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Miniature Inverted-repeat Transposable Elements

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Miniature Inverted-repeat Transposable Elements (MITEs) are a group of non-autonomous Class II transposable elements (DNA sequences). Being non-autonomous, MITEs cannot code for their own transposase. They exist within the genomes of animals, plants, fungi and bacteria.[1][2][3][4] MITEs are generally short (50 to 500 bp) elements with terminal inverted repeats (TIRs; 10–15 bp) and two flanking target site duplications (TSDs). Like other transposons, MITEs are inserted predominantly in gene-rich regions and this can be a reason that they affect gene expression and play important roles in accelerating eukaryotic evolution.[5][6] Their high copy number inspite of small sizes has been a topic of interest.

Origin of MITEs

A detailed study of MITEs reveals that MITE subfamilies have arisen from related autonomous elements from a single genome and these subfamilies constitute the MITE families. One type of autonomous element can give rise to one or more MITE families.[7]

Classification

Based on their relations in sequences of TIRs with known TE superfamilies, MITEs have been classified into certain families. For example, wTourist, Acrobat, Hearthealer are MITE families in some plant species are under the TE superfamily PIF/Harbinger. Stowaway is a MITE family in Pisum sativum L. with TSD TA in relation with Tc1/mariner TE superfamily. A group of MITEs known as CMITES related to Piggybac superfamily were found in certain coral species.[8]

While most of the MITEs are grouped, some of them are yet to be allotted their TE superfamilies. Such families include AtATE in Arabidopsis thaliana and ATon family found in Aedes aegypti. Besides this, many more MITE families are likely to be discovered.

MITEs in Plant Genomes

MITEs were first discovered in plants. Elements belonging to the CACTA, hAT, Mutator, PIF, and Tc1/Mariner superfamilies have been described.[9] Depending upon the similarity of their terminal inverted repeats and target site duplications, most of the MITEs in plant genomes are divided into two major groups: Tourist-like MITEs (derived from PIF)[10] and Stowaway-like MITEs (derived from Tc1/mariner).[11]Stowaway and Tourist elements differ remarkably in their sequences but they have been found to have significant structural similarities.

Stowaway elements possess target site specificity, have small size and conserved terminal inverted repeat. So is the case determined in Tourist like MITEs. They can form stable DNA secondary structures which can be very useful in identifying them. A few Stowaway elements also contain cis-acting regulatory domains.

Other MITE superfamilies have also been described in plants, such as hAT-type MITEs in banana[12] and the nightshades.[13]

MITEs as Genetic Markers

Based on the presence or absence of MITE family Heartbreaker (Hbr) in maize genome, a molecular marker was developed. These Hbr markers have been proved to be stable, uniformly distributed in maize genome. A study by Casa et al showed that HBr markers could be used along with other molecular markers to study genotype of related maize inbred lines[14]

Computational Assistance

Software like FINDMITE use sequence entries of some average sized bp to identify MITE families. A MATLAB-based progarm called detectMITE can detect MITEs on genome wide scale and was tested on rice genome.[15] Others like MUST and MITE-Hunter are also used for similar purposes. To characterize MITE families a toolkit has been developed called MITE Analysis Kit MAK by Yang and Hall.

References

  1. ^ Lu, C; Chen, J; Zhang, Y; Hu, Q; Su, W; Kuang, H (2013-03-25). "Miniature Inverted–Repeat Transposable Elements (MITEs) Have Been Accumulated through Amplification Bursts and Play Important Roles in Gene Expression and Species Diversity in Oryza sativa". Molecular Biology and Evolution. 29 (3): 1005–17. doi:10.1093/molbev/msr282. PMC 3278479. PMID 22096216.
  2. ^ Shirasawa, K; Hirakawa, H; Tabata, S; Hasegawa, M; Kiyoshima, H; Suzuki, S; Sasamoto, S; Watanabe, A; Fujishiro, T; Isobe, S (2013-03-25). "Characterization of active miniature inverted-repeat transposable elements in the peanut genome". Theoretical and Applied Genetics. 124 (8): 1429–38. doi:10.1007/s00122-012-1798-6. PMC 3336055. PMID 22294450.
  3. ^ Siguier, P; Filee, J; Chandler, M (2006). "Insertion sequences in prokaryotic genomes". Current Opinion in Microbiology. 9 (5): 526–531. doi:10.1016/j.mib.2006.08.005.
  4. ^ Bardaji, L; Añorga, M; Jackson, RW; Martínez-Bilbao, A; Yanguas, N; Murillo, J (2011). "Miniature transposable sequences are frequently mobilized in the bacterial plant pathogen Pseudomonas syringae pv. phaseolicola". PLOS One. 6 (10): e25773. Bibcode:2011PLoSO...625773B. doi:10.1371/journal.pone.0025773. PMC 3189936. PMID 22016774.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  5. ^ Zhang, Q.; Arbuckle, J.; Wessler, S. R. (2000). "Recent, extensive, and preferential insertion of members of the miniature inverted-repeat transposable element family Heartbreaker into genic regions of maize". Proceedings of the National Academy of Sciences. 97 (3): 1160–1165. Bibcode:2000PNAS...97.1160Z. doi:10.1073/pnas.97.3.1160.
  6. ^ Feschotte, C.; Jiang, N.; Wessler, S. R. (2002). "Plant transposable elements: where genetics meets genomics". Nature Reviews Genetics. 3 (5): 329–341. doi:10.1038/nrg793.
  7. ^ Feschotte, C., Zhang, X., and Wessler, S.R. 2002b. "Miniature inverted-repeat transposable elements (MITEs) and their relationship with established DNA transposons." In Mobile DNA II. Edited by N. Craig, R. Craigie, M. Gellert, and A. Lambowitz. American Society of Microbiology Press, Washington, D.C. pp. 1147–1158.
  8. ^ Wang, S.; Zhang, L.; Meyer, E.; Matz, M.V. (2010). "Characterization of a group of MITEs with unusual features from two coral genomes". PLOS One. 5 (5): e10700. Bibcode:2010PLoSO...510700W. doi:10.1371/journal.pone.0010700. PMC 2872659. PMID 20502527.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  9. ^ Feschotte, Cédric; Pritham, Ellen J. (2007). "DNA Transposons and the Evolution of Eukaryotic Genomes". Annual review of genetics. 41: 331–368. doi:10.1146/annurev.genet.40.110405.090448. ISSN 0066-4197. PMC 2167627. PMID 18076328.{{cite journal}}: CS1 maint: PMC format (link)
  10. ^ Zhang, Xiaoyu; Jiang, Ning; Feschotte, Cédric; Wessler, Susan R (2004-2). "PIF- and Pong-like transposable elements: distribution, evolution and relationship with Tourist-like miniature inverted-repeat transposable elements". Genetics. 166 (2): 971–986. ISSN 0016-6731. PMC 1470744. PMID 15020481. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link)
  11. ^ Thomas E., Bureau; Wessler, S. (1994). "Stowaway: A New Family of Inverted Repeat Elements Associated with the Genes of Both Monocotyledonous and Dicotyledonous Plants". The Plant Cell. 6 (6): 907. doi:10.2307/3869968. JSTOR 3869968. PMC 160488. PMID 8061524. {{cite journal}}: |first1= has generic name (help)
  12. ^ Menzel, Gerhard; Heitkam, Tony; Seibt, Kathrin M.; Nouroz, Faisal; Müller-Stoermer, Manuela; Heslop-Harrison, John S.; Schmidt, Thomas (2014-12-01). "The diversification and activity of hAT transposons in Musa genomes". Chromosome Research. 22 (4): 559–571. doi:10.1007/s10577-014-9445-5. ISSN 0967-3849.
  13. ^ Kuang, Hanhui; Padmanabhan, Chellappan; Li, Feng; Kamei, Ayako; Bhaskar, Pudota B.; Ouyang, Shu; Jiang, Jiming; Buell, C. Robin; Baker, Barbara (2009-01-01). "Identification of miniature inverted-repeat transposable elements (MITEs) and biogenesis of their siRNAs in the Solanaceae: New functional implications for MITEs". Genome Research. 19 (1): 42–56. doi:10.1101/gr.078196.108. ISSN 1088-9051. PMID 19037014.
  14. ^ Casa, A. M. (2002). "Evaluation of Hbr (MITE) markers for assessment of genetic relationships among maize (Zea mays L.) inbred lines". Theor. Appl. Genet. 104 (1): 104–110. doi:10.1007/s001220200012. PMID 12579434.
  15. ^ Ye, Congting; Ji, Guoli; Liang, Chun (22 January 2016). "detectMITE: A novel approach to detect miniature inverted repeat transposable elements in genomes". Scientific Reports. 6 (1): 19688. Bibcode:2016NatSR...619688Y. doi:10.1038/srep19688. PMC 4726161. PMID 26795595.
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