Histone Database
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| Content | |
|---|---|
| Description | curated database of histone proteins and their variants |
| Contact | |
| Research center | National Center for Biotechnology Information |
| Primary citation | Draizen EJ, Shaytan AK, Marino-Ramirez L, Talbert PB, Landsman D, Panchenko AR (2016)[1] |
| Access | |
| Website | https://www.ncbi.nlm.nih.gov/projects/HistoneDB2.0 |
"HistoneDB 2.0 – with variants" is a comprehensive database of histone protein sequences including histone variants, classified by histone types and variants maintained by National Center for Biotechnology Information.[1] Entries in the database include sequence and structural annotations with many interactive tools to explore and compare sequences of different variants from various organisms. The core of the database is a manually curated set of histone sequences grouped into 30 different variant subsets with variant-specific annotations. The curated set is supplemented by an automatically extracted set of histone sequences from the non-redundant protein database using algorithms trained on the curated set. The interactive web site supports various searching strategies in both datasets: browsing of phylogenetic trees; on-demand generation of multiple sequence alignments with feature annotations; classification of histone-like sequences and browsing of the taxonomic diversity for every histone variant. HistoneDB 2.0 is a resource for the interactive comparative analysis of histone protein sequences and their implications for chromatin function.
- ^ a b Draizen EJ, Shaytan AK, Marino-Ramirez L, Talbert PB, Landsman D, Panchenko AR (2016). "HistoneDB 2.0: a histone database with variants--an integrated resource to explore histones and their variants". Database : the journal of biological databases and curation. doi:10.1093/database/baw014. PMID 26989147.