CSPG4

CSPG4
Identifiers
Aliases	CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2, chondroitin sulfate proteoglycan 4, CSPG4A
External IDs	OMIM: 601172; MGI: 2153093; HomoloGene: 20445; GeneCards: CSPG4; OMA:CSPG4 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	75,712,848 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	56,807,154 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; cartilage tissue; ; tibia; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; Descending thoracic aorta; ; ascending aorta; ; left coronary artery; ; muscle layer of sigmoid colon;
	Top expressed in
	ascending aorta; ; tunica media of zone of aorta; ; internal carotid artery; ; aortic valve; ; fossa; ; condyle; ; external carotid artery; ; phalanx of foot; ; phalanx of third toe; ; phalanx of fourth toe;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; protein kinase binding;
Cellular component	integral component of membrane; cell projection; membrane; focal adhesion; plasma membrane; integral component of plasma membrane; extracellular region; cell surface; lysosomal lumen; apical plasma membrane; Golgi lumen; extracellular exosome; lamellipodium membrane; extracellular matrix; collagen-containing extracellular matrix;
Biological process	glycosaminoglycan metabolic process; cell differentiation; intracellular signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; chondroitin sulfate biosynthetic process; multicellular organism development; angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; chondroitin sulfate catabolic process; dermatan sulfate biosynthetic process; cell population proliferation; tissue remodeling; signal transduction; glial cell migration;
	Sources:Amigo / QuickGO
Orthologs
	1464
	121021
	ENSG00000173546
	ENSMUSG00000032911
	Q6UVK1
	Q8VHY0
	NM_001897
	NM_139001
	NP_001888
	NP_620570
	Wikidata
View/Edit Human	View/Edit Mouse

Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene.^[5]^[6]^[7]

CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173546 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032911 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA (Oct 1996). "Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan". Proc Natl Acad Sci U S A. 93 (18): 9710–5. doi:10.1073/pnas.93.18.9710. PMC 38494. PMID 8790396.
^ Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S (May 2006). "Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells". Oncogene. 25 (20): 2873–84. doi:10.1038/sj.onc.1209319. PMID 16407841.
^ ^a ^b "Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4".

Kirschfink M, Blase L, Engelmann S, Schwartz-Albiez R (1997). "Secreted chondroitin sulfate proteoglycan of human B cell lines binds to the complement protein C1q and inhibits complex formation of C1". J. Immunol. 158 (3): 1324–31. PMID 9013976.
Iida J, Meijne AM, Oegema TR, et al. (1998). "A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion". J. Biol. Chem. 273 (10): 5955–62. doi:10.1074/jbc.273.10.5955. PMID 9488735.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Eisenmann KM, McCarthy JB, Simpson MA, et al. (2000). "Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas". Nat. Cell Biol. 1 (8): 507–13. doi:10.1038/70302. PMID 10587647.
Barritt DS, Pearn MT, Zisch AH, et al. (2000). "The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2". J. Cell. Biochem. 79 (2): 213–24. doi:10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G. PMC 3501957. PMID 10967549.
Iida J, Pei D, Kang T, et al. (2001). "Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen". J. Biol. Chem. 276 (22): 18786–94. doi:10.1074/jbc.M010053200. PMID 11278606.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Staub E, Hinzmann B, Rosenthal A (2002). "A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family". FEBS Lett. 527 (1–3): 114–8. doi:10.1016/S0014-5793(02)03195-2. PMID 12220645.
Stegmüller J, Werner H, Nave KA, Trotter J (2003). "The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling". J. Biol. Chem. 278 (6): 3590–8. doi:10.1074/jbc.M210010200. PMID 12458226.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Legg J, Jensen UB, Broad S, et al. (2004). "Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis". Development. 130 (24): 6049–63. doi:10.1242/dev.00837. PMID 14573520.
Ghali L, Wong ST, Tidman N, et al. (2004). "Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein". J. Invest. Dermatol. 122 (2): 433–42. doi:10.1046/j.0022-202X.2004.22207.x. PMID 15009727.
Fukushi J, Makagiansar IT, Stallcup WB (2005). "NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin". Mol. Biol. Cell. 15 (8): 3580–90. doi:10.1091/mbc.E04-03-0236. PMC 491820. PMID 15181153.
Yang J, Price MA, Neudauer CL, et al. (2004). "Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms". J. Cell Biol. 165 (6): 881–91. doi:10.1083/jcb.200403174. PMC 2172406. PMID 15210734.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Makagiansar IT, Williams S, Dahlin-Huppe K, et al. (2005). "Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility". J. Biol. Chem. 279 (53): 55262–70. doi:10.1074/jbc.M411045200. PMID 15504744.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Petrini S, Tessa A, Stallcup WB, et al. (2006). "Altered expression of the MCSP/NG2 chondroitin sulfate proteoglycan in collagen VI deficiency". Mol. Cell. Neurosci. 30 (3): 408–17. doi:10.1016/j.mcn.2005.08.005. PMID 16169245.
Brekke C, Lundervold A, Enger PØ, et al. (2006). "NG2 expression regulates vascular morphology and function in human brain tumours". NeuroImage. 29 (3): 965–76. doi:10.1016/j.neuroimage.2005.08.026. PMID 16253523.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173546 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032911 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8790396-5] Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA (Oct 1996). "Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan". Proc Natl Acad Sci U S A. 93 (18): 9710–5. doi:10.1073/pnas.93.18.9710. PMC 38494. PMID 8790396.

[pmid16407841-6] Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S (May 2006). "Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells". Oncogene. 25 (20): 2873–84. doi:10.1038/sj.onc.1209319. PMID 16407841.

[entrez-7] "Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4".

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CSPG4

See also

References

Further reading