SCF-complex

SCF-complex, or SCF ubiquitin ligase complex a ubiquitin ligase, is named after ,SKP1, cullin and F-box protein, the first three of its subunits to be identified in the complex.

The ligase catalyse the addition of ubiquitin to protein molecules which to be destructed.

A multi-protein complex catalyzing the ubiquitylation of proteins destined for proteasomal degradation. Protein substrates are recognized by an F-box protein and delivered to the E3 ligase through the bridging protein, Skp. Cullen is the major scaffold of the SCF, as dogma indicates its binding of Skp, the ring-finger catalytic protein (eg ROC1), and recruitment of E2.