Multisynthetase complex auxiliary component p38

AIMP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DPG, 4YCU, 4YCW, 5A34, 5A1N, 5A5H
Identifiers
Aliases	AIMP2, JTV-1, JTV1, P38, PRO0992, Multisynthetase complex auxiliary component p38, aminoacyl tRNA synthetase complex interacting multifunctional protein 2, HLD17
External IDs	OMIM: 600859; MGI: 2385237; HomoloGene: 4594; GeneCards: AIMP2; OMA:AIMP2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	6,023,834 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	143,846,665 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; tibialis anterior muscle; ; vastus lateralis muscle; ; deltoid muscle; ; body of tongue; ; muscle of arm; ; biceps brachii; ; gastrocnemius muscle; ; triceps brachii muscle;
	Top expressed in
	triceps brachii muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; gastrocnemius muscle; ; extensor digitorum longus muscle; ; plantaris muscle; ; temporal muscle; ; medial head of gastrocnemius muscle; ; tibialis anterior muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; molecular adaptor activity;
Cellular component	cytoplasm; membrane; nucleus; cytosol; aminoacyl-tRNA synthetase multienzyme complex;
Biological process	multicellular organism development; cell differentiation; type II pneumocyte differentiation; positive regulation of neuron death; positive regulation of protein ubiquitination; tRNA aminoacylation for protein translation; protein biosynthesis; negative regulation of cell population proliferation; apoptotic process; positive regulation of aminoacyl-tRNA ligase activity; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	7965
	231872
	ENSG00000106305
	ENSMUSG00000029610
	Q13155
	Q8R010
NM_006303; NM_001326606; NM_001326607; NM_001326609; NM_001326611;
	NM_018570; NM_001326610; NM_001362785; NM_001362787
	NM_001172146; NM_146165
NP_001313535; NP_001313536; NP_001313538; NP_001313539; NP_001313540;
	NP_006294; NP_001349714; NP_001349716
	NP_001165617; NP_666277
	Wikidata
View/Edit Human	View/Edit Mouse

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 is an enzyme that in humans is encoded by the AIMP2 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

Multisynthetase complex auxiliary component p38 has been shown to interact with Parkin (ligase),^[8] P53^[6] and KARS.^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106305 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029610 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nicolaides NC, Kinzler KW, Vogelstein B (August 1996). "Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene". Genomics. 29 (2): 329–34. doi:10.1006/geno.1995.9997. PMID 8666379.
^ ^a ^b Han JM, Park BJ, Park SG, Oh YS, Choi SJ, Lee SW, Hwang SK, Chang SH, Cho MH, Kim S (August 2008). "AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53". Proc Natl Acad Sci U S A. 105 (32): 11206–11. doi:10.1073/pnas.0800297105. PMC 2516205. PMID 18695251.
^ "Entrez Gene: JTV1 JTV1 gene".
^ Corti, Olga; Hampe Cornelia; Koutnikova Hana; Darios Frédéric; Jacquier Sandrine; Prigent Annick; Robinson Jean-Charles; Pradier Laurent; Ruberg Merle; Mirande Marc; Hirsch Etienne; Rooney Thomas; Fournier Alain; Brice Alexis (June 2003). "The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration". Hum. Mol. Genet. 12 (12). England: 1427–37. doi:10.1093/hmg/ddg159. ISSN 0964-6906. PMID 12783850. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)
^ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). England: 1173–8. doi:10.1038/nature04209. PMID 16189514. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laysummary=, and |laydate= (help)
^ Quevillon, S; Robinson J C; Berthonneau E; Siatecka M; Mirande M (January 1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein". J. Mol. Biol. 285 (1). ENGLAND: 183–95. doi:10.1006/jmbi.1998.2316. ISSN 0022-2836. PMID 9878398. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading