GSTM2

GSTM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HNA, 1HNB, 1HNC, 1XW5, 1YKC, 2AB6, 2C4J, 2GTU, 3GTU, 3GUR
Identifiers
Aliases	GSTM2, GST4, GSTM, GSTM2-2, GTHMUS, glutathione S-transferase mu 2 (muscle), glutathione S-transferase mu 2
External IDs	OMIM: 138380; MGI: 1915562; HomoloGene: 41816; GeneCards: GSTM2; OMA:GSTM2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	109,709,551 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	107,839,133 bp
RNA expression pattern
	Top expressed in
	left ovary; ; right uterine tube; ; right ovary; ; fundus; ; pituitary gland; ; tibial nerve; ; vagina; ; anterior pituitary; ; prostate; ; muscle layer of sigmoid colon;
	Top expressed in
	efferent ductule; ; interventricular septum; ; left lobe of liver; ; lumbar subsegment of spinal cord; ; Gonadal ridge; ; lens; ; right ventricle; ; ganglionic eminence; ; testicle; ; adrenal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein homodimerization activity; glutathione binding; protein binding; enzyme binding; signaling receptor binding; glutathione peroxidase activity; glutathione transferase activity;
Cellular component	cytoplasm; cytosol; sarcoplasmic reticulum; extracellular exosome; intercellular bridge;
Biological process	xenobiotic catabolic process; glutathione metabolic process; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; negative regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of ryanodine-sensitive calcium-release channel activity; cellular detoxification of nitrogen compound; nitrobenzene metabolic process; cellular response to caffeine; metabolism; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; relaxation of cardiac muscle; glutathione derivative biosynthetic process; regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion; cellular oxidant detoxification; linoleic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2946
	68312
	ENSG00000213366
	ENSMUSG00000004035
	P28161
	Q80W21
	NM_001142368; NM_000848
	NM_026672; NM_001356351
	NP_000839; NP_001135840
	NP_080948; NP_001343280
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione S-transferase Mu 2 is an enzyme that in humans is encoded by the GSTM2 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213366 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004035 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vorachek WR, Pearson WR, Rule GS (Jun 1991). "Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus". Proc Natl Acad Sci U S A. 88 (10): 4443–7. doi:10.1073/pnas.88.10.4443. PMC 51676. PMID 2034681.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Campbell E, Takahashi Y, Abramovitz M, Peretz M, Listowsky I (Jul 1990). "A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes". J Biol Chem. 265 (16): 9188–93. PMID 2345169.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ "Entrez Gene: GSTM2 glutathione S-transferase M2 (muscle)".

References

Further reading