Active chromatin sequence

An active chromatin sequence (ACS) is a region of DNA in a eukaryotic chromosome in which histone modifications such as acetylation lead to exposure of the DNA sequence thus allowing binding of transcription factors and transcription to take place. Active chromatin may also be called euchromatin. ACSs may occur in non-expressed gene regions which are assumed to be "poised" for transcription. The sequence once exposed often contains a promoter to began transcription. At this site acetylation or methylation can take place causing a conformational change to the chromatin. At the active chromatin sequence site deacetylation can caused the gene to be repressed in not being expressed.

See also

Chromatin

References

1. Sabo PJ, Humbert R, Hawrylycz M, et al. (March 2004). "Genome-wide identification of DNaseI hypersensitive sites using active chromatin sequence libraries". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4537–42. doi:10.1073/pnas.0400678101. PMC 384782. PMID 15070753.