Signal transducing adaptor molecule

STAM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L0A, 3F1I, 3LDZ
Identifiers
Aliases	STAM, STAM-1, STAM1, Signal transducing adaptor molecule
External IDs	OMIM: 601899; MGI: 1329014; HomoloGene: 37788; GeneCards: STAM; OMA:STAM - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	17,716,824 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	14,154,445 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; amniotic fluid; ; endothelial cell; ; retinal pigment epithelium; ; corpus callosum; ; Brodmann area 23; ; pars compacta; ; germinal epithelium; ; Pons; ; ganglionic eminence;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ganglionic eminence; ; perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; superior frontal gyrus; ; medial ganglionic eminence; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin-like protein ligase binding;
Cellular component	cytoplasm; cytosol; endosome; early endosome membrane; membrane; ESCRT-0 complex;
Biological process	negative regulation of epidermal growth factor receptor signaling pathway; regulation of extracellular exosome assembly; multivesicular body assembly; endosomal transport; protein transport; positive regulation of exosomal secretion; intracellular protein transport; signal transduction; positive regulation of signal transduction; macroautophagy; protein deubiquitination; membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	8027
	20844
	ENSG00000136738
	ENSMUSG00000026718
	Q92783
	P70297
NM_003473; NM_001324282; NM_001324283; NM_001324284; NM_001324285;
	NM_001324286; NM_001324287; NM_001324288; NM_001324289
	NM_011484; NM_001356337
NP_001311211; NP_001311212; NP_001311213; NP_001311214; NP_001311215;
	NP_001311216; NP_001311217; NP_001311218; NP_003464
	NP_035614; NP_001343266
	Wikidata
View/Edit Human	View/Edit Mouse

Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene.^[5]^[6]

Template:PBB Summary

Interactions

Signal transducing adaptor molecule has been shown to interact with STAMBP,^[7]^[8] HGS,^[9]^[10]^[11] TIMM8A^[12] and Janus kinase 2.^[13]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136738 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026718 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K (October 1996). "Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM". Biochem Biophys Res Commun. 225 (3): 1035–9. doi:10.1006/bbrc.1996.1290. PMID 8780729.
^ "Entrez Gene: STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1".
^ Kato M, Miyazawa K, Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". J. Biol. Chem. 275 (48). UNITED STATES: 37481–7. doi:10.1074/jbc.M007251200. ISSN 0021-9258. PMID 10982817. {{cite journal}}: Cite has empty unknown parameters: |1=, |laysource=, |laydate=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Tanaka N, Kaneko K, Asao H, Kasai H, Endo Y, Fujita T, Takeshita T, Sugamura K (July 1999). "Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines". J. Biol. Chem. 274 (27). UNITED STATES: 19129–35. doi:10.1074/jbc.274.27.19129. ISSN 0021-9258. PMID 10383417. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). England: 1173–8. doi:10.1038/nature04209. PMID 16189514. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help)
^ Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K (December 1997). "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth". J. Biol. Chem. 272 (52). UNITED STATES: 32785–91. doi:10.1074/jbc.272.52.32785. ISSN 0021-9258. PMID 9407053. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Bache KG, Raiborg C, Mehlum A, Stenmark H (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". J. Biol. Chem. 278 (14). United States: 12513–21. doi:10.1074/jbc.M210843200. ISSN 0021-9258. PMID 12551915. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Blackstone C, Roberts RG, Seeburg DP, Sheng M (May 2003). "Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1". Biochem. Biophys. Res. Commun. 305 (2). United States: 345–52. doi:10.1016/S0006-291X(03)00767-8. ISSN 0006-291X. PMID 12745081. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help)
^ Takeshita T, Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N, Murata K, Ishii N, Sugamura K (April 1997). "STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction". Immunity. 6 (4). UNITED STATES: 449–57. doi:10.1016/S1074-7613(00)80288-5. ISSN 1074-7613. PMID 9133424. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help)

Interactions

References

Further reading