PH partition theory
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pH partition is the tendency for acids to accumulate in basic fluid compartments, and bases to accumulate in acidic compartments. The reason for this phenomenon is that acids become negatively electric charged in basic fluids, since they donate a proton. On the other hand, bases become positively electric charged in acid fluids, since they receive a proton. Since electric charge decrease the membrane permeability of substances, once an acid enters a basic fluid and becomes electrically charged, then it cannot escape that compartment with ease and therefore accumulates, and vice versa with bases.
'''drug pKa and gastrointestinal pH:'''
the amount of drugs that exists in unionized form is a function of dissociation constant pKa of the drug and pH of the fluid at the absorption site.
it can be determined by henderson-hasselbach equations for weak acids and weak bases.
pH= pKa+ log = unionized drug concentration ÷ ionized drug concentration
written by- mr. Ronak soni, geetanjali institute of pharmacy, udaipur , rajasthan, india.
email id- rssoni1998@gmail.com
contact no. - 7062738407
See also
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