Reliability theory of aging and longevity

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The reliability theory of aging is an attempt to apply the principles of reliability theory to human biology. The theory was published in Russian by Leonid A. Gavrilov and Natalia S. Gavrilova as Biologiia prodolzhitelʹnosti zhizni in 1986, and in English translation as The Biology of Life Span: A Quantitative Approach in 1991.^[1]^[2]

The hypothesis is based on the unusual premise that humans are born in a highly defective state. According to the model, this is then made worse by environmental and mutational damage; redundancy allows the organism to survive for a while.^[3]

References

^ Leonid A. Gavrilov, Natalia S. Gavrilova; V.P. Skulachev (ed.); John and Liliya Payne (trans.) (1991). The Biology of Life Span: A Quantitative Approach. Chur; New York: Harwood Academic Publishers. ISBN 9783718649839.
^ A.J.S. Rayl (May 2002). Aging, in Theory: A Personal Pursuit. Do body system redundancies hold the key? The Scientist 16 (10): 20.
^ [s.n.] (1 September 2004). Engineering and Aging: The Best Is Yet to Be. IEEE Spectrum. Archived 23 April 2014.

v t e Senescence (biology of ageing)
Senescence	Antagonistic pleiotropy hypothesis Catabiosis DNA damage theory of aging Evolution of ageing Free-radical theory of aging Hayflick limit Immunosenescence Negligible senescence Network theory of aging Plant senescence Programmed cell death Reliability theory of aging and longevity Selection shadow Stem cell theory of aging
Related topics	Adaptive mutation Ageing Biological immortality CGK733 fraud Death DNA repair Indefinite lifespan Life extension List of longest-living organisms Maximum life span Regeneration (biology) Rejuvenation (aging) Strategies for engineered negligible senescence