Complement component 7
| complement component 7 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | C7 | ||||||
| NCBI gene | 730 | ||||||
| HGNC | 1346 | ||||||
| OMIM | 217070 | ||||||
| RefSeq | NM_000587 | ||||||
| UniProt | P10643 | ||||||
| Other data | |||||||
| Locus | Chr. 5 p13 | ||||||
| |||||||
Complement component 7 is a protein involved in the complement system of the innate immune system. C7 is part of the membrane attack complex (MAC) which creates a hole on pathogen surfaces, leading to cell lysis and death.
Its primary task is to bind the C5bC6 complex together. This junction alters the configuration of the protein molecules, exposing a hydrophobic site on C7 that allows the C7 to insert into the phospholipid bilayer of the pathogen.
See also
External links
- Complement+C7 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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