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Community Programs for Clinical Research on AIDS

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The Community Programs for Clinical Research on AIDS (CPCRA) was a programme sponsored by National Institutes of Health (NIH) in the United States.[1][2]

History

The CPCRA was established in 1989[3] and included 15 research units. A Statistical Center at the University of Minnesota was funded from 1990 to 1997.[4][5]

The CPCRA was one of four networks that NIH was using to conduct clinical trials that were looking to understand possible therapies for people with HIV infection.[6] Th CPCRA network was community-based with access to diverse populations across the spectrum of HIV diseases..."[7]

The overall objective of the CPCRA is to design studies of sufficient size and duration of follow up to evaluate the long-term benefits and unintended consequences of various treatment strategies using available agents to assess long-term immunologic, virologic and clinical outcomes. CPCRA trials are designed with nested substudies aimed at understanding the pathogenesis of HIV infection and the public health implications of its treatment.[8]

The International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) biorepository system has its roots in the CPCRA.[9]

An antiretroviral medication self-reporting questionnaire was developed by the programme.[10]

The programme organised the 058 FIRST (Flexible Initial Retrovirus Suppressive Therapies) trial: a large, long-term, randomized, prospective comparison of three different antiretroviral strategies in highly active antiretroviral therapy-naïve, HIV-1-infected persons.[11]

References

  1. ^ [1]
  2. ^ Cox, LE; Rouff, JR; Svendsen, KH; Markowitz, M; Abrams, DI (November 1998). "Community advisory boards: their role in AIDS clinical trials. Terry Beirn Community Programs for Clinical Research on AIDS" (PDF). Health Soc Work. 23 (4): 290–7.
  3. ^ "An inventory of federally sponsored HIV and HIV-relevant databases. Database:Terry Beirn community programs for clinical research on AIDS (CPCRA) observational database (ODB)". Assistant Secretary for Planning and Evaluation (ASPE). 7 January 2000. Retrieved 21 April 2016.
  4. ^ research grant information
  5. ^ [2]
  6. ^ "NIAID Research on AIDS" (Press release). aidsinfo.nih.gov. 1 January 1995. Retrieved 22 April 2016.
  7. ^ [3]
  8. ^ [4][dead link]
  9. ^ Huppler Hullsiek, Katherine; George, Michelle; Brown, Shawn K. (November 2010). "Designing and managing a flexible and dynamic biorepository system: a 15 year perspective from the CPCRA, ESPRIT, and INSIGHT clinical trial networks". Curr Opin HIV AIDS. 5 (6): 538–544. doi:10.1097/COH.0b013e32833f2058.
  10. ^ Mannheimer, Sharon; Friedland, Gerald; Matts, John; Child, Carroll; Chesney, Margaret (2002). "The Consistency of Adherence to Antiretroviral Therapy Predicts Biologic Outcomes for Human Immunodeficiency Virus—Infected Persons in Clinical Trials". Clinical Infectious Diseases. 34: 1115–21. doi:10.1086/339074.
  11. ^ MacArthur, RD; Chen, L; Mayers, DL; Besch, CL; Novak, R; van den Berg-Wolf, M; Yurik, T; Peng, G; Schmetter, B; Brizz, B; Abrams, D (April 2001). "The rationale and design of the CPCRA (Terry Beirn Community Programs for Clinical Research on AIDS) 058 FIRST (Flexible Initial Retrovirus Suppressive Therapies) trial". Control Clin Trials. 22: 176−90. doi:10.1016/S0197-2456(01)00111-8.


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