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SCP-ISM, or Screened Coulomb Potentials Implicit Solvent Model is a continuum approximation of solvent effects for use in computer simulations of biologicalmacromolecules, such as proteins and nucleic acids, usually within the framework of molecular dynamics. It is based on the classic theory of polar liquids, as developed by Peter Debye and corrected by Lars Onsager to incorporate reaction field effects. The model can be combined with quantum chemical calculations to formally derive a continuum model of solvent effects suitable for computer simulations of small and large molecular systems.
