User:Vivek sai chinnu/sandbox
Yellapragada subbaraw | |
|---|---|
| Born | 1895 january 12 |
| Died | 1948 august8 |
| Cause of death | heart disease |
| Nationality | indian |
| Alma mater | harvard medical school madras medical college |
Yellapragada Subbarow was an indian biochemist who discovered the functions of adenosine triphosphate as a energy source in the cell,and developedmethotrexatefor the treatment of cancer.most of his career was spent in us. Subbarow was also credited with the synthesis of chemical compounds folic acidand methotrexate.
A fungus genus was named subbaromyces in his honor.You've probably never heard of DR.Yellapragada subbarow. Yet because he lived you may be alive and are well today.Because he lived ypu may live longer.
Early life and Education
He was born in Bhimavaram,madras presidency ,now in west godavaridistrict Andhrapradeshin india.he passed through a traumatic period in his schooling at Rajahmundry. he passed the intermediate examination from the presidency collage and entered the madras medical collage where his education was supported by his friends and kasturi suryanarayana murthy,whose daughter he later married.
subbarow tried to enter the madras medical service with out success.he then took up the job as lecturer in anatomy at Dr.lakshmipathi's ayurvedic collage.he was fascinated by the healing power of ayurvedic medicines and began to engage in research to put ayurvedic on moern footing.The promise of support from Malladi sathyalingam,naicker charitiesin Kakinada,and financial assistance raised by his father in law,enabled subbarow to proceed to us. he arrived in Boston on26 oct 1922.
career in united states
after earning a diploma from the Harvard medical schoolhe joined harvard as a junior faculty member with Cyrus fiske he developed a method for estamination of phosphorusin body fluids and tissues.He discovered the role of Phosphoceratine and Adenosine triphosphatein muscular activity, which earned him a entry in to biochemistryin 1930. he obtained his PHD in same year.He joined Lederle laboratories,a division of American cynamid,after he was denied a regular faculty person at havard.
At lederle he developed a method to synthesize Folic acid,vitamib9, based on wor by Lucky willsto isolate folic acid as a protective agent against Anemia.after his work on folic acid and with considerable input from DR.Sidney farber,he developed the important anti cancer drugMethotrexateone of the first cancerChemotherapy agents. subbarow also discovered Hetrazanwhich was used by the world health organisationagainst Filariasis.under subbarow [[Benjamin duggar made his discovery of the worlds first Tetracycline,Aureomycinin 1945.
publications
Angier, R.B.; Boothe, J.H.; Hutchings, B.L.; Mowat, J.H.; Semb, J.; Stokstad, E.L.R.; SubbaRow, Y.; Waller, C.W.; Cosulich, D.B.; Fahrenbach, M.J.; Hultquist, M.E.; Kuh, E.; Northey, E.H.; Seeger, D.R.; Sickels, J.P.; Smith Jr, J.M. (1945). "Synthesis of a compound identical with the L. casei factor isolated from liver". Science 102 (2644): 227–228. doi:10.1126/science.102.2644.227. PMID 17778509. Angier, R.B.; Mowat, J.H.; Boothe, J.H.; Waller, C.W.; Semb, J.; Hutchings, B.L.; Stokstad, E.L.R.; Subbarow, Y. (1948). "The preparation of 2-amino-4-hydroxy-6-keto-5,5-dichlorodihydropyrimidine". Journal of the American Chemical Society 70 (3): 1274–1275. doi:10.1021/ja01183a502. Angier, R.B.; Stokstad, E.L.R.; Mowat, J.H.; Hutchings, B.L.; Boothe, J.H.; Waller, C.W.; Semb, J.; SubbaRow, Y.; Cosulich, D.B.; Fahrenbach, M.J.; Hultquist, M.E.; Kuh, E.; Northey, E.H.; Seeger, D.R.; Sickels, J.P.; Smith Jr, J.M. (1948). "Synthesis of pteroylglutamic acid. III". Journal of the American Chemical Society 70 (1): 25–26. doi:10.1021/ja01181a008. Angier, R.B.; Waller, C.W.; Boothe, J.H.; Mowat, J.H.; Semb, J.; Hutchings, B.L.; Stokstad, E.L.R.; Subbarow, Y. (1948). "Pteridine chemistry. I". Journal of the American Chemical Society 70 (9): 3029–3031. doi:10.1021/ja01189a058. Angier, R.B.; Waller, C.W.;Hutchings, B.L.;Boothe, J.H.;Mowat, J.H.;Semb, J.;SubbaRow , Y. (1950). "Pteroic acid derivatives. VI. Unequivocal syntheses of some isomeric glutamic acid peptides". Journal of the American Chemical Society 72 (1): 74–77. doi:10.1021/ja01157a021. Baker, B.R.; Querry, M.V.; Bernstein, S.; Safir, S.R.; Subbarow, Y. (1947). "Biotin. IV. A second synthesis of 2-(Œ¥-carboxybutyl)-thiophane-3,4-dicarboxylic acid". Journal of Organic Chemistry 12 (1): 167–173. doi:10.1021/jo01165a021. Baker, B.R.; Querry, M.V.; McEwen, W.L.; Bernstein, S.; Safir, S.R.; Dorfman, L.; Subbarow, Y. (1947). "Biotin. VI. Synthesis of biotin and epiallobiotin". Journal of Organic Chemistry 12 (1): 186–198. doi:10.1021/jo01165a023. Bernstein, S.; Binovi, L.J.; Dorfman, L.; Sax, K.J.; Subbarow, Y. (1949). "7-Dehydrocholesterol". Journal of Organic Chemistry 14 (3): 433–446. doi:10.1021/jo01155a015. Bernstein, S.; Sax, K.J.; Subbarow, Y. (1948). "7-Dehydrocholesteryl chloride and bromide". Journal of Organic Chemistry 13 (6): 837–842. doi:10.1021/jo01164a009. Boothe, J.H.; Mowat, J.H.; Hutchings, B.L.; Angier, R.B.; Waller, C.W.; Stokstad, E.L.R.; Semb, J.; Gazzola, A.L.; Subbarow, Y. (1948). "Pteroic acid derivatives. II. Pteroyl-γ-glutamylglutamic acid and pteroyl-γ-glutamyl-γ-glutamylglutamic acid". Journal of the American Chemical Society 70 (3): 1099–1102. doi:10.1021/ja01183a068. Boothe, J.H.; Semb, J.; Waller, C.W.; Angier, R.B.; Mowat, J.H.; Hutchings, B.L.; Stokstad, E.L.R.; Subbarow, Y. (1949). "Pteroic acid derivatives. III. Pteroyl-γ-glutamylglutamic acid and pteroyl-γ-glutamyl-γ-glutamylglutamic acid". Journal of the American Chemical Society 71 (7): 2304–2308. doi:10.1021/ja01175a010. Boothe, J.H.; Waller, C.W.;Stokstad, E.L.R.; Hutchings, B.L.; Mowat, J.H.; Angier, R.B.; Semb, J.; SubbaRow, Y.; Cosulich, D.B.; Fahrenbach, M.J.; Hultquist, M.E.; Kuh, E.; Northey, E.H.; Seeger, D.R.; Sickels, J.P.; Smith Jr, J.M. (1948). "Synthesis of pteroylglutamic acid. IV". Journal of the American Chemical Society 70 (1): 27–28. doi:10.1021/ja01181a009. Fiske, C.H.; Subbarow, Y. (1927). "The nature of the "inorganic phosphate" in voluntary muscle". Science 65 (1686): 399. doi:10.1126/science.65.1686.401. PMID 17807679. Fiske, C.H.; Subbarow, Y. (1929). "Phosphorus compounds of muscle and liver". Science 70 (1816): 381–382. doi:10.1126/science.70.1816.381-a. Harned, B.K.; Cunningham, R.W.; Halliday, S.; Vessey, R.E.; Yuda, N.N.; Clark, M.C.; Hine, C.H.; Cosgrove, R.; Subbarow, Y. (1948). "Studies on the chemotherapy of filariasis.
References
Mukherjee, Siddhartha (16 November 2010). The Emperor of All Maladies: A Biography of Cancer. Simon and Schuster. p. 31. ISBN 978-1-4391-0795-9. Retrieved 6 September 2011. Quote: "Any one of these achievements should have been enough to guarantee him a professorship at Harvard. But Subbarow was a foreigner, a reclusive, nocturnal, heavily accented vegetarian who lived in a one-room apartment downtown, befriended only by other nocturnal recluses" Pushpa Mitra Bhargava (2001). "History of Medicine: Dr. Yellapragada SubbaRow (1895-1948) - He Transformed Science; Changed Lives" (PDF). Journal of the Indian Academy of Clinical Medicine 2 (1,2): 96_100. Yellapragada SubbaRow Archives OnLine The Hindu : Discoverer of miracle medicines - Y. Subba Row (1895-1948) MycoBank, retrieved 26 December 2015 Hesseltine, C.W. (1953), "Study of Trickling Filter Fungi", Bulletin of the Torrey Botanical Club 80 (6): 507–514, doi:10.2307/2481965, JSTOR 2481965 page 511 "Miracle man of miracle drugs: Dr Yellapragada SubbaRow". Retrieved 10 March 2014. Dr. Yellapragada SubbaRow (1895-1948): The man and the method by Kapur, S. & Gupta, S. P. K. in Indian Journal of Experimental Biology, 36(11):1087-92 Farber, S; Cutler, EC; Hawkins, JW; Harrison, JH; Peirce Ec, 2nd; Lenz, GG (1947). "The Action of Pteroylglutamic Conjugates on Man". Science 106 (2764): 619–21. doi:10.1126/science.106.2764.619. PMID 17831847. Farber et al.'s article, published in the New England Journal of Medicine in 1946, noted Dr Subbarow's work as a foundation for this landmark paper. The paper remains one of the earliest top-cited research articles and is a classic in the field of medicine. Farber, Sidney; Farber S; Diamond LK; Mercer RD; et al. (1948). "Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin)". N. Engl. J. Med. 238 (23): 787–93. doi:10.1056/NEJM194806032382301. PMID 18860765. Miller, DR (2006). "A tribute to Sidney Farber-- the father of modern chemotherapy". British journal of haematology 134 (1): 20–6. doi:10.1111/j.1365-2141.2006.06119.x. PMID 16803563. WHO Report on Global Filaria Control 2002