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Scriptaid

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Scriptaid
Clinical data
ATC code
  • none
Identifiers
  • 6-(1,3-Dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H18N2O4
Molar mass326.347 g/mol g·mol−1
3D model (JSmol)
  • C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCCC(=O)NO

Scriptaid is a drug which acts as a histone deacetylase inhibitor, and was one of the first compounds discovered via high-throughput screening that acts at this target.[1] Scriptaid itself was never developed for medical applications, but led to the development of structurally related drugs such as vorinostat which have been accepted into clinical use. Most early research using these compounds focused on their anti-cancer activity,[2] but more recent research has found scriptaid to be useful in other applications such as cloning and research into regulation of metabolism.[3][4][5][6]

References

  1. ^ . PMID 10866300. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  2. ^ . PMID 15642405. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  3. ^ . PMID 23132328. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  4. ^ . PMID 26559066. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  5. ^ . PMID 27281695. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  6. ^ . PMID 27626651. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)