Oncomodulin
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Oncomodulin is a parvalbumin-family calcium-binding protein expressed and secreted by macrophages[1].
To date, it has been found in the central nervous system in inner ear hair cells and retinal ganglion cells. Oncomodulin promotes axon regeneration in retinal ganglion cells [1] and maintains functioning in mouse cochlear hair cells[2].
Protein Structure
Oncomodulin is highly conserved across vertebrate evolution (NCBI database). It is a smaller calcium-binding protein (11.7-kDa) which resembles the EF-hand domain of calmodulin (32% sequence identity), alpha-parvalbumin (54%), S100-beta (34%), and calbindin (25%) and resembles alpha-parvalbumin in its N-terminal region (52%). It has a 40-residue N-terminal domain with an inactive calcium binding site and a 70-residue EF-hand domain with one low affinity Ca2+ and Mg2+ binding site and one high-affinity Ca2+ site [1].
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- ^ a b c Yin; et al. (June 2006). "Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells". Nature Neuroscience. 9 (6): 843–852. doi:10.1038/nn1701.
{{cite journal}}:|access-date=requires|url=(help); Explicit use of et al. in:|last1=(help) - ^ Tong; et al. (February 2016). "Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice". Journal of Neuroscience. 36 (5). doi:10.1523/JNEUROSCI.3311-15.2016.
{{cite journal}}:|access-date=requires|url=(help); Explicit use of et al. in:|last1=(help)