
CAS Number	1018450-26-4;
PubChem CID	44232529;
Chemical and physical data
Formula	C20H17ClN3O3P
Molar mass	413.80 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC(=CC(=C1)/C=C/C#N)[P@](=O)(C2=C(NC3=C2C=C(C=C3)Cl)C(=O)N)OC;
	InChI InChI=1S/C20H17ClN3O3P/c1-12-8-13(4-3-7-22)10-15(9-12)28(26,27-2)19-16-11-14(21)5-6-17(16)24-18(19)20(23)25/h3-6,8-11,24H,1-2H3,(H2,23,25)/b4-3+/t28-/m1/s1; Key:CGBYTKOSZYQOPV-ASSBYYIWSA-N;

Fosdevirine is an experimental antiviral agent of the non-nucleoside reverse transcriptase inhibitor class that was studied for potential use in the treatment of HIV-AIDS.^[1]^[2]

It was discovered by Idenix Pharmaceuticals and was being developed by GlaxoSmithKline and ViiV Healthcare, but it has now been discontinued^[3]^[4] due to unexpected side effects.^[5]

References

^ . PMID 26804933. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
^ "Fosdevirine". aidsinfo.nih.gov.
^ "Fosdevirine". Adis Insight. Highest Development Phases: Discontinued, HIV-1 infections
^ "Fosdevirine". MedKoo Biosciences. GSK2248761 is no longer in clinical development.
^ . doi:0.3851/IMP2689. {{cite journal}}: Check |doi= value (help); Cite journal requires |journal= (help); Missing or empty |title= (help)

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[1] . PMID 26804933. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)

[2] "Fosdevirine". aidsinfo.nih.gov.

[3] "Fosdevirine". Adis Insight. Highest Development Phases: Discontinued, HIV-1 infections

[4] "Fosdevirine". MedKoo Biosciences. GSK2248761 is no longer in clinical development.

[5] . doi:0.3851/IMP2689. {{cite journal}}: Check |doi= value (help); Cite journal requires |journal= (help); Missing or empty |title= (help)

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