"HistoneDB 2.0 – with variants" is a comprehensive database of histone protein sequences including histone variants, classified by histone types and variants maintained by National Center for Biotechnology Information. Entries in the database include sequence and structural annotations with many interactive tools to explore and compare sequences of different variants from various organisms. The core of the database is a manually curated set of histone sequences grouped into 30 different variant subsets with variant-specific annotations. The curated set is supplemented by an automatically extracted set of histone sequences from the non-redundant protein database using algorithms trained on the curated set. The interactive web site supports various searching strategies in both datasets: browsing of phylogenetic trees; on-demand generation of multiple sequence alignments with feature annotations; classification of histone-like sequences and browsing of the taxonomic diversity for every histone variant. HistoneDB 2.0 is a resource for the interactive comparative analysis of histone protein sequences and their implications for chromatin function.
History of the database
HistoneDB 2.0 is the successor of the earlier versions of the Histone database that was available starting from mid-1990.[2][3][4][5][6][7][8][9]
References
^Draizen EJ, Shaytan AK, Marino-Ramirez L, Talbert PB, Landsman D, Panchenko AR (2016). "HistoneDB 2.0: a histone database with variants--an integrated resource to explore histones and their variants". Database : the journal of biological databases and curation. doi:10.1093/database/baw014. PMID26989147.
^Marino-Ramirez L, Levine KM, Morales M, Zhang S, Moreland RT, Baxevanis AD, Landsman D (2011). "The Histone Database: an integrated resource for histones and histone fold-containing proteins". Database : the journal of biological databases and curation. doi:10.1093/database/bar048. PMID22025671.
^Marino-Ramirez L, Hsu B, Baxevanis AD, Landsman D. (2006). "The Histone Database: a comprehensive resource for histones and histone fold-containing proteins". Proteins. doi:10.1002/prot.20814. PMID16345076. {{cite journal}}: Vancouver style error: punctuation in name 4 (help)
^Sullivan S, Sink DW, Trout KL, Makalowska I, Taylor PM, Baxevanis AD, Landsman D (2002). "The Histone Database". Nucleic Acids Res. PMID11752331.
^Sullivan SA, Aravind L, Makalowska I, Baxevanis AD, Landsman D (2000). "The histone
database: a comprehensive WWW resource for histones and histone fold-containing proteins". Nucleic Acids Res. PMID10592260. {{cite journal}}: line feed character in |title= at position 12 (help)
^Makalowska I, Ferlanti ES, Baxevanis AD, Landsman D (1999). "Histone Sequence
Database: sequences, structures, post-translational modifications and genetic loci". Nucleic Acids Res. PMID9847217. {{cite journal}}: line feed character in |title= at position 17 (help)
^Baxevanis AD, Landsman D (1998). "Histone Sequence Database: new histone fold family members". Nucleic Acids Res. PMID9399877.
^Baxevanis AD, Landsman D (1997). "Histone and histone fold sequences and structures: a database". Nucleic Acids Res. PMID9016552.
^Baxevanis AD, Landsman D (1996). "Histone Sequence Database: a compilation of highly-conserved nucleoprotein sequences". Nucleic Acids Res. PMID8594591.
This article has not been added to any content categories. Please help out by adding categories to it so that it can be listed with similar articles. (January 2017)
