T-cell receptor excision circles

T-cell receptor excision circles (TRECs) are small circles of DNA created in T-cells during their passage through the thymus as they rearrange their TCR genes.^[1] Their presence indicates maturation of T cells; TRECs are reduced in SCID (Severe combined immunodeficiency disease).

Signal joint T-cell receptor excision circles (sjTRECs) were in the news as a way to test the age of the individual from a blood sample.^[2] The detection of sjTRECs can be further used as a diagnostic tool to monitor the thymic output (e.g., following hematopoietic stem cell transplantation or in cases of AIDS).^[3]

References

^ http://allergycases.org/2010/05/t-cell-receptor-excision-circles-trecs.html^{[full citation needed]}
^ telegraph.co.uk^{[full citation needed]}
^ Al-Harthi L, Marchetti G, Steffens CM, Poulin J, Sékaly R, Landay A (2000). "Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA)". Journal of Immunological Methods. 237 (1–2): 187–97. doi:10.1016/S0022-1759(00)00136-8. PMID 10725462.

This genetics article is a stub. You can help Wikipedia by expanding it.

[1] ttp://allergycases.org/2010/05/t-cell-receptor-excision-circles-trecs.html^{[full citation needed]}

[2] telegraph.co.uk^{[full citation needed]}

[3] Al-Harthi L, Marchetti G, Steffens CM, Poulin J, Sékaly R, Landay A (2000). "Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA)". Journal of Immunological Methods. 237 (1–2): 187–97. doi:10.1016/S0022-1759(00)00136-8. PMID 10725462.

[1]

[2]

[3]

See also

References