Amylmetacresol

Amylmetacresol

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	R02AA20 (WHO)
Legal status
Legal status	OTC
Identifiers
IUPAC name 5-methyl-2-pentylphenol
CAS Number	53043-14-4
PubChem CID	14759
ChemSpider	14076 Y
ChEMBL	ChEMBL1512677
CompTox Dashboard (EPA)	DTXSID8046791
ECHA InfoCard	100.013.722
Chemical and physical data
Formula	C12H18O
Molar mass	178.27 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCC1=C(C=C(C=C1)C)O
InChI InChI=1S/C12H18O/c1-3-4-5-6-11-8-7-10(2)9-12(11)13/h7-9,13H,3-6H2,1-2H3 Y Key:CKGWFZQGEQJZIL-UHFFFAOYSA-N Y
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Amylmetacresol (AMC) is an antiseptic used to treat infections of the mouth and throat. It is used as an active pharmaceutical ingredient in Strepsils, Cēpacol, Gorpils and Lorsept throat lozenges.

Chemically, AMC is derivative of m-cresol, with a pentyl group attached to the sixth carbon atom. The pure substance melts at 24°C, and boils between 137 to 139°C (at 6.7 kPa). It is soluble in water, ethanol, acetone, ether, and oil. AMC exhibits low toxicity, and a RW coefficient of 250.

See also

• 2,4-Dichlorobenzyl alcohol
• Hexylresorcinol
• Cetylpyridinium chloride
• Dequalinium

External links

• C. E. Coulthard (1931). "The Disinfectant and Antiseptic Properties of Amyl-meta-cresol". J Exp Patho. 12 (5): 331–336. Retrieved 29 November 2015.
• Oxford JS, Lambkin R, Gibb I, Balasingam S, Chan C, Catchpole A (2005). "A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV". Antivir Chem Chemother. 16 (2): 129–34. Retrieved 29 November 2015.
• McNally D, Shephard A, Field E (2012). "Randomised, double-blind, placebo-controlled study of a single dose of an amylmetacresol/2,4-dichlorobenzyl alcohol plus lidocaine lozenge or a hexylresorcinol lozenge for the treatment of acute sore throat due to upper respiratory tract infection". J Pharm Pharm Sci. 15 (2): 281–94. Retrieved 29 November 2015.