Signal transducing adaptor molecule

STAM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L0A, 3F1I, 3LDZ
Identifiers
Aliases	STAM, STAM-1, STAM1, Signal transducing adaptor molecule
External IDs	OMIM: 601899; MGI: 1329014; HomoloGene: 37788; GeneCards: STAM; OMA:STAM - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	17,716,824 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	14,154,445 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; amniotic fluid; ; endothelial cell; ; retinal pigment epithelium; ; corpus callosum; ; Brodmann area 23; ; pars compacta; ; germinal epithelium; ; Pons; ; ganglionic eminence;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ganglionic eminence; ; perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; superior frontal gyrus; ; medial ganglionic eminence; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin-like protein ligase binding;
Cellular component	cytoplasm; cytosol; endosome; early endosome membrane; membrane; ESCRT-0 complex;
Biological process	negative regulation of epidermal growth factor receptor signaling pathway; regulation of extracellular exosome assembly; multivesicular body assembly; endosomal transport; protein transport; positive regulation of exosomal secretion; intracellular protein transport; signal transduction; positive regulation of signal transduction; macroautophagy; protein deubiquitination; membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	8027
	20844
	ENSG00000136738
	ENSMUSG00000026718
	Q92783
	P70297
NM_003473; NM_001324282; NM_001324283; NM_001324284; NM_001324285;
	NM_001324286; NM_001324287; NM_001324288; NM_001324289
	NM_011484; NM_001356337
NP_001311211; NP_001311212; NP_001311213; NP_001311214; NP_001311215;
	NP_001311216; NP_001311217; NP_001311218; NP_003464
	NP_035614; NP_001343266
	Wikidata
View/Edit Human	View/Edit Mouse

Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene.^[5]^[6]

Template:PBB Summary

Interactions

Signal transducing adaptor molecule has been shown to interact with STAMBP,^[7]^[8] HGS,^[9]^[10]^[11] TIMM8A^[12] and Janus kinase 2.^[13]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136738 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026718 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K (October 1996). "Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM". Biochem Biophys Res Commun. 225 (3): 1035–9. doi:10.1006/bbrc.1996.1290. PMID 8780729.
^ "Entrez Gene: STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1".
^ Kato, M; Miyazawa K; Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". J. Biol. Chem. 275 (48). UNITED STATES: 37481–7. doi:10.1074/jbc.M007251200. ISSN 0021-9258. PMID 10982817. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)CS1 maint: unflagged free DOI (link)
^ Tanaka, N; Kaneko K; Asao H; Kasai H; Endo Y; Fujita T; Takeshita T; Sugamura K (July 1999). "Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines". J. Biol. Chem. 274 (27). UNITED STATES: 19129–35. doi:10.1074/jbc.274.27.19129. ISSN 0021-9258. PMID 10383417. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Rual, Jean-François (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). England: 1173–8. doi:10.1038/nature04209. PMID 16189514. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
^ Asao, H; Sasaki Y; Arita T; Tanaka N; Endo K; Kasai H; Takeshita T; Endo Y; Fujita T; Sugamura K (December 1997). "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth". J. Biol. Chem. 272 (52). UNITED STATES: 32785–91. doi:10.1074/jbc.272.52.32785. ISSN 0021-9258. PMID 9407053. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Bache, Kristi G; Raiborg Camilla; Mehlum Anja; Stenmark Harald (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". J. Biol. Chem. 278 (14). United States: 12513–21. doi:10.1074/jbc.M210843200. ISSN 0021-9258. PMID 12551915. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Blackstone, Craig; Roberts Roland G; Seeburg Daniel P; Sheng Morgan (May 2003). "Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1". Biochem. Biophys. Res. Commun. 305 (2). United States: 345–52. doi:10.1016/S0006-291X(03)00767-8. ISSN 0006-291X. PMID 12745081. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Takeshita, T; Arita T; Higuchi M; Asao H; Endo K; Kuroda H; Tanaka N; Murata K; Ishii N; Sugamura K (April 1997). "STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction". Immunity. 6 (4). UNITED STATES: 449–57. doi:10.1016/S1074-7613(00)80288-5. ISSN 1074-7613. PMID 9133424. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading