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Transcription factor binding site databases

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Identification of genomic regulatory elements is essential for understanding the dynamics of cellular processes. Recent advances in chromatin immunoprecipitation followed by sequencing (ChIP-seq) have provided powerful ways to identify genome-wide profiling of DNA-binding proteins and histone modifications[1][2]. The application of ChIP-seq methods has reliably discovered transcription factor binding sites and histone modification sites.

Transcription factor binding site databases

Comprehensive List of transcription factor binding sites (TFBSs) databases based on ChIP-seq data as follows:

Name Description type Link References
ChIPBase ChIPBase a database for transcription factor binding sites, motifs (~1290 transcrition factors) and decoding the transcriptional regulation of lncRNAs, miRNAs and protein-coding genes from ~10,200 curated peak datasets derived from ChIP-seq methods in 10 species database [website [3]
ChEA transcription factor regulation inferred from integrating genome-wide ChIP-X experiments. database website [4]
CistromeMap a knowledgebase and web server for ChIP-Seq and DNase-Seq studies in mouse and human. database website [5]
CTCFBSDB a database for CTCF binding sites and genome organization database website [6]
Factorbook a Wiki-based database for transcription factor-binding data generated by the ENCODE consortium. database website [7]
hmChIP a database and web server for exploring publicly available human and mouse ChIP-seq and ChIP-chip data. database website [8]
HOCOMOCO a comprehensive collection of human transcription factor binding sites models. database website [9]
JASPAR The JASPAR CORE database contains a curated, non-redundant set of profiles, derived from published collections of experimentally defined transcription factor binding sites for eukaryotes. database [website [10]
SwissRegulon a database of genome-wide annotations of regulatory sites. database [website [11]
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  1. ^ Park, Peter J. (1 October 2009). "ChIP–seq: advantages and challenges of a maturing technology". Nature Reviews Genetics. 10 (10): 669–680. doi:10.1038/nrg2641. ISSN 1471-0056. PMID 19736561.
  2. ^ Farnham, Peggy J. (1 September 2009). "Insights from genomic profiling of transcription factors". Nature Reviews Genetics. 10 (9): 605–616. doi:10.1038/nrg2636. ISSN 1471-0056. PMID 19668247.
  3. ^ Yang, Jian-Hua; Li, Jun-Hao; Jiang, Shan; Zhou, Hui; Qu, Liang-Hu (1 January 2013). "ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data". Nucleic Acids Research. 41 (Database issue): D177–187. doi:10.1093/nar/gks1060. ISSN 1362-4962.
  4. ^ Lachmann, Alexander; Xu, Huilei; Krishnan, Jayanth; Berger, Seth I.; Mazloom, Amin R.; Ma'ayan, Avi (1 October 2010). "ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments". Bioinformatics (Oxford, England). 26 (19): 2438–2444. doi:10.1093/bioinformatics/btq466. ISSN 1367-4811. PMID 20709693.
  5. ^ Qin, Bo; Zhou, Meng; Ge, Ying; Taing, Len; Liu, Tao; Wang, Qian; Wang, Su; Chen, Junsheng; Shen, Lingling; Duan, Xikun; Hu, Sheng'en; Li, Wei; Long, Henry; Zhang, Yong; Liu, X. Shirley (15 May 2012). "CistromeMap: a knowledgebase and web server for ChIP-Seq and DNase-Seq studies in mouse and human". Bioinformatics (Oxford, England). 28 (10): 1411–1412. doi:10.1093/bioinformatics/bts157. ISSN 1367-4811.
  6. ^ . PMID 23193294. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  7. ^ . PMID 23203885. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  8. ^ . PMID 21450710. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  9. ^ . PMID 26586801. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  10. ^ . PMID 26531826. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  11. ^ . PMID 23180783. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
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