Multiple inert gas elimination technique
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The multiple inert gas elimination technique (or MIGET) is a technique used mainly in pulmonology, that involves measuring the concentrations of various infused, inert gases in mixed venous blood, arterial blood, and expired gas of a subject. The technique quantifies true shunt, physiological dead space ventilation, ventilation versus blood flow (VA/Q) ratios, and diffusion limitation.
Background
Hypoxemia is generally attributed to one of four processes: hypoventilation, shunt (right to left), diffusion limitation, and ventilation/perfusion (VA/Q) inequality.[1] Moreover, there are also "extrapulmonary" factors that can contribute to fluctuations in arterial PO2.
There are several measures of hypoxemia that can be assessed, but there are various limitations associated with each. It was for this reason that the MIGET was developed, to overcome the shortcomings of previous methods.[2] [3] [4] [5]
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- ^ West, JB (2008). Pulmonary Pathophysiology - The Essentials. Baltimore, MD: Lippincott Williams & Wilkins.
- ^ Wagner, PD; Saltzman, HA; West, JB (1974). "Measurement of continuous distributions of ventilation-perfusion ratios: theory". J Appl Physiol. 36: 588–599.
- ^ Wagner, PD; Naumann, PF; Laravuso, RB (1974). "Simulatenous measurement of eight foreign gases in blood by gas chromatography". J Appl Physiol. 36: 600–605.
- ^ Wagner, PD; Laravuso, RB; Uhl, RR; West, JB (1974). "Continuous distributions of ventilation-perfusion ratios in normal subjects breathing air and 100% O2". J Clin Invest. 54: 54–68.
- ^ Evans, JW; Wagner, PD (1977). "Limits on VA/Q distributions from analysis or experimental inert gas elimination". J Appl Physiol. 42: 889–898.