Scriptaid

Scriptaid
Clinical data
ATC code	none;
Identifiers
	IUPAC name 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide;
CAS Number	287383-59-9 ;
PubChem CID	5186;
CompTox Dashboard (EPA)	DTXSID70274458 ;
Chemical and physical data
Formula	C18H18N2O4
Molar mass	326.347 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCCC(=O)NO;

Scriptaid is a drug which acts as a histone deacetylase inhibitor, and was one of the first compounds discovered that acts at this target via high-throughput screening.^[1] Scriptaid itself was never developed for medical applications, but led to the development of structurally related drugs such as vorinostat which have been accepted into clinical use. Most early research using these compounds focused on their anti-cancer activity,^[2] but more recent research has found scriptaid to be useful in other applications such as cloning and research into regulation of metabolism.^[3]^[4]^[5]

References

^ Su GH, Sohn TA, Ryu B, Kern SE. A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. Cancer Res. 2000 Jun 15;60(12):3137-42. PMID 10866300
^ Monneret C. Histone deacetylase inhibitors. Eur J Med Chem. 2005 Jan;40(1):1-13. PMID 15642405
^ Zhu X, Nie J, Quan S, Xu H, Yang X, Lu Y, Lu K, Lu S. In vitro production of cloned and transgenically cloned embryos from Guangxi Huanjiang Xiang pig. In Vitro Cell Dev Biol Anim. 2016 Feb;52(2):137-43. doi: 10.1007/s11626-015-9957-0. PMID 26559066
^ Rissi VB, Glanzner WG, Mujica LK, Antoniazzi AQ, Gonçalves PB, Bordignon V. Effect of Cell Cycle Interactions and Inhibition of Histone Deacetylases on Development of Porcine Embryos Produced by Nuclear Transfer. Cell Reprogram. 2016 Feb;18(1):8-16. doi: 10.1089/cell.2015.0052. PMID 27281695
^ Gaur V, Connor T, Sanigorski A, Martin SD, Bruce CR, Henstridge DC, Bond ST, McEwen KA, Kerr-Bayles L, Ashton TD, Fleming C, Wu M, Pike Winer LS, Chen D, Hudson GM, Schwabe JW, Baar K, Febbraio MA, Gregorevic P, Pfeffer FM, Walder KR, Hargreaves M, McGee SL. Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation. Cell Rep. 2016 Sep 13;16(11):2802-10. doi: 10.1016/j.celrep.2016.08.005. PMID 27626651

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[1] Su GH, Sohn TA, Ryu B, Kern SE. A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. Cancer Res. 2000 Jun 15;60(12):3137-42. PMID 10866300

[2] Monneret C. Histone deacetylase inhibitors. Eur J Med Chem. 2005 Jan;40(1):1-13. PMID 15642405

[3] Zhu X, Nie J, Quan S, Xu H, Yang X, Lu Y, Lu K, Lu S. In vitro production of cloned and transgenically cloned embryos from Guangxi Huanjiang Xiang pig. In Vitro Cell Dev Biol Anim. 2016 Feb;52(2):137-43. doi: 10.1007/s11626-015-9957-0. PMID 26559066

[4] Rissi VB, Glanzner WG, Mujica LK, Antoniazzi AQ, Gonçalves PB, Bordignon V. Effect of Cell Cycle Interactions and Inhibition of Histone Deacetylases on Development of Porcine Embryos Produced by Nuclear Transfer. Cell Reprogram. 2016 Feb;18(1):8-16. doi: 10.1089/cell.2015.0052. PMID 27281695

[5] Gaur V, Connor T, Sanigorski A, Martin SD, Bruce CR, Henstridge DC, Bond ST, McEwen KA, Kerr-Bayles L, Ashton TD, Fleming C, Wu M, Pike Winer LS, Chen D, Hudson GM, Schwabe JW, Baar K, Febbraio MA, Gregorevic P, Pfeffer FM, Walder KR, Hargreaves M, McGee SL. Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation. Cell Rep. 2016 Sep 13;16(11):2802-10. doi: 10.1016/j.celrep.2016.08.005. PMID 27626651

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