Unspecific peroxygenase
| Unspecific peroxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.11.2.1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Unspecific peroxygenase (EC 1.11.2.1, aromatic peroxygenase, mushroom peroxygenase, haloperoxidase-peroxygenase, Agrocybe aegerita peroxidase) is an enzyme with systematic name substrate:hydrogen peroxide oxidoreductase (RH-hydroxylating or -epoxidising).[1][2][3][4][5][6][7][8][9] This enzyme catalyses the following chemical reaction
- RH + H2O2 ROH + H2O
Unspecific peroxygenase is a heme-thiolate protein comparable to Cytochrome_P450 in the ability to catalyze a variety of P450 reactions (hence "unspecific"), but forms a unique, solely fungal, protein family of extracellular enzymes.
References
- ^ Ullrich, R.; Nuske, J.; Scheibner, K.; Spantzel, J.; Hofrichter, M. (2004). "Novel haloperoxidase from the agaric basidiomycete Agrocybe aegerita oxidizes aryl alcohols and aldehydes". Appl. Environ. Microbiol. 70 (8): 4575–4581. doi:10.1128/AEM.70.8.4575-4581.2004. PMC 492325. PMID 15294788.
- ^ Ullrich, R.; Hofrichter, M. (2005). "The haloperoxidase of the agaric fungus Agrocybe aegerita hydroxylates toluene and naphthalene". FEBS Lett. 579 (27): 6247–6250. doi:10.1016/j.febslet.2005.10.014. PMID 16253244.
- ^ Anh, D.H.; Ullrich, R.; Benndorf, D.; Svatos, A.; Muck, A.; Hofrichter, M. (2007). "The coprophilous mushroom Coprinus radians secretes a haloperoxidase that catalyzes aromatic peroxygenation". Appl. Environ. Microbiol. 73 (17): 5477–5485. doi:10.1128/AEM.00026-07. PMC 2042081. PMID 17601809.
- ^ Ullrich, R.; Dolge, C.; Kluge, M.; Hofrichter, M. (2008). "Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita". FEBS Lett. 582 (29): 4100–4106. doi:10.1016/j.febslet.2008.11.006. PMID 19022254.
- ^ Aranda, E.; Kinne, M.; Kluge, M.; Ullrich, R.; Hofrichter, M. (2009). "Conversion of dibenzothiophene by the mushrooms Agrocybe aegerita and Coprinellus radians and their extracellular peroxygenases". Appl. Microbiol. Biotechnol. 82 (6): 1057–1066. doi:10.1007/s00253-008-1778-6. PMID 19039585.
- ^ Kinne, M.; Poraj-Kobielska, M.; Aranda, E.; Ullrich, R.; Hammel, K.E.; Scheibner, K.; Hofrichter, M. (2009). "Regioselective preparation of 5-hydroxypropranolol and 4′-hydroxydiclofenac with a fungal peroxygenase". Bioorg. Med. Chem. Lett. 19 (11): 3085–3087. doi:10.1016/j.bmcl.2009.04.015. PMID 19394224.
- ^ Kluge, M.; Ullrich, R.; Dolge, C.; Scheibner, K.; Hofrichter, M. (2009). "Hydroxylation of naphthalene by aromatic peroxygenase from Agrocybe aegerita proceeds via oxygen transfer from H2O2 and intermediary epoxidation". Appl. Microbiol. Biotechnol. 81 (6): 1071–1076. doi:10.1007/s00253-008-1704-y. PMID 18815784.
- ^ Kinne, M.; Poraj-Kobielska, M.; Ralph, S.A.; Ullrich, R.; Hofrichter, M.; Hammel, K.E. (2009). "Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenase". J. Biol. Chem. 284: 29343–29349. doi:10.1074/jbc.M109.040857. PMC 2785565. PMID 19713216.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Pecyna, M.J.; Ullrich, R.; Bittner, B.; Clemens, A.; Scheibner, K.; Schubert, R.; Hofrichter, M. (2009). "Molecular characterization of aromatic peroxygenase from Agrocybe aegerita". Appl. Microbiol. Biotechnol. 84 (5): 885–897. doi:10.1007/s00253-009-2000-1. PMID 19434406.